OpioidAnalgesics2008

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jamal53

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History of Morphine in the U.S . ,[object Object],[object Object],[object Object],[object Object]

History of Morphine Use in the U.S. ,[object Object],[object Object],[object Object],[object Object]

How Does Morphine Work? ,[object Object],[object Object],[object Object]

Side effects of morphine ,[object Object],[object Object],[object Object]

‘Tinkering’ with the structure of morphine produced heroin

Heroin ,[object Object],[object Object],[object Object],[object Object]

Heroin is addictive because it crosses the BBB more quickly than morphine.

Heroin Addiction ,[object Object],[object Object],[object Object],[object Object]

How do these drugs work? ,[object Object]

Codeine is demethylated back to morphine in the liver ,[object Object],[object Object]

Codeine ,[object Object],[object Object],[object Object]

The C3 hydroxyl group is necessary for activity. (The methyl ether is only 0.1% as active)

Codeine is a useful cough suppressant ,[object Object]

‘Tinkering’ with the morphine structure can produce useful painkillers

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