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BASICS OF CT & MRI
COMPUTED
TOMOGRAPHY
   INTRODUCTION
   OVER the last 40 years an array of imaging modalities
    has been developed that has enhanced the already
    versatile x-ray generating equipment and film used in
    conventional image production.
    computed tomography was developed in the early to
    mid 1970s and is a radiographic technique for producing
    cross-sectional tomographic images.
   Claimed to be 100 times more sensitive than
    conventional x-ray systems, it demonstrated differences
    between various soft tissues never before seen with x-
    ray imaging techniques.
HISTORY
   1961-Oldendorff W.H recognized the potential of
    reconstruction tomography.
   1963- Cornmark used a source and detector rotate
    around a non symmetrical phantom and a computed for
    processing the transmission data.
   1972- Godfrey Hounsfield an engineer at EMI(Electrical
    musical instruments) limited, England announced the
    invention of a revolutionary imaging technique which he
    referred to as Computerized Axial Transverse Scanning..
 With this technique he was able to produce an axial
  cross-sectional image of the head using a narrowly
  collimated ,moving beam of X-rays.
 1979-Cornmack and Hounsfield were awarded the
  Noble prize in Physiology and Medicine.
 From 1971to 1975 ,within a span of 4 years, four
  generation of scanner evolved, which yielded shorter
  times and better control over the patient‟s motion.
 In fifth generation CT scanner, scanning time is reduced
  to 16 milliseconds.
   1998- CBCT was invented

 Synonyms;
 Computerized Axial Tomography
   Computerized Reconstruction
   Computerized Tomographic Scanning
 Axial Tomography
   Computerized transaxial Tomography
   TOMOGRAPHY



   Tomography is a process by which an image layer
    of the body is produced, while the images of the
    structures above and below that layer are made
    invisible by blurring.
Tomography may be classified into many types:
 Conventional Tomography
 Computed Tomography
 Three - dimensional C T
 Spiral Computed Tomography
 Emission Computed Tomography
Conventional Tomography
 Tomography is a generic term, formed from the
  Greek words tomo (slice) and graph (picture)
  that was adopted in 1962 by the International
  Commission on Radiographic Units and
  Measurements to describe all forms of body
  section radiography.
   This is achieved by a synchronized movement of the
    film and the tube in opposite directions, about a
    fulcrum (i.e. the plane of interest in the patient's
    body). Objects closest to the film are seen most
    sharply and objects farthest away are completely
    blurred.
   The thickness of the image layer depends on the
    angle of rotation or the amount of movement of the
    tube.
   Some degree of image degradation also occurs
    within the image layer. The greatest amount of
    blurring is at the periphery of the image layer, and
    the sharpest image is at the center
Computed Tomography (CT)
 A computed tomographic image is a
  display of anatomy of a thin slice of body
  developed from multiple X-ray absorption
  measurements made around the body's
  periphery.
 Computed tomography (CT) permits the
  imaging of thin slices of tissue in a wide
  variety of planes.
 Most CT is done in the axial plane, and
  many CT scans also provide coronal
  views; sagittal slices are less commonly
  used.
Slice thickness is usually
10 mm through the body and brain

 5 mm through the head and neck, unless
three dimensional reconstruction is
anticipated.

 In such cases, the slice thickness is 1.0 to
1.5 mm in order to provide adequate data
BASIC PRINCIPLE
   CT scanners use the X-rays to produce the sectional
    or slice images ,as in conventional tomography, but
    radiographic film is replaced by sensitive detectors.
    The detectors measure the intensity of the x-ray
    beam emerging from the patient and convert this
    into digital data which are stored and can be
    manipulated by a computer. This numerical
    information is converted into a gray scale
    representing different tissue densities ,thus
    allowing a visual image to be generated.
CT Scanner Generations
   1. First generation (Rotate / Translate, pencil beam)
   The original EMI unit was the first generation scanner. It was
    rotate/translate pencil beam system. Only two detectors were
    used, which measured transmission of X-ray through the
    patient for two different slices. That is two tomographic
    sections were taken simultaneously. It was designed
    specifically for evaluation of brain. In this unit head was
    enclosed in a water bath.
   The linear motion was repeated 180 times and after one linear
    movement ,gantry rotated 1 degree.
   X-ray beam was on during linear motion ,while off during
    rotation.
   The transmitted radiation was 160 times during each linear
    movement .
   Total no. of transmission-160x180= 28,800

 Scan time was 4.5 to 5 min.
 Matrix was 80x80
 Second generation (Rotate / Translate, narrow
  fan beam)
 Second generation scanner were also of translate-
  rotate type. These units were incorporated a linear
  array of 30 detectors. The use of 30 detectors
  increased the utilization of the X-ray beam by 30
  times over the single detector used per slice in
  first generation systems. Source detector assembly
  intercepting a fan shaped (a narrow fan angle of
  10°) beam rather than a pencil sized X-rays beam.
 Instead of moving 1 degree at the end of each
  linear scan ,the gantry rotates through a greater
  arc, upto 30 degree. So linear movement have to
  be repeated six times to cover 180 degree.
 Scan time was 10-90 sec.
 Third generation (Rotate/rotate wide fan
  beam)
 The translation motion of first and second
  generation was a major limitation because at the
  end of each translation, the translational inertia of
  X-ray tube/detector system had to be stopped; the
  whole system rotated and then the translation
  motion had to be restarted. This design could
  never have led to fast scanning.
 To overcome this limitation third generation
  scanners evolved. Third generation scanner uses
  increased number of detector (upto about 750
  detector) and rotate-rotate system i.e. X-ray tube
  and detector array were rotated. The detector is
  aligned around an area of a circle whose centre is
  focal spot. X-ray beam is collimated into fan
  beam (fan angle was about 50°).
 Scan time was 2 to 10 sec.
3rd generation configuration
 Cone Beam Radiology
 CBCT uses a round or rectangular cone –
  shaped x-ray beam centered on a two –
  dimensional x-ray sensor to scan a 360
  degree rotation about the patient‟s head.
  During the scan a series of 360 exposures
  or projections, one for each degree of
  rotation, is acquired, which provide raw
  digital data for reconstruction of the
  exposed volume by computer algorithm.
   Depending on the equipment, scan time
    range from 17 sec to little more than 1 min.
   Multiplanar reformatting of the primary
    reconstruction allows for both three-
    dimensional and two-dimensional images of
    any selected plane to be made.
   Resolving power is four times that of CT
   Less expensive
   Radiation dose is 3-20 % that of
    conventional CT.
   Fourth generation CT scanner (rotate
    /stationary)
   Fourth generation CT scanner were designed to
    overcome the problem of electronic drift between
    many detectors used in the system so this design
    eliminated ring artifact.
   Fourth generation CT scanner uses rotate only
    motion. Huge tube rotated but the detector
    assembly does not. The detector forms a ring that
    completely surrounds the patient. The X-ray tube
    rotates in a circle inside the detector ring and X-
    ray beam was collimated to form a fan beam.
   Was not faster in principle than third generation.
   Easier detector calibration.
 4th
    generation
  configuration
 Fifth generation systems-
 Developed by Dr. E Woods of Mayo
  Clinic. System consists of multiple rays
  tubes and detectors. Such a unit is
  primarily used to image 3D sections of the
  heart and reduces artifacts caused due to
  cardiac rhythm.
CT EQUIPMENT
  The equipment consist of:
 Gantry containing x-ray source, detectors
  and electronic measuring devices
 Motorized table- used to position the patient
  within gantry
 X-ray power supplies and controls
 Computer
 Viewing devices
X-RAY TUBES
 Radiation source for CT would supply
  monochromatic X-ray beam by which
  image reconstruction is simple and more
  accurate.
 Earlier models used oil-cooled, fixed –
  anode, relatively large (2x16mm)focal
  spot tubes at energies of about 120
  kilovolt (constant potential) and 30mA.
  The beam was heavily filtered to move
  low energy photons and to increase the
  mean energy of the radiation.
   Most newer fan beam units have a
    diagnostic –type x-ray tube with a rotating
    anode and a much smaller focal spot ,in
    some units down to 0.6mm and generate
    X-rays in short bursts, or pulses. These
    tubes are air-cooled and operate at much
    higher currents, upto 600mA. They are
    (cathode-anode ) perpendicular to the fan
    beam to avoid asymmetry in X-ray output
    because of the heel effect.
   Recently, special types of X-ray tubes
    have been developed for CT. These tubes
    are designed to withstand the very high
    heat loads generated when multiple slices
    are acquired in rapid sequence.
COLLIMATORS
 The x-ray beam is collimated at two
  points ,one close to the x-ray tube and the
  other at the detector.
 The collimator at the detector is the sole
  means of controlling scatter radiation.
 The collimators also regulate the thickness
  of the tomographic section(voxel length)
Detectors-
1.Gas filled ion chamber detectors made of
  high pressure xenon.
           Capture about 50 % photons in
  the beam
2. Solid state detector
           commonly used, 80% efficient.
         Usually made of cadmium
    tungstate.

            TECHNIQUE image
    The process by which production of CT
    occur is called scanning.

   The patient lies down with the part of the body to
    be examined within the circular gantry, housing the
    X-ray tube head and detector.

   The level of plane and thickness of the section to
    be imaged are selected and x-ray tube head
    rotates around the patient, scanning that section.
   As the tube head rotate around the patient each
    set of detector produces an attenuation or
    penetration profile of the region of the body being
    examined.
   These detectors produce electrical impulses that are
    pro-portional to the intensity of the X-ray beam emerging
    from the body

   That intensity is determined by various factors;
      1. the energy of the X-ray source,
      2. the distance between the source and the detector
      3.the attenuation of the beam by the material in the
    object being scanned.

   Penetration profile is stored in the computer, which
    calculates the density or absorption at points on a grid
    formed by the intersections of penetrating profiles.

   The CT image is a digital image, reconstructed by the
    computer, which mathematically manipulates the
    transmission data obtained from the multiple projections
   The image consists of a matrix of individual blocks
    called voxels (volume element).It consist of an
    array of individual points or pixels.


   The size of the pixel is determined by:
   The geometry of the scan,
   The frequency and spacing of measurements,
   The number of penetration profiles and
   The size of the x-ray source and detector

 Each    pixel is assigned a CT number or Hounsfield
    unit(HU) between +1000 to -1000, depending upon
    the amount of the absorption within that block of
    tissue.
 Each number or pixel represents a
 calculation of the actual attenuation of
 the X-ray beam by materials with the
 body. It represents the absorption
 characteristics or linear attenuation
 coefficient of that particular volume of
 tissue in the patient.
 IMAGE RECONSTRUCTION
 Images are typically 512 x 512 or 1024 x
  1024 pixels.
 Rapid image reconstruction done by
      Two-dimensional Fourier Analysis
       Filtered back projection
   CT numbers for various body tissues.

        Absorber       CT number/HU
        Bone (dense)   +400 to +1000
        Soft tissues   +40 to +80


        Water          0
        Fat            -60 to -100
        Lung           -400 to -600
        Air            -1000
 The computer can construct an image by
 printing the numbers or assigning different
 degree of greyness to each CT number. In some
 system ,the numerical values are translated into
 colours or brightness level that can be displayed
 on a television screen or printed on a paper.
Image display-----In two basic mode
 As a paper printout of CT numbers
 As a gray scale image on a cathode ray
  tube or television monitor.
 WINDOW LEVEL AND WINDOW
  WIDTH
 These two variables enable the visual image
  to be altered by selecting the range and level
  of densities to be displayed.
 Window level-is the CT numbers selected for
  the centre of the range depending on weather
  the lesion under investigation is in the soft
  tissue or bone.
 Window width-is the range of CT numbers
  selected for various shades of grey.
 The contrast and brightness of the image
  may be adjusted as necessary although the
  images are usually viewed in two modes:
 Bone windowing and soft-tissue windowing.
 In Bone windowing, the contrast is set so
  that osseous structures are visible in maximal
  detail.
 With soft-tissue windowing, the bone
   looks uniformly white, but various types of
  soft tissues can be distinguished.
DISTORTION
A signal can contain errors or distortions that are
repeatable (deterministic). For instance, if a patient
moves during the acquisition step, parts of the
anatomy may be blurred or in different positions
from their true location. If the image reconstruction
process requires linear and consistent data, but the
measurements for some reason are not consistent,
artifacts can arise that may result in lost information
or spurious image features.
ARTIFACT
   Any discrepancy between the CT
    numbers represented in the image
    and the expected CT number based
    on the linear attenuation coefficient
 IMAGE ARTIFACTS
1. Partial volume artifact
2. Beam hardening artifact
   (due to absorption of low energy
   photon from the beam.)
3. Metal artifacts
METAL ARTIFACT
 MANIFEST AS “STAR STREAKING”
  ARTIFACT.
 CAUSED BY PRESENCE OF
  METALLIC OBJECTS INSIDE OR
  OUTSIDE THE PATIENT.
 METALLIC OBJECT ABSORBS THE
  PHOTONS CAUSING AN
  INCOMPLETE PROFILE
METAL ARTIFACT
   CONTRAST MEDIA
   Is used to obtain a differential change in the
    attenuation values of normal and pathologic tissues
    so that recognition of pathology is facilitated. one
    can expect a large variety of contrast enhancement
    in pathological tissues due to tissue alterations,
    mainly related to differences in vascular contrast
    distribution volume and total distribution volume.
   Iodine based
     iodine monomers-
                   iothalmate, diatrizoate, metrizoate
   Non ionic monomer like iopamidol ,iotrioxol
   INDICATIONS
   Intracranial diseases and trauma
   Malignancy of jaws
   Infection
   Post-irradiation
   Salivary gland
   Temporomandibular joint
   Implants
   Fracture
   Foreign body
   Imaging of unerupted and displaced teeth,
    bone grafting.
Advantages
 Cross-sectional imaging
 Superior contrast and resolution
 Geometric accuracy
 Images can be manipulated
 Axial tomographic sections are obtainable
 Images can be enhanced by the use of i.v
  contrast media, providing additional
  information.
Disadvantages
 Expensive
 Facilities are not widely available
 Very thin contiguous or overlapping slices
  may result in a high dose of radiation.
 Geometric miss
 Metallic objects such as fillings produce
  marked streak artifacts across the CT
  image.
Recent advances in CT
  3 DIMENSIONAL CT-
 in this data obtained from CT scan is reformatted
  into 3D images.
   3D CT requires that each voxel, shaped as
  rectangular parallel piped or rectangular solid be
  dimensionally altered into multiple cuboidal voxels.
  This process, called interpolation creates sets of
  evenly spaced cuboidal voxels (cuberilles) that
  occupy the same volume as the original voxel.
 The CT numbers of the cuberilles represent the
    average of the original voxel CT numbers
    surrounding each of the new voxel.
   Creation of these new cuboidal voxels allows the
    image to be reconstructed in any plane without loss
    of resolution by locating their position in space
    relative to one another.
   Ultrafast CT: I matron (San Francisco) has developed a
    CT scanner capable of acquiring the data upto 10 times
    faster than conventional CT. About 50msec is able to
    freeze cardiac and pulmonary motion, enhancing the
    quality without motion artifact.


   Spiral CT scanners: (discovered in 1989) in this while
    the gantry containing the x-ray tube and detectors
    revolve around the patient, the patient table continuously
    advances through the gantry. This results in the
    acquisition of a continuous spiral of data as the x-ray
    beam moves down the patient.

  Advantage
 Improved multiplanar image reconstruction
 Reduced examination time(12sec vs 5 min)
 Reduced radiation dose(<75%)
Helical CT is now standard.
 In helical CT scanners, pitch refers to the
  amount of patient movement compared
  with the width of image acquired.
         table travel per X-ray tube rotation
 Pitch=           image thickness
Multidetector helical CT (MDCT,
  multislice CT, or multirow CT)
 Introduced in 1998
 Widely used
 With this method ,anywhere from four to
  64 adjacent detector arrays are used in
  conjunction with helical CT.
 Time for full cycle rotation-0.35sec.
 The quality of axial ,reformatted, and
  three dimensional images ,also improved
  with this as compared to single-slice
  machines.
Electron beam CT– recent development
 In this machine an electron gun generates an
  electron beam that is focused
  electrostatically on a fixed tungsten target
  circling halfway around the patient.
 The X-rays that are generated expose the
  detector array circling the other half of the
  patient.
 Because there are no moving parts ,an image
  may be acquired in less than 100
  microseconds.
 This technique is primarily used for cardiac
  imaging to stop heart motion.
   Emission CT- is similar in principle to x-
    ray transmission CT .instead of section
    morphology ,it reflects physiological
    processes that concentrate the
    radionuclide in one or more organs or
    body compartments.
CBCT                    CT
Less radiation dose   More
More time             Less
Images are of lower   Higher
contrast
Slice thickness 0.1   1-2 mm
mm
Less expensive        More
SIGNIFICANCE OF CT IN
MAXILLOFACIAL REGION
 Trauma
 Neoplasms
 Inflammatory processes
 TMJ disorders
Odontogenic infections
 Cellulitis- soft tissue swelling obliterating
  fat planes.
 Abscess- irregular zone of low density
  with a peripheral rim of contrast
  enhancement.
 Acute osteomyelitis- zone of increased
  contrast enhancement.
 Chronic osteomyelitis- destructive pattern
  with peripheral rim of contrast
  enhancement.
Carl W Hardin and RIC Harnsberger (1985)
made use of CT in evaluation of infections and
tumours involving the masticator spaces and
found that CT is helpful in differentiating
inflammation from frank abscesses.

Alan A Schwimmer et al (1988) emphasized the
role of CT in the diagnosis and management of
temporal and infratemporal space abscesses.
Sialadenitis
 CT is non-invasive, painless and less
  time-consuming.
 Non-contrast CT for detecting calculi.
 Contrast CT for abscess/cellulitis
 Salivary calculi seen as high density, non-
  contrast enhancing mass along the course
  of the duct.
Nick Bryan et al performed CT in 27 patients
with salivary gland neoplasm and concluded that
when CT is combined with the clinical
information and laboratory findings, the overall
specificity in identifying the tumour becomes
90%.
ODONTOGENIC CYSTS
 Appear as localized, expansile
  degenerative area having a fluid density
  throughout the lesion.
 Do not show contrast enhancement in
  contrast aided imaging (except
  Aneurysmal Bone Cyst).
John W Frame and Michael JC Wake evaluated
mandibular keratocysts with CT and established
that CT provides better methods of accurately
displaying the margins of the keratocysts, the areas
of bony perforation and any extension into soft
tissues.
ODONTOGENIC TUMOURS
 Appear as an expansile lesion having a
  soft tissue density which show moderate
  enhancement in contrast aided imaging
  (except cemental tumours).
 Foci of cystic degeneration are commonly
  seen.
 Show breach in cortical plates.
 Foci of calcifications are noticed in
  maturing odontogenic tumours.
 Ameloblastomas- bicortical expansion,
  thinning and breach of bony walls, extension
  of tumour into adjacent soft tissue spaces.
 Focal cystic degenerations commonly seen in
  multilocular lesions.
 Plexiform ameloblastomas have high
  contrast enhancement due to high
  vascularity.
 Cystic ameloblastomas show a predominant
  fluid density.
 Malignant ameloblastomas have a grossly
  destructive pattern.
 Focal hyperdense areas suggesting
  calcifications maybe noticeable in Pindborg
  tumour.
Osborn et al (1982) made a study, on imaging of
several mandibular tumours and established their
osseous and soft tissue extensions. CT was found
valuable in excluding the involvement of mandible
by primary osseous and soft tissue lesions of
adjacent areas.
MALIGNANCIES
 Seen as predominantly destructive lesions
  interspersed with focal high contrast
  enhancement areas.
 Invasive lesions show no/minimal expansion.
 Demarcation from surrounding soft tissue is
  difficult without contrast aided imaging.
 Reparative lesions like central giant cell
  granulomas also manifest as destructive,
  contrast enhancing lesions showing minimal
  or no expansile pattern.
Close LG et al (1986) found a critical factor in the
pretreatment evaluation of patients with carcinoma of the
oral cavity or oropharynx, the presence or absence of bony
invasion. CT was more specific than conventional X-ray
films in detecting bone invasion.

Mark A Cohen and Yancu Hertzanu (1988) in their study on
CGCG using CT, conventional tomogram and conventional
radiographs, proved CT to be superior in clearly
demonstrating the soft tissue mass of lesion, its extension
into adjacent structures and bony destruction.
Fibro-osseous lesions
 CT pattern depends on the maturative
  stage of lesion.
 Cemental lesions are distinguished based
  on the continuity of the lesions with the
  roots of the tooth and the periodontal
  ligament space, separating the lesion from
  the bony alveolus.
Ariji Y et al (1994) studied cases of florid cemento-osseous
dysplasia with conventional radiography and CT and
observed thin, low density areas around high density masses
with expansion of buccal and lingual cortical plates. CT was
able to give additional information by identifying the density
of these masses which ranges from 772-1582 HU. These
values were suggestive of cementum or cortical bone.
MAXILLARY LESIONS
   Maxillary lesions share similar pictures in
    contrast to mandibular lesions which
    make this difficult to distinguish them.
Brenna Betti N, Bruno E et al (1993) For early
diagnosis of the maxillary antrum carcinoma,
besides a conventional radiographic test, also of
more specific analysis, as the computed
tomography and radio therapy.

Colin P and Hodson N. Thirty-two patients with
histologically proved malignant disease involving
the paranasal sinuses were studied by CT.
Significantly greater tumor extent was
demonstrated by CT than by conventional methods.
TMJ
 CT helps identify the bony changes in the
  TMJ like destruction of the condylar head,
  wearing of articular elements, traumatic
  lesions within and outside the capsule.
 Advantageous over arthrography as it is a
  painless procedure with superior
  resolution.
conclusion
   CT scan has made a major impact on the
    practice of dentistry, particularly in oral
    and maxillofacial diagnosis, surgery and
    management of a wide variety of oral
    lesions. Advances in computer softwares
    already allow 3 D visualization of
    anatomy and pathology, but further
    improvement in clinical performance is
    expected.
MAGNETIC
RESONANCE IMAGING
   Here, radiant energy is in the form of
    radiofrequency wave rather than X-ray.

   Father of MRI- Felix Bloch
TYPES OF ATOMIC MOTION
           1.   The electron orbits
                the nucleus

           2.   The electron spins
                on its own axis

           3.   ***The nucleus
                spins on its own
                axis***
MRI USES THE HYDROGEN ATOM
•1 electron orbits the nucleus
•The nucleus contains no neutrons but contains 1
proton

   THE HYDROGEN NUCLEUS HAS A NET
         POSITIVE CHARGE

•Hydrogen nucleus is a spinning, positively charged
particle
LAW OF ELECTROMAGNETISM

•A charged particle in motion will create a
magnetic field
•The postitively charged, spinning hydrogen
nucleus generates a magnetic field

            WHY HYDROGEN?

•Very abundant in the human body-H20
•Has a large magnetic moment
MAGNETIC MOMENT
The tendency of an MR active nuclei to align its
  axis of rotation to an applied magnetic field
        MR ACTIVE NUCLEI
                 odd # protons
                       or
                odd # neutrons
                       or
                    BOTH
e.g. Hydrogen1, Carbon13, Nitrogen15, Oxygen17,
      Fluorine19, Sodium23, Phosphorus31
                  STABLE ATOMS
                # protons = # electrons
                        IONS
               # protons    # electrons
When a body is placed into the bore of the scanner, the strong magnetic field will cause the
individual hydrogen nuclei to either:
          A) ALIGN ANTI-PARALLEL TO THE MAIN MAGNETIC FIELD (B0)
                                              OR
             B) ALIGN PARALLEL TO THE MAIN MAGNETIC FIELD (B0)




                                                       Anti-parallel
                                                       high energy
    B0                                                                                       NMV



                                                                                  Parallel
                                                                                  low
                                                                                  energy
NET MAGNETIZATION
VECTOR
   An excess of hydrogen nuclei will line up
    parallel to B0 and create the NMV of the
    patient
N
                        N


S                        S

    size



           direction   The magnetic
                       vector
THE NUCLEI WILL ALSO
PRECESS…
PRECESSION
 Due to the influence
  of B0, the hydrogen
  nucleus “wobbles” or
  precesses (like a
  spinning top as it
  comes to rest)
 The axis of the
  nucleus forms a path
  around B0 known as
  the “precessional
  path”
PRECESSION
 The speed at which hydrogen precesses depends
  on the strength of B0 and is termed the
  “precessional frequency”
 The precessional frequency of hydrogen in a 1.5
  Tesla magnetic field is 63.86 MHz
 The precessional paths of the individual hydrogen
  nucleus‟ is random, or “out of phase”
 The spinning protons wobble or “precess” about
  that axis of the external Bo field at the
  precessional, Larmor or resonance frequency.
 Magnetic resonance imaging frequency


                     ω= Bo
                where is the gyromagnetic ratio
    The resonance frequency ω of a spin is
    proportional to the magnetic field, Bo.
WE NEED THEM TO BE “IN-
PHASE” OR TO RESONATE…
RESONANCE
Occurs when an object is exposed to an oscillating
perturbation that has a frequency close to its own
         natural frequency of oscillation
RADIOFREQUENCY
ENERGY
 Follows the Law of Electromagnetism
  (charged particles in motion will generate
  a magnetic field)
 Magnetic field known in MR as B1
 Applied as a “pulse” during MR
  sequences
 The RF pulse is applied so that B1 is 90
  to B0
DURING RESONANCE…

1) The hydrogen atoms begin to precess “in phase”
                          1)
2)The hydrogen atoms align with the RF‟s magnetic field
(B1) and they flip!!
AS THE NUCLEI PRECESS IN-PHASE IN THE B1
 PLANE, A CHANGING MAGNETIC FIELD IS
               CREATED

IF YOU PLACE A RECEIVER COIL (ANTENNA) IN
   THE PATH OF THE CHANGING MAGNETIC
     FIELD, A CURRENT WILL BE INDUCED

 THIS IS FARADAY’S LAW OF
         INDUCTION
FARADAY’S LAW OF INDUCTION
    A changing magnetic field will induce an
  electrical current in any conducting medium
                   COILS
                      Used to:
•transmit pulses of radiofrequency energy
•receive induced voltage - MR SIGNAL
•increase image quality by tuning in to one body
part at a time
RELAXATION
When the RF pulse is turned “off”, the NMV “relaxes”
            back to B0 (away from B1)



                                NMV
                B0




                          B1
DIFFERENT TYPES OF COILS



 Gradient Coils
 Radiofrequency Coils
 Shim Coils
GRADIENT COILS
   Three types as per cartesian coordinate
    system- for x, y and z axis; „slice selection
    gradient‟, „phase-encoding gradient‟ and
    „frequency-encoding gradient‟.

   Slice location is selected by frequency of
    the RF pulse while the thickness is
    selected by the bandwidth.
RADIOFREQUENCY COILS


   For transmitting and receiving signals at
    the resonant frequency of the protons
    within the patient
Types of RF Coils
 Transmit Receive       Volume Coil
  Coil                   Surface Coil
 Receive Only Coil      Gradient Coil
 Transmit Only Coil
 Multiply Tuned Coil
MR SIGNAL
 Collected by a coil
 Encoded through a series of complex
  techniques and calculations (magic?)
 Stored as data
 Mapped onto an image matrix
TR - REPETITION TIME

Time from the application of one RF pulse to
            another RF pulse

         TE - ECHO TIME

Time from the application of the RF pulse to
  the peak of the signal induced in the coil
T1 WEIGHTING
•A short TR and short TE will result in a T1
weighted image
•Excellent for demonstrating anatomy
          T2 WEIGHTING
•A long TR and long TE will result in a T2
weighted image
•Excellent for demonstrating pathology

   MANY OTHER DIFFERENT TYPES OF
   IMAGES THAT COMBINE ABOVE AND
     INCLUDE OTHER PARAMETERS
 If TR and TE are less
  (100-500/20ms), image
  contrast is due to
  differences in T1
  relaxation time and we
  get T1 weighted image.
 Used to view anatomic
  details because of
  increased contrast.
 T1 images are also called
  FAT IMAGES because
  fat has shortest T1
  relaxation time.
  Therefore high signal
  and bright image.
 If TR and TE are more
  2000 ms/80 ms, we get
  T2 weighted image. It
  is used for
  inflammatory changes,
  tumors, joint effusions
  perforations.
 T2 are WATER
  IMAGES because
  water has longest T2
  relaxation time.
  Therefore produce high
  signal and bright
  image.
SPECIAL MR
TECHNIQUES
MR using Contrast Medium
   Lesions with increased blood permeability
    demonstrate higher signal intensity than
    that of normal tissue on T1-weighted
    images.
CONTRAST AGENTS
 Most commonly used- Gadolinium.
 Administered intravenously to improve
  tissue contrast.
 Shortens the T1 relaxation times of
  enhancing tissues, making them appear
  brighter.
 Could be a cause of nephrogenic systemic
  fibrosis in some patients with renal
  dysfunction.
MR Angiography
 For detection of vessel systems esp.
  carotid arteries and their branches.
 No contrast agents are injected.
 Vessels with flow appear as bright
  homogenous linear structures on MRA.
 Static tissues appear blurred.
 2 widely available MRA methods are-
  time of flight (TOF) and phase-contrast
  (PC) approaches.
MR Sialography
 Requires no cannulation, contrast or
  ionizing radiation!
 Suitable for patients even with acute
  inflammation.
 This technique is more useful for salivary
  gland ducts.
 Virtual endoscopy using MR sialographic
  imaging data enables depiction of inner
  surfaces of parotid and submandibular
  ducts.
MR Cisternography
 No lumbar puncture, contrast medium or
  ionizing radiation!
 Cisterns of the brain are demonstrated as
  high signal intensity structures that
  coincide with the shape of the cistern.
 Invaluable for ruling out brain tumours in
  patients with trigeminal neuralgia.
Functional MRI
 New tool for evaluating specific hypothesis
  concerning the anatomical regions of the
  human brain involved in processing sensory
  and motor information.
 Small signal changes appear hyperintense on
  fMRI; these are related to alterations in blood
  oxygenation levels and therefore changes in
  the magnetization of protons within the blood.
 Enable identification of motor and sensory
  areas of brain related to oral functions eg.
  Occlusion.
UNITS OF MAGNETIC FIELD
 TESLA & GAUSS
 1t = 10,000 g Earth‟s magnetic Field =
  0.05 mt / 0.5 g
 Emf used in MRI = 0.15 – 1.5t
 1 t = 10,000 x earth‟s magnetic Field.
ADVANTAGES
1.   Non-ionizing
2.    Non- invasive
3.    Excellent soft tissue imaging with high
     Contrast sensitivity.
4.   Transverse, saggital, coronal, oblique
     Images obtained without repositioning the
     patient.
5.   No bone or air artifacts.
6.   Equipment contains no moving objects
7.   Exposure of humans to static magnetic
     Field < 2.5 t has no adverse effects.
DISADVANTAGES
 Expensive ( 6500 – 9000/= per scan )
  Available only in large set ups
  Needs trained staff
  Claustrophobic
  Long scanning time
  Movement artifacts
  Hard tissue details- difficult
  Absolutely contraindicated in patients with
  cardiac pacemakers, cerebral aneurism clips.
 9. Joint & ear prosthesis, insulin pumps, distort
  the image
 10. Not used in pregnancy
BIOEFFECTS of MRI
Reversible abnormalities may include:
 ↑ amplitude of T wave on an ECG due to
  magnetic hydrodynamic effect
 Heating of patients
 Fatigue
 Headaches
 Hypotension
 irritability
Time varying bioeffects may include:
 Light flashes in the eyes
 Alterations in the biochemistry of cells
  and fracture union
 Mild cutaneous sensations
 Involuntary muscle contractions
 Cardiac arrythmias
Projectiles

   The projectile effect of a metal object
    exposed to the field cans seriously
    compromise the safety of anyone sited
    between the object and the magnet
    system.
Metallic implants and prostheses
 Intracranial aneurysm clips
 Cardiac pacemakers
 Prostheic heart valves
 Cochlear implants
 Intraocular ferrous foreign bodies
 Orthopaedic implants
 Abdominal surgical clips
MRI IN TMJ DISORDERS
INDICATIONS
 To depict location, morphology &
  function of articular disc thus allowing
  diagnosis of internal derangement to be
  made.
 2. In cases of bone marrow edema, joint
  effusion, fibrous adhesions & certain
  tumors.
 3. Some osseous changes can be
  evaluated.
TECHNIQUE
   Patient is asked to remove all the metallic objects like hair pins, watches,
    ornaments, Credit cards.
   Patient is placed in supine position on removable table which is inserted into
    the magnet. Syringes of various sizes or commercially available bite blocks
    are used to stabilize the jaws in open mouth views.
   M.R.I is performed using body coil as transmitter and 2 surface coils as
    receiver. Surface coil improves spatial resolution and diagnostic details.
    Surface coil is placed adjacent to the structure being imaged.
   Patient and surface coil must be secured and motionless during image
    acquisition.
   Surface coils of diameter 6-12 cms provides optimal signal to noise ratio.
   Use of dual surface coil technique for imaging left and right TMJ at the same
    time is of great value because time on scanner can be reduced for bilateral
    TMJ imaging.
   Bilateral abnormalities are seen in up to 60% of patients with pain and
    dysfunction who initially present with unilateral symptoms.
      - Slice thickness of 3 mm or less is taken
STANDARD PLANES
   Oblique saggital
   Oblique coronal
   Images are taken perpendicular & parallel to long axis of
    condyle.
   Saggital Images should be obtained in both open and closed
    mouth positions to determine the function and position of disk in
    respect to condyle.
   Normal disk position is when posterior band is superior to
    condylar head in closed mouth position.
   In open mouth view- disk can be seen to be interposed between
    condyle and articular eminence (normal or reducing) or is
    anterior to the condyle (non-reducing).
   Coronal Images are taken only in closed mouth position. It
    gives better view of medial and lateral disk displacement.
    Osseous anatomy of condyle is better appreciated in coronal
    plane. Proton density images provide better view than T1 images
    for outlining the morphology.
MRI findings in normal TMJ
   Soft tissues of TMJ can be appreciated nicely by MRI images. Low intensity
    signal of normal meniscus makes it easily distinguishable from adjacent soft
    tissues of increased signal intensity.
   Saggital view: Open & Closed mouth
   - Normal disc is biconcave with posterior band lying superior to condylar head.
   - Because fibrous connective tissue of disc has low signal. Disc is usually
    distinguished from surrounding structures of high signal intensity.
   - Cortices of condylar & temporal components of joint appear dark because of
    low signal.
   - Posterior attachment has relatively more signal intensity compared to
    posterior part of disc because of more fatty tissue in posterior attachment.
   - M.R.I is the only modality that allows disc to be distinguished from post
    attachment.
   Coronal view:
   Normal disc is crescent shaped. In this view, disruption of disk .i.e. morphology
    or position of disc relative to condyle and articular eminence can be clearly
    visualized.
Significance of MRI in TMJ
disorders
 Internal Derangement
 Disc Displacement
 Disc Deformation
 Pseudodisc
 Joint Effusion
 Fibrous Adhesions
 Muscle Atrophy
 Tumors
 Post Surgical Imaging
CT SCAN                                             MRI
Computed (Axial) Tomography                      Magnetic Resonance Imaging
Sited for hard tissue evaluation                 Suited for Soft tissue evaluation
Uses X-rays for imaging                          Uses large external field, RF pulse and 3
                                                 different gradient fields
Usually completed within 5 minutes. Actual       Scanning typically run for about 30 minutes.
scan time usually less than 30 seconds.
Therefore, CT is less sensitive to patient
movement than MRI.
Despite being small, CT can pose the risk of     No biological hazards have been reported with
irradiation. Painless, noninvasive.              the use of the MRI.
Patients with any Metal implants can get CT      Patients with Cardiac Pacemakers are not
scan.                                            allowed to get MRI scan, tattoos and metal
                                                 implants may be contraindicated due to
                                                 possible injury to patient or image distortion.
Intravenous contrast agents- iodine based.       Very rare allergic reaction. Risk of nephrogenic
Allergic reaction is rare but more common than   systemic fibrosis with free Gadolinium in the
MRI contrast.                                    blood and severe renal failure.
Comparatively cheaper.                           More expensive.
REFERENCES



   Oral Radiology- Principles and Interpretation-
    White and Pharoah 5th Edition.

   Textbook of Dental and Maxillofacial
    Radiology- Freny R Karjodkar 2nd Edition.
• Eric Whaites- Essential of   Dental Radiology .

•Textbook of Oral Radiology- Ghom

• MRI at a Glance- Catherine Westbrook, 2nd Edition.

• MRI of the Musculoskeletal System
           By Martin Vahlensieck, Harry K. Genant, Maximilian Reiser

• TMJ Disorders and Orofacial Pain: The Role of Dentistry in a Multidisciplinary Diagnostic
Approach
            By Axel Bumann, Ulrich Lotzmann, James Mah
• Carl W,Hardin MD et al: Infection and tumours of the masticator space. Computed tomography
evaluation. Radiology 1985;157:413-17.

• Alan Schwimmer; S E Roth; S N Morrison: The use of computerized tomography in the
diagnosis and management of temporal and infratemporal space abscesses. Oral Surg Oral med
oral pathol 1988;66(1):17-20.

• Nick Bryan R et al: Computed tomography of major salivary glands. Am J Roentgenol
1982;139:547-54.

• Frame JW, Michael JC, Wake MB: CAT in the assessment of mandibular keratocysts. Br Dental
J 1982;153-93.
•Osborn et al: Normal and pathologic computed tomography anatomy of mandible. Am J Roentgenol
1982;139:555-59.

•Close LG, Merkel M et al: Computed tomography in the assessment of mandibular invasion by intraoral
carcinoma. Ann Otol RhinolLAryngol 1986;95(4-1):383-88.

•Cohen MA et al: Radiological features including those seen with computed tomography of central giant cell
granuloma of the jaws. Oral Surg Oral PAthol Oral Med 1988;65:255-61.

•Ariji Y et al: Florid cemento-osseous dysplasia radiographic study with special emphasis of computed tomography.
Oral Surg Oral Pathol Oral Med 1994;78(3):391-96.

•Brenna Betti N, Bruno E et al: Neoplasms of the maxillary sinus- the clinico-radiological considerations of dental
interest. Minerva Stomatol 1993;42(3):87-91.

•Colin P, Hodson N: Computed tomography of paranasal sinus tumours. Radiology 1979;132:641-45.

• Wang EY, Fleisher KA. MRI of temporomandibular joint disorders. Applied Radiol 2008;37(9):17-25.

•Belkin BA, Papageorge MB, Fakitsas J, Bankoff MS. A comparative study of magnetic resonance imaging versus
computed tomography for the evaluation of maxillary and mandibular tumors.J Oral Maxillofac Surg. 1988
Dec;46(12):1039-47.

•Harms SE, Wilk RM, Wolford LM, Chiles DG, Milam SB. The temporomandibular joint: magnetic resonance
imaging using surface coils.Radiology. 1985 Oct;157(1):133-6.

•Katzberg RW, Bessette RW et al. Normal and abnormal temporomandibular joint: MR imaging with surface coil.
Radiology. 1986 Jan;158(1):183-9.
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Basics of CT & MRI

  • 1. BASICS OF CT & MRI
  • 3. INTRODUCTION  OVER the last 40 years an array of imaging modalities has been developed that has enhanced the already versatile x-ray generating equipment and film used in conventional image production.  computed tomography was developed in the early to mid 1970s and is a radiographic technique for producing cross-sectional tomographic images.  Claimed to be 100 times more sensitive than conventional x-ray systems, it demonstrated differences between various soft tissues never before seen with x- ray imaging techniques.
  • 4. HISTORY  1961-Oldendorff W.H recognized the potential of reconstruction tomography.  1963- Cornmark used a source and detector rotate around a non symmetrical phantom and a computed for processing the transmission data.  1972- Godfrey Hounsfield an engineer at EMI(Electrical musical instruments) limited, England announced the invention of a revolutionary imaging technique which he referred to as Computerized Axial Transverse Scanning..
  • 5.  With this technique he was able to produce an axial cross-sectional image of the head using a narrowly collimated ,moving beam of X-rays.  1979-Cornmack and Hounsfield were awarded the Noble prize in Physiology and Medicine.  From 1971to 1975 ,within a span of 4 years, four generation of scanner evolved, which yielded shorter times and better control over the patient‟s motion.  In fifth generation CT scanner, scanning time is reduced to 16 milliseconds.  1998- CBCT was invented 
  • 6.  Synonyms;  Computerized Axial Tomography  Computerized Reconstruction  Computerized Tomographic Scanning  Axial Tomography  Computerized transaxial Tomography
  • 7. TOMOGRAPHY  Tomography is a process by which an image layer of the body is produced, while the images of the structures above and below that layer are made invisible by blurring.
  • 8. Tomography may be classified into many types:  Conventional Tomography  Computed Tomography  Three - dimensional C T  Spiral Computed Tomography  Emission Computed Tomography
  • 9. Conventional Tomography  Tomography is a generic term, formed from the Greek words tomo (slice) and graph (picture) that was adopted in 1962 by the International Commission on Radiographic Units and Measurements to describe all forms of body section radiography.
  • 10. This is achieved by a synchronized movement of the film and the tube in opposite directions, about a fulcrum (i.e. the plane of interest in the patient's body). Objects closest to the film are seen most sharply and objects farthest away are completely blurred.  The thickness of the image layer depends on the angle of rotation or the amount of movement of the tube.  Some degree of image degradation also occurs within the image layer. The greatest amount of blurring is at the periphery of the image layer, and the sharpest image is at the center
  • 11.
  • 12.
  • 13.
  • 14. Computed Tomography (CT)  A computed tomographic image is a display of anatomy of a thin slice of body developed from multiple X-ray absorption measurements made around the body's periphery.
  • 15.  Computed tomography (CT) permits the imaging of thin slices of tissue in a wide variety of planes.  Most CT is done in the axial plane, and many CT scans also provide coronal views; sagittal slices are less commonly used.
  • 16. Slice thickness is usually 10 mm through the body and brain  5 mm through the head and neck, unless three dimensional reconstruction is anticipated.  In such cases, the slice thickness is 1.0 to 1.5 mm in order to provide adequate data
  • 17. BASIC PRINCIPLE  CT scanners use the X-rays to produce the sectional or slice images ,as in conventional tomography, but radiographic film is replaced by sensitive detectors. The detectors measure the intensity of the x-ray beam emerging from the patient and convert this into digital data which are stored and can be manipulated by a computer. This numerical information is converted into a gray scale representing different tissue densities ,thus allowing a visual image to be generated.
  • 19. 1. First generation (Rotate / Translate, pencil beam)  The original EMI unit was the first generation scanner. It was rotate/translate pencil beam system. Only two detectors were used, which measured transmission of X-ray through the patient for two different slices. That is two tomographic sections were taken simultaneously. It was designed specifically for evaluation of brain. In this unit head was enclosed in a water bath.  The linear motion was repeated 180 times and after one linear movement ,gantry rotated 1 degree.  X-ray beam was on during linear motion ,while off during rotation.  The transmitted radiation was 160 times during each linear movement .  Total no. of transmission-160x180= 28,800  Scan time was 4.5 to 5 min.  Matrix was 80x80
  • 20.
  • 21.  Second generation (Rotate / Translate, narrow fan beam)  Second generation scanner were also of translate- rotate type. These units were incorporated a linear array of 30 detectors. The use of 30 detectors increased the utilization of the X-ray beam by 30 times over the single detector used per slice in first generation systems. Source detector assembly intercepting a fan shaped (a narrow fan angle of 10°) beam rather than a pencil sized X-rays beam.  Instead of moving 1 degree at the end of each linear scan ,the gantry rotates through a greater arc, upto 30 degree. So linear movement have to be repeated six times to cover 180 degree.  Scan time was 10-90 sec.
  • 22.
  • 23.  Third generation (Rotate/rotate wide fan beam)  The translation motion of first and second generation was a major limitation because at the end of each translation, the translational inertia of X-ray tube/detector system had to be stopped; the whole system rotated and then the translation motion had to be restarted. This design could never have led to fast scanning.  To overcome this limitation third generation scanners evolved. Third generation scanner uses increased number of detector (upto about 750 detector) and rotate-rotate system i.e. X-ray tube and detector array were rotated. The detector is aligned around an area of a circle whose centre is focal spot. X-ray beam is collimated into fan beam (fan angle was about 50°).  Scan time was 2 to 10 sec.
  • 25.  Cone Beam Radiology  CBCT uses a round or rectangular cone – shaped x-ray beam centered on a two – dimensional x-ray sensor to scan a 360 degree rotation about the patient‟s head. During the scan a series of 360 exposures or projections, one for each degree of rotation, is acquired, which provide raw digital data for reconstruction of the exposed volume by computer algorithm.
  • 26. Depending on the equipment, scan time range from 17 sec to little more than 1 min.  Multiplanar reformatting of the primary reconstruction allows for both three- dimensional and two-dimensional images of any selected plane to be made.  Resolving power is four times that of CT  Less expensive  Radiation dose is 3-20 % that of conventional CT.
  • 27. Fourth generation CT scanner (rotate /stationary)  Fourth generation CT scanner were designed to overcome the problem of electronic drift between many detectors used in the system so this design eliminated ring artifact.  Fourth generation CT scanner uses rotate only motion. Huge tube rotated but the detector assembly does not. The detector forms a ring that completely surrounds the patient. The X-ray tube rotates in a circle inside the detector ring and X- ray beam was collimated to form a fan beam.  Was not faster in principle than third generation.  Easier detector calibration.
  • 28.  4th generation configuration
  • 29.  Fifth generation systems-  Developed by Dr. E Woods of Mayo Clinic. System consists of multiple rays tubes and detectors. Such a unit is primarily used to image 3D sections of the heart and reduces artifacts caused due to cardiac rhythm.
  • 30. CT EQUIPMENT The equipment consist of:  Gantry containing x-ray source, detectors and electronic measuring devices  Motorized table- used to position the patient within gantry  X-ray power supplies and controls  Computer  Viewing devices
  • 31.
  • 32. X-RAY TUBES  Radiation source for CT would supply monochromatic X-ray beam by which image reconstruction is simple and more accurate.  Earlier models used oil-cooled, fixed – anode, relatively large (2x16mm)focal spot tubes at energies of about 120 kilovolt (constant potential) and 30mA. The beam was heavily filtered to move low energy photons and to increase the mean energy of the radiation.
  • 33. Most newer fan beam units have a diagnostic –type x-ray tube with a rotating anode and a much smaller focal spot ,in some units down to 0.6mm and generate X-rays in short bursts, or pulses. These tubes are air-cooled and operate at much higher currents, upto 600mA. They are (cathode-anode ) perpendicular to the fan beam to avoid asymmetry in X-ray output because of the heel effect.
  • 34. Recently, special types of X-ray tubes have been developed for CT. These tubes are designed to withstand the very high heat loads generated when multiple slices are acquired in rapid sequence.
  • 35. COLLIMATORS  The x-ray beam is collimated at two points ,one close to the x-ray tube and the other at the detector.  The collimator at the detector is the sole means of controlling scatter radiation.  The collimators also regulate the thickness of the tomographic section(voxel length)
  • 36. Detectors- 1.Gas filled ion chamber detectors made of high pressure xenon. Capture about 50 % photons in the beam 2. Solid state detector commonly used, 80% efficient. Usually made of cadmium tungstate.
  • 37. TECHNIQUE image The process by which production of CT occur is called scanning.  The patient lies down with the part of the body to be examined within the circular gantry, housing the X-ray tube head and detector.  The level of plane and thickness of the section to be imaged are selected and x-ray tube head rotates around the patient, scanning that section.  As the tube head rotate around the patient each set of detector produces an attenuation or penetration profile of the region of the body being examined.
  • 38. These detectors produce electrical impulses that are pro-portional to the intensity of the X-ray beam emerging from the body  That intensity is determined by various factors; 1. the energy of the X-ray source, 2. the distance between the source and the detector 3.the attenuation of the beam by the material in the object being scanned.  Penetration profile is stored in the computer, which calculates the density or absorption at points on a grid formed by the intersections of penetrating profiles.  The CT image is a digital image, reconstructed by the computer, which mathematically manipulates the transmission data obtained from the multiple projections
  • 39. The image consists of a matrix of individual blocks called voxels (volume element).It consist of an array of individual points or pixels.  The size of the pixel is determined by:  The geometry of the scan,  The frequency and spacing of measurements,  The number of penetration profiles and  The size of the x-ray source and detector  Each pixel is assigned a CT number or Hounsfield unit(HU) between +1000 to -1000, depending upon the amount of the absorption within that block of tissue.
  • 40.  Each number or pixel represents a calculation of the actual attenuation of the X-ray beam by materials with the body. It represents the absorption characteristics or linear attenuation coefficient of that particular volume of tissue in the patient.
  • 41.  IMAGE RECONSTRUCTION  Images are typically 512 x 512 or 1024 x 1024 pixels.  Rapid image reconstruction done by Two-dimensional Fourier Analysis Filtered back projection
  • 42. CT numbers for various body tissues. Absorber CT number/HU Bone (dense) +400 to +1000 Soft tissues +40 to +80 Water 0 Fat -60 to -100 Lung -400 to -600 Air -1000
  • 43.  The computer can construct an image by printing the numbers or assigning different degree of greyness to each CT number. In some system ,the numerical values are translated into colours or brightness level that can be displayed on a television screen or printed on a paper.
  • 44. Image display-----In two basic mode  As a paper printout of CT numbers  As a gray scale image on a cathode ray tube or television monitor.
  • 45.  WINDOW LEVEL AND WINDOW WIDTH  These two variables enable the visual image to be altered by selecting the range and level of densities to be displayed.  Window level-is the CT numbers selected for the centre of the range depending on weather the lesion under investigation is in the soft tissue or bone.  Window width-is the range of CT numbers selected for various shades of grey.
  • 46.  The contrast and brightness of the image may be adjusted as necessary although the images are usually viewed in two modes:  Bone windowing and soft-tissue windowing.  In Bone windowing, the contrast is set so that osseous structures are visible in maximal detail.  With soft-tissue windowing, the bone looks uniformly white, but various types of soft tissues can be distinguished.
  • 47. DISTORTION A signal can contain errors or distortions that are repeatable (deterministic). For instance, if a patient moves during the acquisition step, parts of the anatomy may be blurred or in different positions from their true location. If the image reconstruction process requires linear and consistent data, but the measurements for some reason are not consistent, artifacts can arise that may result in lost information or spurious image features.
  • 48. ARTIFACT  Any discrepancy between the CT numbers represented in the image and the expected CT number based on the linear attenuation coefficient
  • 49.  IMAGE ARTIFACTS 1. Partial volume artifact 2. Beam hardening artifact  (due to absorption of low energy photon from the beam.) 3. Metal artifacts
  • 50. METAL ARTIFACT  MANIFEST AS “STAR STREAKING” ARTIFACT.  CAUSED BY PRESENCE OF METALLIC OBJECTS INSIDE OR OUTSIDE THE PATIENT.  METALLIC OBJECT ABSORBS THE PHOTONS CAUSING AN INCOMPLETE PROFILE
  • 52. CONTRAST MEDIA  Is used to obtain a differential change in the attenuation values of normal and pathologic tissues so that recognition of pathology is facilitated. one can expect a large variety of contrast enhancement in pathological tissues due to tissue alterations, mainly related to differences in vascular contrast distribution volume and total distribution volume.  Iodine based  iodine monomers- iothalmate, diatrizoate, metrizoate  Non ionic monomer like iopamidol ,iotrioxol
  • 53. INDICATIONS  Intracranial diseases and trauma  Malignancy of jaws  Infection  Post-irradiation  Salivary gland  Temporomandibular joint  Implants  Fracture  Foreign body  Imaging of unerupted and displaced teeth, bone grafting.
  • 54. Advantages  Cross-sectional imaging  Superior contrast and resolution  Geometric accuracy  Images can be manipulated  Axial tomographic sections are obtainable  Images can be enhanced by the use of i.v contrast media, providing additional information.
  • 55. Disadvantages  Expensive  Facilities are not widely available  Very thin contiguous or overlapping slices may result in a high dose of radiation.  Geometric miss  Metallic objects such as fillings produce marked streak artifacts across the CT image.
  • 56. Recent advances in CT 3 DIMENSIONAL CT-  in this data obtained from CT scan is reformatted into 3D images.  3D CT requires that each voxel, shaped as rectangular parallel piped or rectangular solid be dimensionally altered into multiple cuboidal voxels. This process, called interpolation creates sets of evenly spaced cuboidal voxels (cuberilles) that occupy the same volume as the original voxel.  The CT numbers of the cuberilles represent the average of the original voxel CT numbers surrounding each of the new voxel.  Creation of these new cuboidal voxels allows the image to be reconstructed in any plane without loss of resolution by locating their position in space relative to one another.
  • 57. Ultrafast CT: I matron (San Francisco) has developed a CT scanner capable of acquiring the data upto 10 times faster than conventional CT. About 50msec is able to freeze cardiac and pulmonary motion, enhancing the quality without motion artifact.  Spiral CT scanners: (discovered in 1989) in this while the gantry containing the x-ray tube and detectors revolve around the patient, the patient table continuously advances through the gantry. This results in the acquisition of a continuous spiral of data as the x-ray beam moves down the patient. Advantage  Improved multiplanar image reconstruction  Reduced examination time(12sec vs 5 min)  Reduced radiation dose(<75%)
  • 58. Helical CT is now standard.  In helical CT scanners, pitch refers to the amount of patient movement compared with the width of image acquired. table travel per X-ray tube rotation  Pitch= image thickness
  • 59. Multidetector helical CT (MDCT, multislice CT, or multirow CT)  Introduced in 1998  Widely used  With this method ,anywhere from four to 64 adjacent detector arrays are used in conjunction with helical CT.  Time for full cycle rotation-0.35sec.  The quality of axial ,reformatted, and three dimensional images ,also improved with this as compared to single-slice machines.
  • 60. Electron beam CT– recent development  In this machine an electron gun generates an electron beam that is focused electrostatically on a fixed tungsten target circling halfway around the patient.  The X-rays that are generated expose the detector array circling the other half of the patient.  Because there are no moving parts ,an image may be acquired in less than 100 microseconds.  This technique is primarily used for cardiac imaging to stop heart motion.
  • 61. Emission CT- is similar in principle to x- ray transmission CT .instead of section morphology ,it reflects physiological processes that concentrate the radionuclide in one or more organs or body compartments.
  • 62. CBCT CT Less radiation dose More More time Less Images are of lower Higher contrast Slice thickness 0.1 1-2 mm mm Less expensive More
  • 63. SIGNIFICANCE OF CT IN MAXILLOFACIAL REGION  Trauma  Neoplasms  Inflammatory processes  TMJ disorders
  • 64. Odontogenic infections  Cellulitis- soft tissue swelling obliterating fat planes.  Abscess- irregular zone of low density with a peripheral rim of contrast enhancement.  Acute osteomyelitis- zone of increased contrast enhancement.  Chronic osteomyelitis- destructive pattern with peripheral rim of contrast enhancement.
  • 65. Carl W Hardin and RIC Harnsberger (1985) made use of CT in evaluation of infections and tumours involving the masticator spaces and found that CT is helpful in differentiating inflammation from frank abscesses. Alan A Schwimmer et al (1988) emphasized the role of CT in the diagnosis and management of temporal and infratemporal space abscesses.
  • 66. Sialadenitis  CT is non-invasive, painless and less time-consuming.  Non-contrast CT for detecting calculi.  Contrast CT for abscess/cellulitis  Salivary calculi seen as high density, non- contrast enhancing mass along the course of the duct.
  • 67. Nick Bryan et al performed CT in 27 patients with salivary gland neoplasm and concluded that when CT is combined with the clinical information and laboratory findings, the overall specificity in identifying the tumour becomes 90%.
  • 68. ODONTOGENIC CYSTS  Appear as localized, expansile degenerative area having a fluid density throughout the lesion.  Do not show contrast enhancement in contrast aided imaging (except Aneurysmal Bone Cyst).
  • 69. John W Frame and Michael JC Wake evaluated mandibular keratocysts with CT and established that CT provides better methods of accurately displaying the margins of the keratocysts, the areas of bony perforation and any extension into soft tissues.
  • 70. ODONTOGENIC TUMOURS  Appear as an expansile lesion having a soft tissue density which show moderate enhancement in contrast aided imaging (except cemental tumours).  Foci of cystic degeneration are commonly seen.  Show breach in cortical plates.  Foci of calcifications are noticed in maturing odontogenic tumours.
  • 71.  Ameloblastomas- bicortical expansion, thinning and breach of bony walls, extension of tumour into adjacent soft tissue spaces.  Focal cystic degenerations commonly seen in multilocular lesions.  Plexiform ameloblastomas have high contrast enhancement due to high vascularity.  Cystic ameloblastomas show a predominant fluid density.  Malignant ameloblastomas have a grossly destructive pattern.  Focal hyperdense areas suggesting calcifications maybe noticeable in Pindborg tumour.
  • 72. Osborn et al (1982) made a study, on imaging of several mandibular tumours and established their osseous and soft tissue extensions. CT was found valuable in excluding the involvement of mandible by primary osseous and soft tissue lesions of adjacent areas.
  • 73. MALIGNANCIES  Seen as predominantly destructive lesions interspersed with focal high contrast enhancement areas.  Invasive lesions show no/minimal expansion.  Demarcation from surrounding soft tissue is difficult without contrast aided imaging.  Reparative lesions like central giant cell granulomas also manifest as destructive, contrast enhancing lesions showing minimal or no expansile pattern.
  • 74. Close LG et al (1986) found a critical factor in the pretreatment evaluation of patients with carcinoma of the oral cavity or oropharynx, the presence or absence of bony invasion. CT was more specific than conventional X-ray films in detecting bone invasion. Mark A Cohen and Yancu Hertzanu (1988) in their study on CGCG using CT, conventional tomogram and conventional radiographs, proved CT to be superior in clearly demonstrating the soft tissue mass of lesion, its extension into adjacent structures and bony destruction.
  • 75. Fibro-osseous lesions  CT pattern depends on the maturative stage of lesion.  Cemental lesions are distinguished based on the continuity of the lesions with the roots of the tooth and the periodontal ligament space, separating the lesion from the bony alveolus.
  • 76. Ariji Y et al (1994) studied cases of florid cemento-osseous dysplasia with conventional radiography and CT and observed thin, low density areas around high density masses with expansion of buccal and lingual cortical plates. CT was able to give additional information by identifying the density of these masses which ranges from 772-1582 HU. These values were suggestive of cementum or cortical bone.
  • 77. MAXILLARY LESIONS  Maxillary lesions share similar pictures in contrast to mandibular lesions which make this difficult to distinguish them.
  • 78. Brenna Betti N, Bruno E et al (1993) For early diagnosis of the maxillary antrum carcinoma, besides a conventional radiographic test, also of more specific analysis, as the computed tomography and radio therapy. Colin P and Hodson N. Thirty-two patients with histologically proved malignant disease involving the paranasal sinuses were studied by CT. Significantly greater tumor extent was demonstrated by CT than by conventional methods.
  • 79. TMJ  CT helps identify the bony changes in the TMJ like destruction of the condylar head, wearing of articular elements, traumatic lesions within and outside the capsule.  Advantageous over arthrography as it is a painless procedure with superior resolution.
  • 80. conclusion  CT scan has made a major impact on the practice of dentistry, particularly in oral and maxillofacial diagnosis, surgery and management of a wide variety of oral lesions. Advances in computer softwares already allow 3 D visualization of anatomy and pathology, but further improvement in clinical performance is expected.
  • 82. Here, radiant energy is in the form of radiofrequency wave rather than X-ray.  Father of MRI- Felix Bloch
  • 83. TYPES OF ATOMIC MOTION 1. The electron orbits the nucleus 2. The electron spins on its own axis 3. ***The nucleus spins on its own axis***
  • 84. MRI USES THE HYDROGEN ATOM •1 electron orbits the nucleus •The nucleus contains no neutrons but contains 1 proton THE HYDROGEN NUCLEUS HAS A NET POSITIVE CHARGE •Hydrogen nucleus is a spinning, positively charged particle
  • 85. LAW OF ELECTROMAGNETISM •A charged particle in motion will create a magnetic field •The postitively charged, spinning hydrogen nucleus generates a magnetic field WHY HYDROGEN? •Very abundant in the human body-H20 •Has a large magnetic moment
  • 86. MAGNETIC MOMENT The tendency of an MR active nuclei to align its axis of rotation to an applied magnetic field MR ACTIVE NUCLEI odd # protons or odd # neutrons or BOTH e.g. Hydrogen1, Carbon13, Nitrogen15, Oxygen17, Fluorine19, Sodium23, Phosphorus31 STABLE ATOMS # protons = # electrons IONS # protons # electrons
  • 87. When a body is placed into the bore of the scanner, the strong magnetic field will cause the individual hydrogen nuclei to either: A) ALIGN ANTI-PARALLEL TO THE MAIN MAGNETIC FIELD (B0) OR B) ALIGN PARALLEL TO THE MAIN MAGNETIC FIELD (B0) Anti-parallel high energy B0 NMV Parallel low energy
  • 88.
  • 89. NET MAGNETIZATION VECTOR  An excess of hydrogen nuclei will line up parallel to B0 and create the NMV of the patient
  • 90. N N S S size direction The magnetic vector
  • 91. THE NUCLEI WILL ALSO PRECESS…
  • 92. PRECESSION  Due to the influence of B0, the hydrogen nucleus “wobbles” or precesses (like a spinning top as it comes to rest)  The axis of the nucleus forms a path around B0 known as the “precessional path”
  • 93. PRECESSION  The speed at which hydrogen precesses depends on the strength of B0 and is termed the “precessional frequency”  The precessional frequency of hydrogen in a 1.5 Tesla magnetic field is 63.86 MHz  The precessional paths of the individual hydrogen nucleus‟ is random, or “out of phase”
  • 94.  The spinning protons wobble or “precess” about that axis of the external Bo field at the precessional, Larmor or resonance frequency.  Magnetic resonance imaging frequency ω= Bo where is the gyromagnetic ratio The resonance frequency ω of a spin is proportional to the magnetic field, Bo.
  • 95. WE NEED THEM TO BE “IN- PHASE” OR TO RESONATE…
  • 96. RESONANCE Occurs when an object is exposed to an oscillating perturbation that has a frequency close to its own natural frequency of oscillation
  • 97. RADIOFREQUENCY ENERGY  Follows the Law of Electromagnetism (charged particles in motion will generate a magnetic field)  Magnetic field known in MR as B1  Applied as a “pulse” during MR sequences  The RF pulse is applied so that B1 is 90 to B0
  • 98.
  • 99. DURING RESONANCE… 1) The hydrogen atoms begin to precess “in phase” 1)
  • 100. 2)The hydrogen atoms align with the RF‟s magnetic field (B1) and they flip!!
  • 101.
  • 102. AS THE NUCLEI PRECESS IN-PHASE IN THE B1 PLANE, A CHANGING MAGNETIC FIELD IS CREATED IF YOU PLACE A RECEIVER COIL (ANTENNA) IN THE PATH OF THE CHANGING MAGNETIC FIELD, A CURRENT WILL BE INDUCED THIS IS FARADAY’S LAW OF INDUCTION
  • 103. FARADAY’S LAW OF INDUCTION A changing magnetic field will induce an electrical current in any conducting medium COILS Used to: •transmit pulses of radiofrequency energy •receive induced voltage - MR SIGNAL •increase image quality by tuning in to one body part at a time
  • 104. RELAXATION When the RF pulse is turned “off”, the NMV “relaxes” back to B0 (away from B1) NMV B0 B1
  • 105. DIFFERENT TYPES OF COILS  Gradient Coils  Radiofrequency Coils  Shim Coils
  • 106. GRADIENT COILS  Three types as per cartesian coordinate system- for x, y and z axis; „slice selection gradient‟, „phase-encoding gradient‟ and „frequency-encoding gradient‟.  Slice location is selected by frequency of the RF pulse while the thickness is selected by the bandwidth.
  • 107. RADIOFREQUENCY COILS  For transmitting and receiving signals at the resonant frequency of the protons within the patient
  • 108. Types of RF Coils  Transmit Receive  Volume Coil Coil  Surface Coil  Receive Only Coil  Gradient Coil  Transmit Only Coil  Multiply Tuned Coil
  • 109. MR SIGNAL  Collected by a coil  Encoded through a series of complex techniques and calculations (magic?)  Stored as data  Mapped onto an image matrix
  • 110. TR - REPETITION TIME Time from the application of one RF pulse to another RF pulse TE - ECHO TIME Time from the application of the RF pulse to the peak of the signal induced in the coil
  • 111.
  • 112. T1 WEIGHTING •A short TR and short TE will result in a T1 weighted image •Excellent for demonstrating anatomy T2 WEIGHTING •A long TR and long TE will result in a T2 weighted image •Excellent for demonstrating pathology MANY OTHER DIFFERENT TYPES OF IMAGES THAT COMBINE ABOVE AND INCLUDE OTHER PARAMETERS
  • 113.  If TR and TE are less (100-500/20ms), image contrast is due to differences in T1 relaxation time and we get T1 weighted image.  Used to view anatomic details because of increased contrast.  T1 images are also called FAT IMAGES because fat has shortest T1 relaxation time. Therefore high signal and bright image.
  • 114.  If TR and TE are more 2000 ms/80 ms, we get T2 weighted image. It is used for inflammatory changes, tumors, joint effusions perforations.  T2 are WATER IMAGES because water has longest T2 relaxation time. Therefore produce high signal and bright image.
  • 116. MR using Contrast Medium  Lesions with increased blood permeability demonstrate higher signal intensity than that of normal tissue on T1-weighted images.
  • 117. CONTRAST AGENTS  Most commonly used- Gadolinium.  Administered intravenously to improve tissue contrast.  Shortens the T1 relaxation times of enhancing tissues, making them appear brighter.  Could be a cause of nephrogenic systemic fibrosis in some patients with renal dysfunction.
  • 118. MR Angiography  For detection of vessel systems esp. carotid arteries and their branches.  No contrast agents are injected.  Vessels with flow appear as bright homogenous linear structures on MRA.  Static tissues appear blurred.  2 widely available MRA methods are- time of flight (TOF) and phase-contrast (PC) approaches.
  • 119. MR Sialography  Requires no cannulation, contrast or ionizing radiation!  Suitable for patients even with acute inflammation.  This technique is more useful for salivary gland ducts.  Virtual endoscopy using MR sialographic imaging data enables depiction of inner surfaces of parotid and submandibular ducts.
  • 120. MR Cisternography  No lumbar puncture, contrast medium or ionizing radiation!  Cisterns of the brain are demonstrated as high signal intensity structures that coincide with the shape of the cistern.  Invaluable for ruling out brain tumours in patients with trigeminal neuralgia.
  • 121. Functional MRI  New tool for evaluating specific hypothesis concerning the anatomical regions of the human brain involved in processing sensory and motor information.  Small signal changes appear hyperintense on fMRI; these are related to alterations in blood oxygenation levels and therefore changes in the magnetization of protons within the blood.  Enable identification of motor and sensory areas of brain related to oral functions eg. Occlusion.
  • 122. UNITS OF MAGNETIC FIELD  TESLA & GAUSS  1t = 10,000 g Earth‟s magnetic Field = 0.05 mt / 0.5 g  Emf used in MRI = 0.15 – 1.5t  1 t = 10,000 x earth‟s magnetic Field.
  • 123. ADVANTAGES 1. Non-ionizing 2. Non- invasive 3. Excellent soft tissue imaging with high Contrast sensitivity. 4. Transverse, saggital, coronal, oblique Images obtained without repositioning the patient. 5. No bone or air artifacts. 6. Equipment contains no moving objects 7. Exposure of humans to static magnetic Field < 2.5 t has no adverse effects.
  • 124. DISADVANTAGES  Expensive ( 6500 – 9000/= per scan )  Available only in large set ups  Needs trained staff  Claustrophobic  Long scanning time  Movement artifacts  Hard tissue details- difficult  Absolutely contraindicated in patients with cardiac pacemakers, cerebral aneurism clips.  9. Joint & ear prosthesis, insulin pumps, distort the image  10. Not used in pregnancy
  • 125. BIOEFFECTS of MRI Reversible abnormalities may include:  ↑ amplitude of T wave on an ECG due to magnetic hydrodynamic effect  Heating of patients  Fatigue  Headaches  Hypotension  irritability
  • 126. Time varying bioeffects may include:  Light flashes in the eyes  Alterations in the biochemistry of cells and fracture union  Mild cutaneous sensations  Involuntary muscle contractions  Cardiac arrythmias
  • 127. Projectiles  The projectile effect of a metal object exposed to the field cans seriously compromise the safety of anyone sited between the object and the magnet system.
  • 128.
  • 129. Metallic implants and prostheses  Intracranial aneurysm clips  Cardiac pacemakers  Prostheic heart valves  Cochlear implants  Intraocular ferrous foreign bodies  Orthopaedic implants  Abdominal surgical clips
  • 130. MRI IN TMJ DISORDERS
  • 131. INDICATIONS  To depict location, morphology & function of articular disc thus allowing diagnosis of internal derangement to be made.  2. In cases of bone marrow edema, joint effusion, fibrous adhesions & certain tumors.  3. Some osseous changes can be evaluated.
  • 132. TECHNIQUE  Patient is asked to remove all the metallic objects like hair pins, watches, ornaments, Credit cards.  Patient is placed in supine position on removable table which is inserted into the magnet. Syringes of various sizes or commercially available bite blocks are used to stabilize the jaws in open mouth views.  M.R.I is performed using body coil as transmitter and 2 surface coils as receiver. Surface coil improves spatial resolution and diagnostic details. Surface coil is placed adjacent to the structure being imaged.  Patient and surface coil must be secured and motionless during image acquisition.  Surface coils of diameter 6-12 cms provides optimal signal to noise ratio.  Use of dual surface coil technique for imaging left and right TMJ at the same time is of great value because time on scanner can be reduced for bilateral TMJ imaging.  Bilateral abnormalities are seen in up to 60% of patients with pain and dysfunction who initially present with unilateral symptoms.  - Slice thickness of 3 mm or less is taken
  • 133.
  • 134. STANDARD PLANES  Oblique saggital  Oblique coronal  Images are taken perpendicular & parallel to long axis of condyle.  Saggital Images should be obtained in both open and closed mouth positions to determine the function and position of disk in respect to condyle.  Normal disk position is when posterior band is superior to condylar head in closed mouth position.  In open mouth view- disk can be seen to be interposed between condyle and articular eminence (normal or reducing) or is anterior to the condyle (non-reducing).  Coronal Images are taken only in closed mouth position. It gives better view of medial and lateral disk displacement. Osseous anatomy of condyle is better appreciated in coronal plane. Proton density images provide better view than T1 images for outlining the morphology.
  • 135.
  • 136. MRI findings in normal TMJ  Soft tissues of TMJ can be appreciated nicely by MRI images. Low intensity signal of normal meniscus makes it easily distinguishable from adjacent soft tissues of increased signal intensity.  Saggital view: Open & Closed mouth  - Normal disc is biconcave with posterior band lying superior to condylar head.  - Because fibrous connective tissue of disc has low signal. Disc is usually distinguished from surrounding structures of high signal intensity.  - Cortices of condylar & temporal components of joint appear dark because of low signal.  - Posterior attachment has relatively more signal intensity compared to posterior part of disc because of more fatty tissue in posterior attachment.  - M.R.I is the only modality that allows disc to be distinguished from post attachment.  Coronal view:  Normal disc is crescent shaped. In this view, disruption of disk .i.e. morphology or position of disc relative to condyle and articular eminence can be clearly visualized.
  • 137. Significance of MRI in TMJ disorders  Internal Derangement  Disc Displacement  Disc Deformation  Pseudodisc  Joint Effusion  Fibrous Adhesions  Muscle Atrophy  Tumors  Post Surgical Imaging
  • 138. CT SCAN MRI Computed (Axial) Tomography Magnetic Resonance Imaging Sited for hard tissue evaluation Suited for Soft tissue evaluation Uses X-rays for imaging Uses large external field, RF pulse and 3 different gradient fields Usually completed within 5 minutes. Actual Scanning typically run for about 30 minutes. scan time usually less than 30 seconds. Therefore, CT is less sensitive to patient movement than MRI. Despite being small, CT can pose the risk of No biological hazards have been reported with irradiation. Painless, noninvasive. the use of the MRI. Patients with any Metal implants can get CT Patients with Cardiac Pacemakers are not scan. allowed to get MRI scan, tattoos and metal implants may be contraindicated due to possible injury to patient or image distortion. Intravenous contrast agents- iodine based. Very rare allergic reaction. Risk of nephrogenic Allergic reaction is rare but more common than systemic fibrosis with free Gadolinium in the MRI contrast. blood and severe renal failure. Comparatively cheaper. More expensive.
  • 139. REFERENCES  Oral Radiology- Principles and Interpretation- White and Pharoah 5th Edition.  Textbook of Dental and Maxillofacial Radiology- Freny R Karjodkar 2nd Edition.
  • 140. • Eric Whaites- Essential of Dental Radiology . •Textbook of Oral Radiology- Ghom • MRI at a Glance- Catherine Westbrook, 2nd Edition. • MRI of the Musculoskeletal System By Martin Vahlensieck, Harry K. Genant, Maximilian Reiser • TMJ Disorders and Orofacial Pain: The Role of Dentistry in a Multidisciplinary Diagnostic Approach By Axel Bumann, Ulrich Lotzmann, James Mah • Carl W,Hardin MD et al: Infection and tumours of the masticator space. Computed tomography evaluation. Radiology 1985;157:413-17. • Alan Schwimmer; S E Roth; S N Morrison: The use of computerized tomography in the diagnosis and management of temporal and infratemporal space abscesses. Oral Surg Oral med oral pathol 1988;66(1):17-20. • Nick Bryan R et al: Computed tomography of major salivary glands. Am J Roentgenol 1982;139:547-54. • Frame JW, Michael JC, Wake MB: CAT in the assessment of mandibular keratocysts. Br Dental J 1982;153-93.
  • 141. •Osborn et al: Normal and pathologic computed tomography anatomy of mandible. Am J Roentgenol 1982;139:555-59. •Close LG, Merkel M et al: Computed tomography in the assessment of mandibular invasion by intraoral carcinoma. Ann Otol RhinolLAryngol 1986;95(4-1):383-88. •Cohen MA et al: Radiological features including those seen with computed tomography of central giant cell granuloma of the jaws. Oral Surg Oral PAthol Oral Med 1988;65:255-61. •Ariji Y et al: Florid cemento-osseous dysplasia radiographic study with special emphasis of computed tomography. Oral Surg Oral Pathol Oral Med 1994;78(3):391-96. •Brenna Betti N, Bruno E et al: Neoplasms of the maxillary sinus- the clinico-radiological considerations of dental interest. Minerva Stomatol 1993;42(3):87-91. •Colin P, Hodson N: Computed tomography of paranasal sinus tumours. Radiology 1979;132:641-45. • Wang EY, Fleisher KA. MRI of temporomandibular joint disorders. Applied Radiol 2008;37(9):17-25. •Belkin BA, Papageorge MB, Fakitsas J, Bankoff MS. A comparative study of magnetic resonance imaging versus computed tomography for the evaluation of maxillary and mandibular tumors.J Oral Maxillofac Surg. 1988 Dec;46(12):1039-47. •Harms SE, Wilk RM, Wolford LM, Chiles DG, Milam SB. The temporomandibular joint: magnetic resonance imaging using surface coils.Radiology. 1985 Oct;157(1):133-6. •Katzberg RW, Bessette RW et al. Normal and abnormal temporomandibular joint: MR imaging with surface coil. Radiology. 1986 Jan;158(1):183-9.