This document provides an overview of cranial nerves, with a focus on the trigeminal nerve (CN V). It discusses the organization of the nervous system and related terminologies. It then describes each of the 12 cranial nerves and provides detailed information on CN V, including its sensory and motor roots, nuclei, and three divisions (ophthalmic, maxillary, mandibular). The document outlines the course and branches of each division of CN V.
3. CONTENTS
Introduction.
Organization of Nervous System.
Related Terminologies.
Cranial Nerves.
Detailed study of
V. Trigeminal nerve
VII. Facial nerve
IX. Glossopharyngeal nerve
X. Vagus nerve
XII. Hypoglossal nerve
References.
4. INTRODUCTION
The nervous system is the most important
organization which controls and integrates the
different bodily functions and likewise maintains a
stability of the internal environment despite
extreme changes in the external environment.
This system is absolutely necessary for the
reception , storage and release of different sensory
and motor informations for regulating or initiating a
particular behaviour of the individual.
It is a very complicated system; structures and
organs are specialised for different specific
purposes.
6. RELATED TERMINOLOGIES
NEURON:
It is the structural and
functional unit of the
nervous system and
consists of a nerve cell
body with all its processes.
7. NUCLEUS:
A mass of grey matter,
composed of nerve cells,
in any part of the brain or
spinal cord.
GANGLION:
It is a group of nerve
cell bodies situated
outside the brain and
spinal cord.
Cranial nerve nuclei as projected on to
the dorsal aspect of the brain stem.
8. TRACT:
A bundle or group
of nerve fibers in
the brain or spinal
cord.
NERVE:
A bundle of
neuronal
processes outside
the central nervous
system.
PLEXUS:
A network or
interjoining of
nerves.
9. VISCERAL NERVES:
Nerves which supply (or bring information from) the
different viscera, the organs within the body cavity.
These nerves are better known as autonomic nerves.
SOMATIC NERVES:
They supply somatic structures (skin and muscles).
10. AFFERENT NERVE:
These fibres bring information from the periphery to
the CNS. (or ) from one part of the CNS to another part.
(e. g. from the spinal cord to the brain). All afferent
nerves are sensory.
EFFERENT NERVE:
Carry commands to the organ supplied. (or) they carry
command from one part of the CNS to another part
(e.g. from brain to spinal cord). All efferent nerves are
motor.
11. GENERAL:
Refers to stimuli conducted throughout the entire
body, common to both cranial and spinal
nerves.Eg: touch, pressure, vibration, pain,
thermal sensation and proprioception .
SPECIAL:
Afferent information is encoded by highly
specialized sense organs and transmitted to the
brain in certain cranial nerves (I, II, VII, VIII, IX)
Ex; olfaction, vision, taste, hearing and vestibular
function.
13. Classification
Sensory cranial nerves
I. Olfactory
II. Optic
VII. Vestibulocochlear
Motor cranial nerves
III. Occluomotor
IV. Trochlear
VI. Abducent
XI. Accessory
XII. Hypoglossal
Mixed cranial nerves
V. Trigeminal
VII. Facial
IX. Glossopharyngeal
X. Vagus
14.
15. TRIGEMINAL NERVE
It is the fifth (V) cranial nerve
The largest cranial nerve
It is a mixed nerve, contains both
sensory & motor fibres.
It is attached to the ventral
surface of the pons, near its
upper border, by a large sensory
and a small motor, root---the
latter being placed medial and
anterior to the former.
16. Sensory and motor root
of the trigeminal nerve
The two roots then enter the middle cranial
fossa.
18. Sensory root of trigeminal nerve
The fibres of this root arise from the semilunar (gasserian)
ganglion.
They enter the brain stem through the side of pons.
Semilunar ganglion:
neural crest
Unipolar neurons
Crescent shaped
Meckel’s cavity
Peripheral & central
processes
20. Motor root of trigeminal nerve
consists of fibres that arise in the motor nucleus located
in upper pons
Pons – medial side of semilunar ganglion – foramen
ovale – to join mandibular division immediately below
the base of the skull.
Motor supply to the muscles of mastication– masticator
nerve.
21. Nuclei of the trigeminal nerve
Sensory nuclei
Mesencephalic
Primary sensory
Spinal
Motor nucleus
22. Mesencephalic nucleus
•Consists of afferent fibres that accompany the fibres
of the motor root.
•Entering the pons from the peripheral distribution of
the of the mandibular division of the trigeminal
nerve,these fibres ascend to the mesencephalic
nucleus of the trigeminal nerve.
•This nucleus serves as an afferent station that
receives proprioceptive impulses from the
temporomandibular joint,the periodontal
membrane,the maxillary and mandibular teeth, and
the hard palate.
•The mesencephalic nucleus also receives afferent
impulses from stretch receptors in the muscles of
23. Primary sensory nucleus
Lies in the upper part of the pons.
Lateral to the motor nucleus.
Mainly concerned in mediation of
poprioceptive impulses touch and
preassure(from the region to which the
trigeminal nerve is distributed).
24. Spinal (bulbospinal) nucleus:
• Caudal to the sensory nucleus.
• Forms ventral trigeminothalamic tract.
• Convey pain & temp from the entire
Trigeminal area.
25. Motor nucleus
Lies in the upper part of the pons in the
dorsal part.
It is situated mesial to the main sensory
nucleus
26. Functional components
General somatic affarent:
transmit exteroceptive impulses of touch pain and
thermal senses from the skin of the face and forehead,
mucous membranes of nasal cavities, oral cavity, nasal
sinuses, and floor of the mouth; the teeth; the anterior
two thirds of the tongue; and extensive portions of the
cranial dura.
27. Proprioceptive impulses (deep preassure and kinesthesis)
are conveyed from the teeth, periodontium, hard palate and
temporomandibular joint receptors.
The nerve also conveys afferent fibers from stretch receptors
in the muscles of mastication.
28. Special viceral efferent:
fibers innervate the muscles of
mastication, the tensor tympani and the
tenor veli palatini muscles, anterior belly of
digastric.
29. Divisions of the trigeminal nerve
Opthalmic V1
Maxillary V2
Mandibular V3
30. Opthalmic division V1
First division of the trigeminal nerve
Smallest of the three branches
Its fibres are sensory,or afferent, from the scalp, the
skin of the forehead, the upper eyelid lining the frontal
sinus, the conjunctiva of the eyeball, the lacrimal gland,
and the skin of the lateral angle of the eye. It also
transmits sensory impulses from the sclera of the eye
ball & the lining of the ethmoid cells.
Leaves ant. medial part of ganglion – cavernous sinus –
superior orbital fissure – orbit
In the middle cranial fossa
nervus tentori – dura
communication br.
Occlumotor
Trochlear
Abducent
33. Lacrimal nerve
Smallest of the three branches
It passes in to the orbit at the lateral angle
of the superior orbital fissure.
Then courses in an anterolateral direction
to reach the lacrimal gland.
Structures supplied
Lacrimal gland
Sensory from the skin of upper eyelid &
Lateral part of Eyebrow region.
Sensory from the conjunctiva of the lateral part of upper eyelid
34. Frontal nerve
Largest of three branches.
Direct continuation of the ophthalmic division.
It enters the orbit by way of the superior orbital fissure.
At about the middle of the orbit the frontal nerve divides
in to two branches: supraorbital and supratrochlear
nerves.
Supraorbital nerve Supratrochlear nerve
Largest branch of frontal n. Smallest branch of frontal n.
Leave the orbit through supra
orbital foramen
Passes toward the medial
angle of the orbit
Sensory from the medial part
of the upper eyelid , the skin of
the forehead and scalp to the
vertex of the skull
Sensory from the medial part
of the upper eyelid and the
lower medial part of the
forehead
Sensory from the lining of the
frontal sinus
Sensory from the conjuctivae
of the upper eyelid
35. Supra-trochlear : Smaller
• Supplies: conjunctiva and skin of medial aspect
of upper eyelid.
Lower and mesial aspects of forehead.
Supra-orbital : Larger
• Supplies : Upper eyelid
• Skin of the forehead and scalp as far back as
lambdoid suture.
FRONTAL NERVE
Medial
branch,
supraorbital
nerve
Supratrochlear
nerve
Frontal nerve
Ophthalmic
nerve
Lateral branch,
supraorbital
nerve
36. Nasocilliary nerve
It enters the orbit through the superior orbital fissure.
Branches
In the orbit
In the nasal
cavity
On the face
In nasal cavity:
Supply mucous membrane lining the cavity.
Terminal branches on the face:
Sensory to skin of medial part of both eyelids,
lacrimal sac, lacrimal caruncle. Also skin over the
side of the bridge of the nose.
37. NASOCILLIARY NERVE
Enters orbit through Superior orbital fissure
Branches
Short ciliary nerves
: sensory fibres from
ciliary ganglion to
eyeball
Long ciliary nerves :
iris and cornea
Infratrochlear nerve :
skin of both
eyelids,adjoining sides
of nose,lacrimal sac
and caruncle
Posterior ethmoidal
nerve : ethmoidal and
sphenoidal sinuses
Anterior ethmoidal
nerve : medial and
lateral internal nasal
branches
Infratrochlear
nerve
Short ciliary
nerves
Posterior
ethmoidal
nerve
Anterior
ethmoidal
nerve
Nasociliary
nerves
38. In the orbit
1. Long root of ciliary ganglion
2. Long ciliary nerves
3. Posterior ethmoid nerve
sensory
no relay
eyeball
short ciliary nerves
Two to three
branches
Iris & cornea
Post ganglionic fibres
From sup. Cervical
ganglion. Posterior ethmoid
canal
Muc mem. Of
post.ethmoidal cells
Sphenoid sinus
39. 4. Anterior ethmoid nerve
Nasociliary – continues anteriorly in medial
of orbit
Supplies mucous membrane of anterior
ethmoid cells & frontal sinus.
In the upper part of nasal cavity it divides in
to two sets of anterior nasal branches
External nasal branches
Skin over the tip and ala of
the nose
Internal nasal branches
Divide in the upper
anterior part of the
nasal cavity
Medial/ septal
Sensory to muc mem
of that region
Lateral
Muc mem of ant ends– sup & middle
Nasal conchae
Ant lat nasal wall
40. Applied anatomy
Ciliary ganglion
It is topographically related to this nerve but
functionally to oculomotor .
Autonomic ganglia
In case of injury to opthalmic nerve, there is
loss of “ corneal blink reflex”
41. Maxillary nerve V2
The maxillary nerve is entirely sensory in function.
Trigeminal
ganglion
Lateral wall of
cavernous sinus
Leaves skull
through foramen
rotundum
Pterygo-palatine
fossa
Inferior orbital
fissure
Orbital cavity
Infra orbital
foramen
42. Branches
Branches
given off in
the middle
cranial fossa
Branches in
the
pterygopalatin
e fossa
Branches in
the
infraorbital
groove and
canal
Terminal
branches on
the face
43. Branches of the maxillary
division
Middle cranial fossa
Middle meningeal nerve
Pterygo-palatine fossa
1. Zygomatic nerve
zygomaticotemporal
zygomaticofacial
2. Pterygo-palatine nerves
orbital
nasal
a. posterior superior lateral nasal branches
b. nasopalatine
palatine greater palatine
middle palatine
posterior palatine
pharyngeal
3. Posterior superior alveolar
GREATER
PALATINE
POSTERIO
R
PALATINE
NASOPALATINE
44.
45. Infraorbital canal
Middle superior alveolar
Anterior superior alveolar
Face
Inferior palbebral
External nasal
Superior labial
1 PSA branches
2 Infra orbital n.
3 Maxillary nerve
4 Foramen rotundum
5 Greater palatine
6 Nasopalatine
46. Applied anatomy
Sphenopalatine ganglion
It is topographically related to this nerve but
functionally to facial nerve .
It is the largest peripheral parasympathetic
ganglion
Autonomic ganglia
In case of injury to opthalmic nerve, there is
loss of “ sneeze reflex”
47. Mandibular division V3
Largest of the three divisions of the Vth
nerve.
Formed by union of large sensory &
small motor bundle of fibers.
Sensory fibers arise from semilunar
ganglion.
Motor fibers derived from motor cells
located in the medulla oblongata.
48. Course of the mandibular
nerve
Sensory root :
Trigeminal ganglion
Motor root :
Medulla oblongata
Exit cranium
through foramen
ovale
Unite to form the
main trunk
After 2-3 mm
divides to form
Anterior and
Posterior divisions
50. Branches from main trunk
a) nervous spinosus: arises
outside the skull – passes into
middle cranial fossa to supply
dura & mastoid cells
b) nerve to internal
Pterygoid muscle: motor
Internal pterygoid
tensor veli palatini
tensor tympani
51. Branches from the anterior trunk
Anterior trunk supplies (sensory & motor)
skin & mucous membrane of the cheek,
buccal gingivae &lower molars.It passes
downward & forward where it divides:
1.Branch to external pterygoid muscle
2.Branch to masseter muscle
3.Branches to temporal muscles
a. Anterior deep temporal nerve
b. Posterior deep temporal nerve
4.Buccal (long buccal) nerve
52. Branches from the posterior
trunkmainly sensory with some motor components
1.Auriculotemporal
2.Lingual
3.Inferior alveolar
53.
54. Auriculotemporal nerve
Arises by a medial & lateral root.
The roots embrace the middle
meningeal artery & unite just below
the foramen spinosum
Deep to Lateral pterygoid– between
sphenomandibular ligament & neck
of condyle.
Crosses zyg arch upwards and
divides
Branches:
i. Parotid: sensory, secretory,
vasomotor .
ii. Articular: post TMJ
iii. Auricular: skin of helix & tragus
iv. Meatal : skin lining meatus &
tympanic membrane
v. Terminal: scalp over temporal
region
55. Communications of auricotemporal nerve:
1. Two roots of the nerve ,each root receives
communicating fibers from the otic ganglion.
These fibers are postganglionic parasympathetic
secretory fibers that have come from the
glossopharyngeal nerve by way of lesser
superficial petrosal nerve. They control the
secretion of the parotid gland.
2. Communicating branches of postganglionic
sympathetic fibres – vasomotor to parotid.
3. Communicating branches to facial – purely
sensory.
56. Lingual nerve
- Medial to Lateral
Pterygoid muscle –
descends – lies
between medial
pterygoid & ramus
of mandible in
pterygo mand space.
- Contributes sensory
fibers to the mucous
membrane of the floor
of mouth & gingiva on
lingual surface of
mandible. Also to
bicuspids & 1st
molars.
57. Communications of
the lingual nerve:
As the lingual nerve
passes medial to the
lateral pterygoid
muscle it is joined by
corda tympani nerve,
which conveys
secretory fibres from
the facial nerve.
These
parasympathetic
fibers control the
submandibular &
58. Inferior alveolar nerve
largest of the branches of the
post div of mandibular nerve.
Medial to ramus, in the
pterygomandibular space, it
enters the mand. Foramen
It is distributed throughout the
body of mandible
In the canal – apical fibres to
dental pulp, also to periodontal
membrane.
At the mental foramen – mental
nerve, incisive nerve
59. At mental foramen, div into 2 branches
Mental nerve : leaves the mental foramen, supplies skin
of the chin, lower lip & mm of lower lip. sensory
Incisive nerve: fine incisive plexus to supply cuspids &
incisors
Before entering mandibular foramen, gives off
mylohyoid branch
Dwn & frwd in
mylohyoid groove.
Motor fibres: mylohyoid,
ant belly of digastric.
Sensory:mandibular
incisors
60. Autonomic ganglia associated
with mandibular branch
Submandibular ganglion: peripheral
parasympathetic ganglion.
Topographically related to lingual
nerve, but functionally related to corda
tympani branch of facial.
Otic ganglion: peripheral
parasympathetic ganglion.
Topographically intimately related to
mandibular nerve, but functionally to
glossopharyngeal nerve.
61. Applied anatomy
Trigeminal neuralgia/Tic Douloureux
characterised by extremely severe lancinating
pain that occurs in paroxysms, limited to one or
more branches of Trigeminal n.
Etiology:
Idiopathic Vascular compression
Progressive degeneration
Intra-cranial tumor
Peripheral nerve injury
62. Clinical features:
- Older adults, Female predilection
- Right side affected more
- Intense shooting stabbing pain
- Electric shock-like
- Unilateral
- Maxillary > Mandibular > Ophthalmic
- Trigger zone
63. Treatment of trigemial
neuralgia
Carbamazepine – 100mg thrice daily, titrated over 1-5
weeks till remission.
1.Peripheral nerve- a. cryosurgery
b. peripheral neurotomy
2.Gasserian ganglion- a.Thermocoagulation
b. Glycerol injection
3.Brain stem- Microvascular decompression of nerve root
64. Frey’s syndrome:
damage to auriculotemporal nerve & subsequent
reinnervation of sweat glands.
C/F: Flushing & sweating on the invovled side of the face
Treatment: severing the nerve
Sensory distribution of trigeminal nerve explains why
headache is a common symptom in invovlement of
- the nose (common cold, boils )
- the PNS ( sinusitis )
-teeth & gums ( infections & inflamns )
-eyes ( refractive errors, glaucoma )
-meninges (meningitis )
65. Posterior superior alveolar nerve
block
Complication
s-
Hematoma
This is
produced
by inserting
the needle
far too
posteriorly
in to the
pterygoid
plexus of
veins
1 maxillary nerve
2 posterior superior alveolar branches
69. CONTENTS
Introduction.
Organization of Nervous System.
Related Terminologies.
Cranial Nerves.
Detailed study of
V. Trigeminal nerve
VII. Facial nerve
IX. Glossopharyngeal nerve
X. Vagus nerve
XII. Hypoglossal nerve
References.
70.
71. FACIAL NERVE
It is the seventh cranial nerve (VII)
It is the nerve of the second branchial
arch
It is both motor and sensory
72. Nuclei of the facial nerve
Motor nucleus
Superior
salivatory
nucleus
Lacrimatory
nucleus
Nucleus of
tractus
solitarius
73.
74. Central connections
Motor nucleus
Upper part of face :
Cortico-nuclear fibres
from motor cortex of
both sides.
Lower part of face:
Cortico-nuclear fibres
from opposite
cerebral hemisphere.
75. Functional components
Special visceral efferent
muscles of 2nd branchial
arch
General visceral efferent
secretomotor
Special visceral afferent
taste sensation from
anterior 2/3rd of tongue
and palate
General somatic afferent
part of skin of the ear
76. Course
The course of the facial nerve can be
divided in to
Intracranial
Extracranial
84. Infranuclear paralysis
Lesion 1outside the
stylomastoid foramen
Lesion 2 in the facial
canal and involving the
corda tympani nerve
Lesion 3 higher in the
facial canal and involving
the stapedius muscle
Lesion 4 involving the
geniculate ganglion
Lesion 5 in the internal
auditory meatus
Lesion 6 at the
emergence of facial nerve
85. Bell’s Palsy
Definition: Bell’s palsy is defined as an idiopathic
paresis or paralysis of the facial nerve of sudden
onset(unilateral lower motor neuron paralysis of
sudden onset, not related to any other disease
elsewhere in the body).
Etiology
Symptoms
86. Treatment
Physiotherapy
Steroids - prednisolone 1mg/kg body
wt for 10-14 days with a gradual
tapering
Proper care of the eye
Antivirals
Chronic sequeale Hyperkinesia
Hypokinesia
87.
88. GLOSSOPHARYNGEAL
NERVE
IX Cranial nerve
Mixed
Nerve of third branchial arch
Ganglia
• Detached part of inferior
• No branchesSuperior
• Larger
Inferior
89. Nuclei of the Glossopharyngeal
nerve
Nucleus
ambiguus
Inferior
salivatory
nucleus
Nucleus of
tractus
solitarius
93. Course - Extracranial
Internal jugular vein and
Internal carotid artery
Internal and External
carotid arteries
Side of the pharynx
Submandibular region
Lingual
Branches
Tonsillar
Branches
102. Applied Anatomy
1. Clinical testing
2. Paralysis of the vagus nerve
3. Irritation of the auricular branch of the vagus
4. Stimulation of the auricular branch
5. Irritation of the recurrent laryngeal nerve
6. Communication with facial nerve
103.
104. Hypoglossal Nerve
XII cranial nerve
Motor
Supplies all muscles of the tongue,
except palatoglossus muscle
106. 10- 15 rootlets through medulla oblongata
Two bundles
Pierce dura mater
Lower part of the canal – single nerve trunk
Hypoglossal canal
Between internal jugular
vein and internal carotid artery
It decends between internal
jugular vein & internal carotid artery in
front of the vagus deep to the parotid gland ,the
styloid process, post. belly of diagastric,stylohyoid, and
posterior auricular & occipital arteries
Course
107. At the lower border of
post. Belly of diagastric it
curves forwards, hooks round
the lower sternomastoid branch
Of occipital artery crosses IC &
EC arteries & the loop of the
lingual artery & enters
submandibular region
Rests on hyoglossus muscle
Deep to mylohyiod muscle
Pierces genioglossus
Substance of the tongue
109. Applied Anatomy
Clinical testing---by asking the patient
to protrude his tongue.
Lesion produces paralysis of the
tongue of that side.
Inranuclear lesion – gradual atrophy of
paralyzed half of the tongue.
Supranuclear lesion – paralysis
without wasting.
110. A clinicians complete knowledge of the
anatomy of the cranial nerves and its
applied aspect is necessary for
providing treatment and preventing
complications in routine clinical
practice.
111. References
1) Human anatomy BD Chaurasia. Vol 3, 3rd edition.
2) Grays anatomy 39th edition.
3) Handbook Of Local Anaesthesia, Malamed 5th edition.
4) Burkets Oral medicine-10th edition.
5) Lee Mc Gregor’s synopsis of surgical anatomy 12th edition.
6) Monheim’s local anesthesia & pain control in dental practice.7th edition.
7) Human physiology Chatterjee 10th edition.
8) Correlative neuroanatomy and functional neurology Chusid 16th edition.
9) Stedmans medical dictionary 21st edition.
10) Textbook of OMFS Neelima Malik 1st edition.
11) Textbook of human neuroanatomy Inderbir Sing 6th edition.
12) Cranial nerves functional anatomy Stanley Monkhouse.
13) Electronic media.