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OPHTHALMIC ULTRASOUND

      Dr. Yousaf Jamal
         26/05/2012
Contents
   • Introduction
   • Instrumentation
   • Indications
   • Ultrasound Principles & physics
   • B-scan, UBM, A-scan & techniques
   • MCQs



3/15/2013                               2
Objectives
   • To create awareness about basics of US
   • To emphasize on the importance of
     ophthalmic US
   • To create & follow standard operating
     protocol while performing ophthalmic US




3/15/2013                                      3
Introduction
   • Sound…
   • Noise…
   • Ultrasound…
   • What is…
            − Supersonic
            − Hypersonic
            − Transonic



3/15/2013                           4
• Just for test of general knowledge
   • Who was the first one to use ultrasound?




                      ?
3/15/2013                                       5
Echolocation types




3/15/2013                        6
TYPES


    A – SCAN

    B – SCAN
Instrumentation
   • Pulsed-echo system
            − Transducer
            − Amplifier
            − Display monitor




3/15/2013                            8
Transducer function
               ELECTRIC CURRENT


                  TRANDUCER


                  US WAVES


                   SURFACE

3/15/2013                         9
Artist: Dr. Yousaf Jamal




3/15/2013                              10
B-Scan




3/15/2013            11
B-scan
   • Brightness mode scan
   • OPD procedure




3/15/2013                   12
Indications
   • To examine intraocular structures with no
     direct visualization of posterior segment
                       Or
   • To confirm or differentiate between
     pathologies in clear media




3/15/2013                                        13
Ultrasound physics & principles
   • Parts of Sound wave
            − Amplitude
            − Wavelength (crest & trough)
            − Frequency




3/15/2013                                   14
Frequency & its relations


            With resolution
               Image quality


            With penetration
              How much deep




3/15/2013                         15
Frequency versus Resolution




3/15/2013                         16
3/15/2013   17
Frequency versus Penetration




3/15/2013                         18
3/15/2013   19
Medical Ultrasound frequencies
   • Abdominal US
            − 1-5 MHz
   • Ophthalmic US (B-scan)
            − 8-10 MHz
   • Ultrasound Biomicroscopy (UBM)
            − 20-50 MHz




3/15/2013                             20
Ophthalmic US
   • B-scan
            − 10 MHz
            − 40 mm
            − 940 microns
   • UBM
            − 50 MHz
            − 5-10 mm
            − 40 microns



3/15/2013                          21
Principles of US
   • Velocity
   • Reflectivity
   • Angle of incidence
   • Absorption




3/15/2013                       22
Velocity
• Depends upon density of medium
• Distance = speed x time
  − Thru air                − Thru aqueous & vitreous
     • 330 m/s                 • 1532 m/s
  − Thru water              − Thru cornea & lens
     • 1500 m/s                • 1641 m/s
  − Thru metal              − Thru silicon oil…1000 CS
     • 5000 m/s                • 980 m/s
  − Thru blood              − Thru silicon oil…5000 CS
     • 1570 m/s                • 1040 m/s


     3/15/2013                                           23
Reflectivity (Echo)
   • Follows law of Acoustic impedance
   • A.I. = sound velocity x density of medium
  Medium         Acoustic impedance (x106) kgm-2 s-1
  Fat            1.38
  Human tissue   1.63
  Blood          1.61
  Muscle         1.70
  Bone           5.6-7.8
  Vitreous       1.52
  Aqueous        1.50
  Lens           1.84                                  24
3/15/2013
• Higher gain for weaker echoes
   • Low gain for stronger echoes




3/15/2013                            25
Angle of incidence


             Transducer




3/15/2013                        26
Absorption
   • Dependent on density of medium
   • Closed lids should be therefore avoided
     but in children or open wound
   • Shadowing occurs bcz of it




3/15/2013                                      27
Probe positioning

   • Trans-ocular approach
            − Transverse
            − Longitudinal
            − Axial
   • Para-ocular approach




3/15/2013                             28
Trans-ocular
                       Transverse position

            −   Most commonly used position
            −   Shows about 6 clock hours
            −   Used for basic screening
            −   Detects lateral extent of pathology
            −   Probe is placed opposite to the examined
                meridian



3/15/2013                                                  29
− Probe marker is tangential to limbus
            − Mark is at nasal side when scanning 6 and
              12 o’clock
            − For the rest…marker is superior
            − Limbus-to-fornix approach is used to
              detect from posterior pole to periphery




                                            Nasal
3/15/2013                                   Bridge        30
Longitudinal positions

            − Detects axial (AP) extent of pathology
            − Useful for retinal tears detection
            − Shows only 1 clock hour scan




3/15/2013                                              31
− Probe mark is perpendicular to limbus
            − Pt looks towards the area of interest
            − Optic nerve shadow is always at bottom of
              scan
            − Limbus-to-fornix approach can be used




3/15/2013                                                 32
Axial positions
   • Probe direct over the cornea
   • Pt looks in primary gaze
   • US waves pass thru center of lens and hit
     optic nerve rather than macula
   • Lens density affects the quality of image




3/15/2013                                        33
Positions of axial scan
   • Horizontal
            − Marker always nasal
   • Vertical
            − Marker always superior
   • Oblique
            − Marker always superior
                                             Nasal
                                             Bridge


3/15/2013                                             34
Basic screening technique
   • Done for screening purpose in opaque
     media
   • Highest gain settings are used so weaker
     signals shouldn’t be missed
   • Any pathology found…further scanning is
     required




3/15/2013                                       35
Technique
   • 05 scans in different positions will detect
     gross pathology
   • Transverse position with limbus-to-fornix
     approach in…
            − 12, 3, 6 and 9 o'clock
   • Horizontal axial scan…shows optic nerve
     & macula in one image
   • Print out of each position is taken with
     labels
3/15/2013                                          36
If pathology found…
   • Clock hour noted on transverse scan
   • Patient is asked to look in the direction of
     pathology
   • Probe should be perpendicular
   • Longitudinal scan, A-scan & change of
     gains…adds further info of pathology




3/15/2013                                           37
Localization of macula
   • 04 positions for macular detection
            −   Horizontal axial
            −   Vertical axial
            −   Transverse…probe placed nasally
            −   Longitudinal…probe placed nasally




3/15/2013                                           38
Anterior segment evaluation


              Immersion technique




            High resolution technique



3/15/2013                               39
Immersion technique
   • Cornea, anterior chamber & lens create
     noise bcz of close contact with probe
   • Shell or water bath is used to create
     space




3/15/2013                                     40
High resolution technique
   • Ultrasound biomicroscopy
   • High resolution probes are used
   • Scleral shell technique is used
   • Image quality far superior to immersion
     technique




3/15/2013                                      41
3/15/2013   42
Common examples
                     Vitreoretinal disorders
   • Most common indication for B-scan
            −   Vitreous hemorrhage
            −   Retinal detachment
            −   Intraocular tumors
            −   Intraocular foreign bodies




3/15/2013                                      43
Vitreous hemorrhage
   • Fresh:
            − Dot-like…Echolucent or low reflectivity
   • Old:
            − Membrane-like…varying reflectivity &
              dense inferiorly




3/15/2013                                               44
Fresh VH   Old VH
3/15/2013                       45
3/15/2013   46
Retinal detachment
   • Rhegmatogenous R/D:

            − Thin, continuous membrane anteriorly
              separated from globe wall
            − Echoes are of high amplitue-100% of
              scleral spike
            − Retinal cysts, subretinal hemorrhages may
              be seen




3/15/2013                                                 47
3/15/2013   48
• Tractional R/D:

            − Traction membranes are seen
            − R/D usually doesn’t extend to ora serrata
            − Lower mobility in contrast to Rheg. R/D




3/15/2013                                                 49
3/15/2013   50
3/15/2013   51
• Exudative R/D:

            − Smooth elevation of retina
            − Shifting fluid




3/15/2013                                  52
Supine position




     Erect position

3/15/2013                               53
Intraocular tumors
   • Retinoblastoma:

            − Single or multiple mass lesions arising
              from retina
            − Highly refractile calcium seeding in
              vitreous +/- orbital shadowing
            − R/D may be found




3/15/2013                                               54
3/15/2013   55
• Choroidal melanoma:

            − Solid Dome shaped or mushroom shape
            − High surface reflectivity with low to
              medium internal reflectivity
            − A scan flickering spikes…internal blood
              flow
            − Choroidal excavation
            − Exudative R/D may be present


3/15/2013                                               56
3/15/2013   Dome shape   57
Collar stud shape
     Arrowhead in A scan shows bruch’s membrane
3/15/2013                                         58
Intraocular foreign body
   • Echodense signals with shadowing
   • Persistence of signals at low gains
   • Glass…reverberations
   • Air bubble…may simulate IOFB




3/15/2013                                  59
3/15/2013   60
Dislocated lens
   • Signals depend on clarity of lens
   • Clear lens…Echolucent globular structure
   • Brunescent lens…highly reflective with
     shadowing




3/15/2013                                       61
3/15/2013   62
3/15/2013   63
A-Scan



3/15/2013            64
A - scan
   • Amplitude scan
   • 10 MHz probe
   • Measures axial length of eye and used for
     diagnostic purposes when combined with
     B-scan
   • Follows law of acoustic impedance




3/15/2013                                        65
• X-axis…time
   • Y-axis…amplitude
   • Method
            − Applanation technique
            − Immersion technique




3/15/2013                             66
A-scan by Applanation
• Cornea is anesthetized
• Patients should look directly at the red
  fixation light
• Probe placed directly on cornea
• This causes a slight indentation (0.14 -
  0.28 mm)
• Measurements vary slightly from each
     other due to inconsistent corneal
     compression
   • Also, will have a shallower AC depth than
     immersion
   • Takes (20) readings




3/15/2013                                        68
• At least (4) of these should be within 0.02
  mm of each other, and should look like
  the previous slide
• This way the measurements will be made
  to the center of the macula, giving the
  refractive axial length, rather than
  anatomical axial length
3/15/2013   70
3/15/2013   71
3/15/2013   72
A- Scan facts
• Average length of the eye: 23.5mm
• Average A/C depth: 3.24mm (but can
  vary greatly)
• Average lens thickness: 4.63mm ( but can
  vary with cataractous changes up to as
  thick as 7.0mm in density)
• Average K’s : 43.00 – 44.00D
Summary
   • Ophthalmic US…high frequency
   • A & B scans mostly used
   • Different pathologies can be diagnosed
     easily when both scans are used
     simultaneously




3/15/2013                                     74
Take home message
   • Understanding of basic physics
   • Proper standardized technique should be
     applied in each case
   • ‘Eyes do not see what mind does not
     know’
   • So background knowledge of pathologies
     and experience count the yield of US



3/15/2013                                      75
3/15/2013   76
MCQs / Cases



3/15/2013       77
MCQs / Cases
   1. A patient presents with bilateral granulomatous
   panuveitis with hazy fundus view due to cataract. No
   Hx of trauma. B scan picture is given below:




3/15/2013                                                 78
A. What is the probe position?
   • Axial
   B. What do the arrow head and arrow show?
   • Retinal detachment
   • Choroidal thickening
   C. Probable diagnosis?
   • V-K-H




3/15/2013                                      79
2. A young patient with blunt ocular trauma comes to
   your opd, complaining of floaters with normal visual
   acuity. You order B scan which is given below




3/15/2013                                                 80
• Describe the picture
   • What is your probable diagnosis?
   • How you differentiate it from retinal detachment?




3/15/2013                                                81
3. An old patient complains of decreased vision after
   trabeculectomy. There is large bleb but hypotonic
   eye. B scan shows




3/15/2013                                                  82
• Describe the picture
   • Your probable diagnosis?




3/15/2013                       83
4. Describe the following A-scan




   Ans… Immersion technique A-scan
3/15/2013                             84
5. What you say about these A-scans?




   Ans… Artifacts By IOL (Reverberations)


3/15/2013                                   85
6. Diagnosis?




Ans…Hypotonic eye with choroidal thickening
   3/15/2013                                  86
NEXT
   • Lecture
   • Dr. Bilal… corneal topography


   • Journal club
   • Dr. Maooz




3/15/2013                            87

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Ophthalmic ultrasound

  • 1. OPHTHALMIC ULTRASOUND Dr. Yousaf Jamal 26/05/2012
  • 2. Contents • Introduction • Instrumentation • Indications • Ultrasound Principles & physics • B-scan, UBM, A-scan & techniques • MCQs 3/15/2013 2
  • 3. Objectives • To create awareness about basics of US • To emphasize on the importance of ophthalmic US • To create & follow standard operating protocol while performing ophthalmic US 3/15/2013 3
  • 4. Introduction • Sound… • Noise… • Ultrasound… • What is… − Supersonic − Hypersonic − Transonic 3/15/2013 4
  • 5. • Just for test of general knowledge • Who was the first one to use ultrasound? ? 3/15/2013 5
  • 7. TYPES A – SCAN B – SCAN
  • 8. Instrumentation • Pulsed-echo system − Transducer − Amplifier − Display monitor 3/15/2013 8
  • 9. Transducer function ELECTRIC CURRENT TRANDUCER US WAVES SURFACE 3/15/2013 9
  • 10. Artist: Dr. Yousaf Jamal 3/15/2013 10
  • 12. B-scan • Brightness mode scan • OPD procedure 3/15/2013 12
  • 13. Indications • To examine intraocular structures with no direct visualization of posterior segment Or • To confirm or differentiate between pathologies in clear media 3/15/2013 13
  • 14. Ultrasound physics & principles • Parts of Sound wave − Amplitude − Wavelength (crest & trough) − Frequency 3/15/2013 14
  • 15. Frequency & its relations With resolution Image quality With penetration How much deep 3/15/2013 15
  • 17. 3/15/2013 17
  • 19. 3/15/2013 19
  • 20. Medical Ultrasound frequencies • Abdominal US − 1-5 MHz • Ophthalmic US (B-scan) − 8-10 MHz • Ultrasound Biomicroscopy (UBM) − 20-50 MHz 3/15/2013 20
  • 21. Ophthalmic US • B-scan − 10 MHz − 40 mm − 940 microns • UBM − 50 MHz − 5-10 mm − 40 microns 3/15/2013 21
  • 22. Principles of US • Velocity • Reflectivity • Angle of incidence • Absorption 3/15/2013 22
  • 23. Velocity • Depends upon density of medium • Distance = speed x time − Thru air − Thru aqueous & vitreous • 330 m/s • 1532 m/s − Thru water − Thru cornea & lens • 1500 m/s • 1641 m/s − Thru metal − Thru silicon oil…1000 CS • 5000 m/s • 980 m/s − Thru blood − Thru silicon oil…5000 CS • 1570 m/s • 1040 m/s 3/15/2013 23
  • 24. Reflectivity (Echo) • Follows law of Acoustic impedance • A.I. = sound velocity x density of medium Medium Acoustic impedance (x106) kgm-2 s-1 Fat 1.38 Human tissue 1.63 Blood 1.61 Muscle 1.70 Bone 5.6-7.8 Vitreous 1.52 Aqueous 1.50 Lens 1.84 24 3/15/2013
  • 25. • Higher gain for weaker echoes • Low gain for stronger echoes 3/15/2013 25
  • 26. Angle of incidence Transducer 3/15/2013 26
  • 27. Absorption • Dependent on density of medium • Closed lids should be therefore avoided but in children or open wound • Shadowing occurs bcz of it 3/15/2013 27
  • 28. Probe positioning • Trans-ocular approach − Transverse − Longitudinal − Axial • Para-ocular approach 3/15/2013 28
  • 29. Trans-ocular Transverse position − Most commonly used position − Shows about 6 clock hours − Used for basic screening − Detects lateral extent of pathology − Probe is placed opposite to the examined meridian 3/15/2013 29
  • 30. − Probe marker is tangential to limbus − Mark is at nasal side when scanning 6 and 12 o’clock − For the rest…marker is superior − Limbus-to-fornix approach is used to detect from posterior pole to periphery Nasal 3/15/2013 Bridge 30
  • 31. Longitudinal positions − Detects axial (AP) extent of pathology − Useful for retinal tears detection − Shows only 1 clock hour scan 3/15/2013 31
  • 32. − Probe mark is perpendicular to limbus − Pt looks towards the area of interest − Optic nerve shadow is always at bottom of scan − Limbus-to-fornix approach can be used 3/15/2013 32
  • 33. Axial positions • Probe direct over the cornea • Pt looks in primary gaze • US waves pass thru center of lens and hit optic nerve rather than macula • Lens density affects the quality of image 3/15/2013 33
  • 34. Positions of axial scan • Horizontal − Marker always nasal • Vertical − Marker always superior • Oblique − Marker always superior Nasal Bridge 3/15/2013 34
  • 35. Basic screening technique • Done for screening purpose in opaque media • Highest gain settings are used so weaker signals shouldn’t be missed • Any pathology found…further scanning is required 3/15/2013 35
  • 36. Technique • 05 scans in different positions will detect gross pathology • Transverse position with limbus-to-fornix approach in… − 12, 3, 6 and 9 o'clock • Horizontal axial scan…shows optic nerve & macula in one image • Print out of each position is taken with labels 3/15/2013 36
  • 37. If pathology found… • Clock hour noted on transverse scan • Patient is asked to look in the direction of pathology • Probe should be perpendicular • Longitudinal scan, A-scan & change of gains…adds further info of pathology 3/15/2013 37
  • 38. Localization of macula • 04 positions for macular detection − Horizontal axial − Vertical axial − Transverse…probe placed nasally − Longitudinal…probe placed nasally 3/15/2013 38
  • 39. Anterior segment evaluation Immersion technique High resolution technique 3/15/2013 39
  • 40. Immersion technique • Cornea, anterior chamber & lens create noise bcz of close contact with probe • Shell or water bath is used to create space 3/15/2013 40
  • 41. High resolution technique • Ultrasound biomicroscopy • High resolution probes are used • Scleral shell technique is used • Image quality far superior to immersion technique 3/15/2013 41
  • 42. 3/15/2013 42
  • 43. Common examples Vitreoretinal disorders • Most common indication for B-scan − Vitreous hemorrhage − Retinal detachment − Intraocular tumors − Intraocular foreign bodies 3/15/2013 43
  • 44. Vitreous hemorrhage • Fresh: − Dot-like…Echolucent or low reflectivity • Old: − Membrane-like…varying reflectivity & dense inferiorly 3/15/2013 44
  • 45. Fresh VH Old VH 3/15/2013 45
  • 46. 3/15/2013 46
  • 47. Retinal detachment • Rhegmatogenous R/D: − Thin, continuous membrane anteriorly separated from globe wall − Echoes are of high amplitue-100% of scleral spike − Retinal cysts, subretinal hemorrhages may be seen 3/15/2013 47
  • 48. 3/15/2013 48
  • 49. • Tractional R/D: − Traction membranes are seen − R/D usually doesn’t extend to ora serrata − Lower mobility in contrast to Rheg. R/D 3/15/2013 49
  • 50. 3/15/2013 50
  • 51. 3/15/2013 51
  • 52. • Exudative R/D: − Smooth elevation of retina − Shifting fluid 3/15/2013 52
  • 53. Supine position Erect position 3/15/2013 53
  • 54. Intraocular tumors • Retinoblastoma: − Single or multiple mass lesions arising from retina − Highly refractile calcium seeding in vitreous +/- orbital shadowing − R/D may be found 3/15/2013 54
  • 55. 3/15/2013 55
  • 56. • Choroidal melanoma: − Solid Dome shaped or mushroom shape − High surface reflectivity with low to medium internal reflectivity − A scan flickering spikes…internal blood flow − Choroidal excavation − Exudative R/D may be present 3/15/2013 56
  • 57. 3/15/2013 Dome shape 57
  • 58. Collar stud shape Arrowhead in A scan shows bruch’s membrane 3/15/2013 58
  • 59. Intraocular foreign body • Echodense signals with shadowing • Persistence of signals at low gains • Glass…reverberations • Air bubble…may simulate IOFB 3/15/2013 59
  • 60. 3/15/2013 60
  • 61. Dislocated lens • Signals depend on clarity of lens • Clear lens…Echolucent globular structure • Brunescent lens…highly reflective with shadowing 3/15/2013 61
  • 62. 3/15/2013 62
  • 63. 3/15/2013 63
  • 65. A - scan • Amplitude scan • 10 MHz probe • Measures axial length of eye and used for diagnostic purposes when combined with B-scan • Follows law of acoustic impedance 3/15/2013 65
  • 66. • X-axis…time • Y-axis…amplitude • Method − Applanation technique − Immersion technique 3/15/2013 66
  • 67. A-scan by Applanation • Cornea is anesthetized • Patients should look directly at the red fixation light • Probe placed directly on cornea • This causes a slight indentation (0.14 - 0.28 mm)
  • 68. • Measurements vary slightly from each other due to inconsistent corneal compression • Also, will have a shallower AC depth than immersion • Takes (20) readings 3/15/2013 68
  • 69. • At least (4) of these should be within 0.02 mm of each other, and should look like the previous slide • This way the measurements will be made to the center of the macula, giving the refractive axial length, rather than anatomical axial length
  • 70. 3/15/2013 70
  • 71. 3/15/2013 71
  • 72. 3/15/2013 72
  • 73. A- Scan facts • Average length of the eye: 23.5mm • Average A/C depth: 3.24mm (but can vary greatly) • Average lens thickness: 4.63mm ( but can vary with cataractous changes up to as thick as 7.0mm in density) • Average K’s : 43.00 – 44.00D
  • 74. Summary • Ophthalmic US…high frequency • A & B scans mostly used • Different pathologies can be diagnosed easily when both scans are used simultaneously 3/15/2013 74
  • 75. Take home message • Understanding of basic physics • Proper standardized technique should be applied in each case • ‘Eyes do not see what mind does not know’ • So background knowledge of pathologies and experience count the yield of US 3/15/2013 75
  • 76. 3/15/2013 76
  • 78. MCQs / Cases 1. A patient presents with bilateral granulomatous panuveitis with hazy fundus view due to cataract. No Hx of trauma. B scan picture is given below: 3/15/2013 78
  • 79. A. What is the probe position? • Axial B. What do the arrow head and arrow show? • Retinal detachment • Choroidal thickening C. Probable diagnosis? • V-K-H 3/15/2013 79
  • 80. 2. A young patient with blunt ocular trauma comes to your opd, complaining of floaters with normal visual acuity. You order B scan which is given below 3/15/2013 80
  • 81. • Describe the picture • What is your probable diagnosis? • How you differentiate it from retinal detachment? 3/15/2013 81
  • 82. 3. An old patient complains of decreased vision after trabeculectomy. There is large bleb but hypotonic eye. B scan shows 3/15/2013 82
  • 83. • Describe the picture • Your probable diagnosis? 3/15/2013 83
  • 84. 4. Describe the following A-scan Ans… Immersion technique A-scan 3/15/2013 84
  • 85. 5. What you say about these A-scans? Ans… Artifacts By IOL (Reverberations) 3/15/2013 85
  • 86. 6. Diagnosis? Ans…Hypotonic eye with choroidal thickening 3/15/2013 86
  • 87. NEXT • Lecture • Dr. Bilal… corneal topography • Journal club • Dr. Maooz 3/15/2013 87