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© Medisafe| Proprietary& Confidential
© Medisafe | Proprietary & Confidential 2
To empower people to improve
their health using technology
WHY MEDISAFE
© Medisafe | Proprietary & Confidential 2
PLAYVIDEO
MEETMAKEBA
When Makeba’s son was rushed to
the ER, doctors raced to find the
problem. Diagnosis: Crohn’s Disease.
Here’s how this busy mother of 4
stays on top of it all with help from
Medisafe.
Medisafe is a leading digital
therapeutics company specializing
in digital drug companions
WHO WE ARE
© Medisafe | Proprietary & Confidential 3
Medisafe’s Patient Engagement Platform
Industry Leader
Proven Solution
Meeting patients in their moments that matter.
Leading Platform
registered users
worldwide
8M
DAU/MAU ratio
10-30% higher than
68%
Medications managed
by average user
6+
Holistic Approach
Adherence Lift
15-20%
Persistence Lift
Over 52-week period
15%
20+ Brands across
Pharma partners
© Medisafe | Proprietary & Confidential
Medisafe’s Patient Engagement Platform
© Medisafe| Proprietary& Confidential 5
Impact through the following use cases:
Methodology:
Model designed by Sage Growth Partners and leverages proven data
points from validated pharma case studies, IQVIA studies (Match and
pre/post), and RCT studies. In addition to secondary research published
on NIH’s National Library of Medicine.
ImproveFirst
Fill Rate
Improved
Adherence
Extensionof
Persistence
Care
Coordination
Efficiency
Expanded
Referrals
ImprovedClinical
Outcomes
Real World Evidence: Economic Impact for Pharma
© Medisafe | Proprietary & Confidential
A national hub partner implemented a Medisafe program for all
nurses, utilizing digital engagement for patient support.
The result?
Real World Evidence: Connecting Pharma to patients
6
Patients are staying
engaged, for longer.
Nurses have more time for at-
risk patients, and connect
successfully.
► 7,255 patients enrolled
► 41%rate of enrollment
► 21avg. patients per nurse
► 71NPS score
74%
patients on program for 120
days are still active
72%
rate of contact (up
from 45% before
launch)
4,695 hrs.
saved from tasks
completed by Medisafe
(over 4 mo.)
© Medisafe | Proprietary & Confidential
Case Study: Supporting Patients through Digital Platform
Validated by Komodo Health
Care Coordination
Efficiencies
Increase in connectivity;
outbound calls to patients
60%
Engagement: patients
active in program +120 days
74%
Integrated Hub program results
Adherence and
Persistence
MPR of program
Users; increase of
7% from baseline
96%
Persistence improvement
over 52-week period
15%
3rd party claims data validation
Access and
Coordination
Increase of
‘first fill’ rate
5%
Patient acceptance
rate in integrated
Hub support program
41%
Biologic digital program results
© Medisafe | Proprietary & Confidential
Drowsiness
Depression
Dizzines
s
Anxiety
Pain
Headache
Abdominal
pain
Nausea
© Medisafe | Proprietary & Confidential
Patient Insights
Survey to 4k patients on health trends, COVID-19
● 85% of patients are fully vaccinated - compared to 6% in Jan.
● 80% will get a booster shot - compared to 57% who planned to get a vaccine in Jan,
20% in 2020.
● 28% have a more favorable opinion of pharma companies due to vaccine efforts - up
5% from Jan., up 11% from 2020
○ 13% prefer the Pfizer vaccine over all others
● 47% say fear of hospitalization is lead them to pay more attention to medication use
● 51% credit public health experts for driving vaccines
● Black communities cite higher vaccination rates at 95%
● Men have a higher confidence in vaccines at 88%
● Women are taking their medications more regularly at 53%
© Medisafe| Proprietary& Confidential

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Medisafe_What's Next in RWE_mHealth Israel

  • 2. © Medisafe | Proprietary & Confidential 2 To empower people to improve their health using technology WHY MEDISAFE © Medisafe | Proprietary & Confidential 2 PLAYVIDEO MEETMAKEBA When Makeba’s son was rushed to the ER, doctors raced to find the problem. Diagnosis: Crohn’s Disease. Here’s how this busy mother of 4 stays on top of it all with help from Medisafe. Medisafe is a leading digital therapeutics company specializing in digital drug companions WHO WE ARE
  • 3. © Medisafe | Proprietary & Confidential 3 Medisafe’s Patient Engagement Platform Industry Leader Proven Solution Meeting patients in their moments that matter. Leading Platform registered users worldwide 8M DAU/MAU ratio 10-30% higher than 68% Medications managed by average user 6+ Holistic Approach Adherence Lift 15-20% Persistence Lift Over 52-week period 15% 20+ Brands across Pharma partners
  • 4. © Medisafe | Proprietary & Confidential Medisafe’s Patient Engagement Platform
  • 5. © Medisafe| Proprietary& Confidential 5 Impact through the following use cases: Methodology: Model designed by Sage Growth Partners and leverages proven data points from validated pharma case studies, IQVIA studies (Match and pre/post), and RCT studies. In addition to secondary research published on NIH’s National Library of Medicine. ImproveFirst Fill Rate Improved Adherence Extensionof Persistence Care Coordination Efficiency Expanded Referrals ImprovedClinical Outcomes Real World Evidence: Economic Impact for Pharma
  • 6. © Medisafe | Proprietary & Confidential A national hub partner implemented a Medisafe program for all nurses, utilizing digital engagement for patient support. The result? Real World Evidence: Connecting Pharma to patients 6 Patients are staying engaged, for longer. Nurses have more time for at- risk patients, and connect successfully. ► 7,255 patients enrolled ► 41%rate of enrollment ► 21avg. patients per nurse ► 71NPS score 74% patients on program for 120 days are still active 72% rate of contact (up from 45% before launch) 4,695 hrs. saved from tasks completed by Medisafe (over 4 mo.)
  • 7. © Medisafe | Proprietary & Confidential Case Study: Supporting Patients through Digital Platform Validated by Komodo Health Care Coordination Efficiencies Increase in connectivity; outbound calls to patients 60% Engagement: patients active in program +120 days 74% Integrated Hub program results Adherence and Persistence MPR of program Users; increase of 7% from baseline 96% Persistence improvement over 52-week period 15% 3rd party claims data validation Access and Coordination Increase of ‘first fill’ rate 5% Patient acceptance rate in integrated Hub support program 41% Biologic digital program results
  • 8. © Medisafe | Proprietary & Confidential Drowsiness Depression Dizzines s Anxiety Pain Headache Abdominal pain Nausea
  • 9. © Medisafe | Proprietary & Confidential Patient Insights Survey to 4k patients on health trends, COVID-19 ● 85% of patients are fully vaccinated - compared to 6% in Jan. ● 80% will get a booster shot - compared to 57% who planned to get a vaccine in Jan, 20% in 2020. ● 28% have a more favorable opinion of pharma companies due to vaccine efforts - up 5% from Jan., up 11% from 2020 ○ 13% prefer the Pfizer vaccine over all others ● 47% say fear of hospitalization is lead them to pay more attention to medication use ● 51% credit public health experts for driving vaccines ● Black communities cite higher vaccination rates at 95% ● Men have a higher confidence in vaccines at 88% ● Women are taking their medications more regularly at 53%

Hinweis der Redaktion

  1. At Medisafe it is our mission to empower people to improve their health using technology. A mission a decade stronger as we’ve been supporting patients in their daily lives since our company was founded in 2012. Our digital solutions have a Real Impact for Real patients (like Makeba and her son, 2 real Medisafe users). Our success in making medication management a part of daily life, has made us a leading digital therapeutics company specializing in digital drug companions. We create solutions that put hyper-personalized, and holistic, support in the palms of patients’ hands.
  2. We accomplish this type of support with our interoperable platform. Let me tell you a bit more about Medisafe’s Next-Gen digital platform Medisafe currently has 8 million registered users, worldwide, who rely on us to manage all their medications. This includes patient and caregivers who have found us on their own, and program users, who are enrolled in branded digital patient support. <CLICK> Of our monthly active users, 68% of them are use Medisafe daily. We see more engagement among users with their daily medication management than popular social media platforms such as Facebook, twitter or Instagram. <CLICK> We take a holistic approach to medication management to create empowerment and engagement. The average Medisafe user is managing six or more medications. We put proactive and positive support in their hands. <CLICK> We take this a step further with our pharma partners . Our proven digital solutions show an average adherence lift of 15—20% over existing patient support resources and programs.
  3. We make all of this patient engagement possible with Medisafe’s digital drug companions. Our advanced platform helps patients navigate their treatment journeys through personalized, timely support, keeping them digitally connected throughout the treatment journey. Our innovations and technologies together leverage a keen understanding of the patient mindset and predict how intervene to reach treatment goals. Medisafe’s JITI™ technology increases patient engagement, improves medication adherence and extends treatment retention through predictive AI delivering personalized patient support at precise moments in each patient journey. It is an AI engine fueled by therapeutic elements, patient support, and patient elements. Medisafe’s Care Integration Engine incorporates data from digital companions into existing patient support models. This scalable innovation can be seamlessly folded into existing solutions and deployed as part of the Care Connector solution to offer patient support teams insights into daily patient behaviors. Medisafe Maestro is our advance technology that activates optimal digital patient journeys with personalized timely support. Medisafe Maestro designs, deploys and manages digital drug companions to support patients on specific treatment, and enables scalable solutions. Through an advanced digital platform, we’re able to bring the digital patient journey to life and incorporate existing solutions and services seamlessly in a personalized digital experience.
  4. As we look at Real-World Evidence of the use of digital drug companions, many of questions we get from our pharma partners is: what’s the value of these programs? To answer this question we worked with Sage Growth Partners, Healthcare Research consultants, to create an Economic Impact Model to demonstrate value delivered to pharmaco through Medisafe platform. Below is the analysis modeled for a biologic which identifies potential value capture over the next two years.   Model focuses on impact through following use cases: Improve First Fill Rate (increase in the number of patients “taking” first dose/injection with Medisafe through improved onboarding processes) Improved Adherence (increasing the percentage of compliant patients to their scheduled injections) Extension of Persistence (extending the duration of compliant patients on therapy) Care Coordination Efficiency (adding digital channel to patient support improves quality of support and improves productivity of clinicians (connection rate, time spent on critical activities)) Expanded Referrals Improved Clinical Outcomes   Each of these use cases is a lever to deliver value by comparing existing practices without Medisafe to value delivered through Medisafe platform.
  5. As we look at Real-World Evidence of the use of digital drug companions, another important area of focus in on connecting pharma to patients. In 2020 an established Pharma Hub, seeking to augment their existing patient support model, partnered with Medisafe to provide nurses with a digital patient engagement platform. By incorporating Medisafe’s digital solutions into the nurse and patient support tools both the Hub and the Pharma Brand experienced immediate and impressive program results. Patient support nurses incorporated the Care Connector and digital drug companion into patient onboarding calls. Nurses offered patients a digital tool to manage all of their medications and help them stay connected to a clinical support team. <CLICK> Hub nurses easily adapted existing patient support workflow to incorporate onboarding patients into the Medisafe platform, with great success. Of the patients offered digital support 45% enrolled in the program. <CLICK> Patients weren’t the only ones to benefit from Medisafe digital solutions. Incorporating the Care Connector into their workflow, nurses gained great efficiency, and increased bandwidth to directly support the patients whose care they manage. Comparing digitally aided patient support to control group shows increased efficiency through every phase of the patient journey. <CLICK>
  6. Real World Evidence isn’t just about providing value to pharma, but also about improving the lives of patients. To prove that digital drug companions improve patient lives, Medisafe commissioned Komodo Health, healthcare data and analytics firm, to conduct study on a biologic digital drug companion program to validate outcomes through Rx claims. Adherence and Persistence:  Komodo Health conducted two sets of analysis comparing Medisafe users in the biologic digital drug companion program to a matching control set based off demographic, relevant diagnosis (Dx) and treatment (Rx) criteria.  The only difference between the Medisafe test group and control group is the use of the digital drug companion.  In the analysis, the Medisafe test group improved adherence by 6-7% and extended refills by 5.25 weeks (15%). Access and Coordination: Results from one digital program around access and coordination showed significant impact on Access and Coordination. This case study includes a Medisafe designed and integrated program that provides transparency to patients through prior auth period to first injection support.  Not only did first fill increase by 5% but overall therapy compliance and extension on therapy improved delivering a two-year value to pharmaco close to $30M. Care Coordination Efficiencies: This case study focuses on a integrated program in which patient support incorporated Medisafe’s digital solutions to manage all of their medications and help them stay connected to their support team.
  7. To better understand the true impact on patients, we also capture feedback directly from patients on how patients are managing their health and using digital tools to manage their lives. Medisafe routinely surveys its patient population on current health issues, and can track changes in perceptions over time. This provides real-world insights into the lives of patients and what issues may be impacting their health. For example, in our most recent survey regarding current COVID-19 issues, we found: A majority of patients have become vaccinated compared to just the 6% who intended to receive the vaccine in Jan. A majority of patients intend to get a booster shot compared to the 20% who ever intended to get the vaccine Vaccine efforts have helped to improve patients’ perception of pharma companies - improved 11% in just one year We also find nuances in patient surveys that show variances in attitudes among men, women, and communities of color and ethnicity These insights help to create a communication loop with patients, and obtain valuable information to help tailor support messages and provide guidance throughout the treatment journey.
  8. But perhaps the best way to capture real-world feedback from patients is to take their word for it. Medisafe is available to both Android and iOS smartphone users, and we maintain a 4.7 out of 5 star rating. More than 400,000 user reviews show that more patients turn to Medisafe to help manage their medications and support their treatment journey. This real-world evidence shows that patients want a convenient, simple, and personalized approach to their medication journey, and Medisafe is meeting that need.