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BIOMATERIALS IN ORTHOPAEDICS
MODERATOR
DR.Jishnu Prakash Baruah
PRESENTER
Dr.S.V.Harikrishnan(PGT 1st yr)
LEARNING OBJECTIVES
• Basic concepts and definitions
• Common orthopaedic biomaterials and clinical
applications
• General tissue implant responses
• Complication associated with biomaterials
• Recent advances
INTRODUCTION
A biomaterial is
• substance / combination of substances (other
than a drug)
• Origin: synthetic / natural
• life span : not specified
• Augments / replaces any tissue, organ or
function of the body
Bone plate in 1900,earliest
successful biomedical implants
Artificial knee joint to alleviate
pain and restore functions
BIOMATERIALS CLASSIFICATION
I
• First generation
• Bioinert materials
II
• Second generation
• Bio active and biodegradable materials
III
• Third generation
• Materials designed to stimulate specific responses at
molecular level
FIRST GENERATION
• Invented in 1980
• AIM :
 Same physical properties to match replaced
tissue
Minimal toxic response to host
Bio inert – minimum immune response and
foreign body reaction
SECOND GENERATION
• Invented between 1980 and 2000
• AIM
Interact with biological environment
Enhance biological response and tissue surface
bonding (BIO ACTIVE)
Undergo progressive degradation with healing and
regeneration of tissues (BIODEGRADABLE)
THIRD GENERATION
• Invented in 2002(Hench and polak)
• AIM
To stimulate specific cellular response at
molecular level
Signal and stimulate specific cellular activity
BIOMATERIALS USED IN ORTHOPAEDICS
• Metal and metal alloys
• Ceramics and ceramometallic materials
• Tissue adhesives
• Bone replacement materials
• Carbon materials and composites, polymers
BASIC CONCEPTS & DEFINITIONS
• Force applied will lead to deformation and if
continued beyond a certain point will lead to
ultimate failure
• The force per unit area----- STRESS and
Deformation is known as STRAIN
STRESS-STRAIN CURVE
YOUNG’S MODULUS OF ELASTICITY
Young’s modulus of elasticity
DEFINITIONS
• TENSILE STRENGTH/ ULTIMATE TENSILE STRENGTH –
The maximum stress on the curve before breakage
• YIELD STRESS-
Point at which elastic behaviour changes to plastic Behaviour
• BREAKING STRESS
Point at which the substance fails/brakes
• FATIGUE FAILURE: The failure of a material with repetitive
loading at stress levels below the ultimate tensile strength
YIELD STRESS
ULTIMATE STRESS
BREAKING STRESS
S
T
R
E
S
S
STRAIN
PLASTICELASTIC
DEFINITIONS
• STRENGTH: The degree of resistance to deformation of a
material
- Strong if it has a high tensile strength
• TOUGHNESS: Amount of energy per unit volume that a
material can absorb before failure
• DUCTILITY/ BRITTLENESS- The amount by which a material
deforms (i.e. the strain that occurs) before it breaks.
• HOOKE’S LAW → Stress α Strain produced
- The material behaves like a spring
BONE BIOMECHANICS
Anisotropic:
elastic modulus depends on direction of loading
 weakest in shear> tension> compression
 viscoelastic:
 stress-strain characteristics depend on the rate of
loading
WOLF’S LAW:
Bone remodelling occurs along the line of stress
 Bone density changes with age, disease, use and disuse
Biomaterials in orthopaedics ppt
CLINICAL APPLICATIONS OF
ORTHOPAEDIC IMPLANTS
• Osteosynthesis
• Joint replacements
• Nonconventional modular tumor implants
• Spine implants
IDEAL IMPLANT MATERIAL
• Chemically inert
• Non-toxic to the body
• Great strength
• High fatigue resistance
• Low Elastic Modulus
• Absolutely corrosion-proof
• Good wear resistance
• Inexpensive
COMMON IMPLANT MATERIALS IN
ORTHOPAEDICS
Metal Alloys:
 stainless steel
Titanium alloys
Cobalt chrome alloys
Nonmetals:
 Ceramics & Bioactive glasses
 Polymers (Bone cement, polyethylene)
STAINLESS STEEL
COMPOSITION:
Iron (62.97%)
Chromium (18%)
 Nickel (16%)
Molybdenum (3%)
Carbon (0.03%)
• The form used commonly is 316L (3%
molybdenum, 16% nickel & L = Low carbon
content)
STAINLESS STEEL
ADVANTAGES
 Relatively ductile
 Biocompatible
 Relatively cheap
 Reasonable corrosion
resistance
 STRONG
• Used in plates, screws, IM
nails, external fixators
DISADVANTAGES:
 Poor wear resistance
 High Young’s modulus –
200 G Pascals (10 that of
bone)
 stress shielding of
surrounding bone and
bone resorption
COBALT CHROME ALLOYS
• Contains primarily cobalt
(30-60%)
• Chromium (20-30%) added
to improve corrosion
resistance
• Minor amounts of carbon,
nickel and molybdenum
added(ASTM F75 Vitallium)
COBALT CHROME ALLOYS
Advantages:
Excellent resistance to
corrosion
Excellent long-term
biocompatibility
Strength (very strong)
Disadvantages:
Very high Young’s
modulus
 Risk of stress
shielding
Expensive
USES
• Usually for bearing surfaces
• THR
• Metal-on-metal devices.
THR IMPLANT BEARING SURFACES
Metal-on-polyethylene Metal-on-metal
TITANIUM ALLOYS
• Contains:
- Titanium (89%)
- Aluminium (6%)
- Vanadium (4%)
- Others (1%)
• Most commonly
orthopaedic titanium
alloy is TITANIUM 64
(Ti-6Al-4v)
TITANIUM ALLOYS
• ADVANTAGES:
 Corrosion resistant
 Excellent biocompatibility
 Ductile
 Fatigue resistant
 Low Young’s modulus
 MR scan compatibly
 osseointegration
• Useful in Int fixators ,
plates, vertebral
spacers,IM nails etc.
 DISADANTAGES:
 poor wear characteristics
 Systemic toxicity – vanadium
 Relatively expensive
Biomaterials in orthopaedics ppt
YOUNG’S MODULUS AND DENSITY OF
COMMON BIOMATERIALS
MATERIAL YOUNG’S MODULUS (GPa) DENSITY (g/cm³)
Cancellous bone 0.5-1.5 -
UHMWPE 1.2 -
PMMA bone cement 2.2 -
Cortical bone 7-30 2.0
Titanium alloy 110 4.4
Stainless steel 190 8.0
Cobalt chrome 210 8.5
COMPARISON OF METAL ALLOYS
ALLOY Young’s modulus
(GPa)
Yield strength
(MPa)
Ultimate tensile
strength (MPa)
Stainless Steel 316L 190 500 750
Titanium 64 110 800 900
Cobalt chrome
F562
230 1000 1200
BIOACTIVE IMPLANTS
 Coating of implant with a bioactive ceramic
(HA and BGs).
electrophoretic deposition
plasma spraying,
radio frequency or ionic ray sputtering,
 laser ablation or hot isostatic pressure
All are not cost effective
HA COATED IMPLANTS
CERAMICS
• Compounds of metallic elements e.g
Aluminium bound ionically or covalently with
nonmetallic elements
• Common ceramics include:
- Alumina (aluminium oxide)
- Silica (silicon oxide)
- Zirconia (Zirconium oxide)
- Hydroxyapatite (HA)
CERAMICS
Ceramics are refractory polycrystalline
compounds
– Usually inorganic
– Highly inert
– Hard and brittle
– High compressive strength
– Generally good electric and thermal insulators
– Good aesthetic appearance
Biomaterials in orthopaedics ppt
Biomaterials in orthopaedics ppt
ALUMINA(INERT CERAMICS)
APPLICATIONS:
• femoral head
• bone screws and
plates
• porous coatings for
femoral stems
• porous spacers
(specifically in
revision surgery)
• knee prosthesis
ZIRCONIA(ZrO2 )
• Obtained from the
mineral zircon(Zr)
APPLICATION:
• femoral head
• artificial knee
• bone screws and plates
• favored over UHMWPE
due to superior wear
resistance
CERAMICS
ADVANTAGES
Chemically inert &
insoluble
Best biocompatibility
 Very strong
 Osteoconductive
Low wear resistance
DISADVANTAGES
 Brittleness
 Very difficult to process –
high melting point
 Very expensive
 High young’s modulus
 Low tensile strength
 Poor crack resistance
HA COATED SCREWS
BEARING SURFACES
Ceramic-on-polyethylene Ceramic-on-ceramic
BIOACTIVE CERAMICS
Bio glass–ceramics
 calcium phosphates
(CaPs)
Silicon incorporated
cements and ceramics
 Not used in high load
bearing devices due to
low tensile strength and
toughness
BIODEGRADABLE CERAMICS(CALCIUM
PHOSPHATE)
Uses
• repair material for bone
damaged trauma or disease
• void filling after resection of
bone tumours
• repair and fusion of vertebrae
• repair of herniated disks
• repair of maxillofacial and
dental defects
• drug-delivery
CALCIUM PHOSPHATE
POLYMERS
• Consists of many repeating units of a basic
sequence (monomer)
• Used extensively in orthopaedics
• Most commonly used are:
- Polymethylmethacrylate (PMMA, Bone
cement)
- Ultrahigh Molecular Weight Polyethylene
(UHMWPE)
Biomaterials in orthopaedics ppt
PMMA
The powder contains:
PMMA copolymer
Barium or Zirconium oxide (radio-opacifier)
Benzoyl peroxide (catalyst)
Clinically relevant stages of cement reaction:
DOUGH TIME – 2to 3 mins
WORKING TIME – 5 to 8 mins
SETTING TIME – 8 to 10 mins
PMMA (BONE CEMENT)
• Mainly used to fix prosthesis in place
can also be used as void fillers
• Available as liquid and powder
• The liquid contains:
The monomer N,N-dimethyltoluidine (the
accelerator)
 Hydroquinone (the inhibitor)
• Tough
• Ductile
• Resilient
• Resistant to wear
DISADVANTAGES
• Susceptible to
abrasion
• Wear usually caused
by third body
inclusions
• Thermoplastic (may
be altered by
extreme
temperatures)
• weaker than bone in
tension
ADVANTAGES
USES:
-It provides an excellent
primary fixation of the
prosthesis
Biomaterials in orthopaedics ppt
UHMWPE
• A polymer of ethylene with
MW of 2-6million
• Used for acetabular cups in
THR prostheses and tibial
components in TKR
• Metal on polyethylene has
high success rate in bearing
surface in THR
• Osteolysis produced due to
polyethylene wear debris
causes aseptic loosening
• Increases polymer chain cross-
linking which improves wear
characteristics
BIODEGRADABLE POLYMERS
• Polyglycolic acid, Polylactic
acid, copolymers
• As stiffness of polymer
decreases, stiffness of
callus increases
• Hardware removal not
necessary (reduces
morbidity and cost)
CARBON FIBRES
APPLICATIONS:
Total hip replacement
Internal fixation for various fractures
Spine surgeries
DISADVANTAGES:
Release of carbon debris in to surrounding
medium
Biomaterials in orthopaedics ppt
TISSUE ADHESIVES
PROPERTIES OF TISSUE ADHESIVES:
• Moderately viscous (spread easily)
• Ability to degrade at a appropriate rate
• Biocompability
Commonly used tissue adhesives are
- fibrin gel,albumim,cyanoacrylates and
mucopolysaccharides
GENERAL TISSUE-IMPLANT
RESPONSES
• All implant materials elicit some response from
the host
• The response occurs at tissue-implant interface
• Response depend on many factors;
- Type of tissue/organ;
- Mechanical load
- Amount of motion
- Composition of the implant
- Age of patient
TISSUE-IMPLANT RESPONSES
BIOMATERIAL
TOXIC
NON TOXIC
DEATH OF SURROUNDING TISSUES
BIO ACTIVE BIO INERT
FIBROUS
ENCAPSULATION
INTERFACIAL
BOND FORMATION
BIODEGRADABLE
DISSOLUTION OF
MATERIAL
COMPLICATIONS
• Aseptic Loosening:
- Caused by osteolysis from body’s reaction to
wear debris
• Stress Shielding:
- Implant prevents bone from being properly
loaded
• Corrosion:
- Reaction of the implant with its environment
resulting in its degradation to oxides/hydroxides
COMPLICATIONS
• Infection
• Metal hypersensitivity
• Manufacturing errors
• VARIOUS FACTORS CONTRIBUTE TO IMPLANT
FAILURE
Biomaterials in orthopaedics ppt
RECENT ADVANCES
• Aim is to use materials with mechanical
properties that match those of the bone
• Modifications to existing materials to
minimize harmful effects
- Ex; nickel-free metal alloys
• Possibility of use of anti-cytokine in the
prevention of osteolysis around implants
• Antibacterial implant
RECENT ADVANCES
• Porous tantalum is also being successfully
used clinically in several orthopaedic
applications.
– high volumetric porosity,
– low elastic modulus
– good frictional characteristics
• Ideal candidate for weight-bearing
applications such as total joint arthroplasty
CONCLUSION
• Adequate knowledge of implant materials is
an essential platform to making best choices
for the patient
• Promising and satisfying results from use of
existing implant materials
• Advances in biomedical engineering will go a
long way in helping the orthopedic surgeon
• The search is on…
BIBLIOGRAPHY
• CAMPBELLS OPERATIVE ORTHOPAEDICS 12th
edition
• KULKARNI textbook of othopaedics and
trauma 2nd edition
• http://www.ncbi.nlm.nih.gov/pmc/articles/P
MC2706047/#bib197
THANKING YOU

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Biomaterials in orthopaedics ppt

  • 1. BIOMATERIALS IN ORTHOPAEDICS MODERATOR DR.Jishnu Prakash Baruah PRESENTER Dr.S.V.Harikrishnan(PGT 1st yr)
  • 2. LEARNING OBJECTIVES • Basic concepts and definitions • Common orthopaedic biomaterials and clinical applications • General tissue implant responses • Complication associated with biomaterials • Recent advances
  • 3. INTRODUCTION A biomaterial is • substance / combination of substances (other than a drug) • Origin: synthetic / natural • life span : not specified • Augments / replaces any tissue, organ or function of the body
  • 4. Bone plate in 1900,earliest successful biomedical implants Artificial knee joint to alleviate pain and restore functions
  • 5. BIOMATERIALS CLASSIFICATION I • First generation • Bioinert materials II • Second generation • Bio active and biodegradable materials III • Third generation • Materials designed to stimulate specific responses at molecular level
  • 6. FIRST GENERATION • Invented in 1980 • AIM :  Same physical properties to match replaced tissue Minimal toxic response to host Bio inert – minimum immune response and foreign body reaction
  • 7. SECOND GENERATION • Invented between 1980 and 2000 • AIM Interact with biological environment Enhance biological response and tissue surface bonding (BIO ACTIVE) Undergo progressive degradation with healing and regeneration of tissues (BIODEGRADABLE)
  • 8. THIRD GENERATION • Invented in 2002(Hench and polak) • AIM To stimulate specific cellular response at molecular level Signal and stimulate specific cellular activity
  • 9. BIOMATERIALS USED IN ORTHOPAEDICS • Metal and metal alloys • Ceramics and ceramometallic materials • Tissue adhesives • Bone replacement materials • Carbon materials and composites, polymers
  • 10. BASIC CONCEPTS & DEFINITIONS • Force applied will lead to deformation and if continued beyond a certain point will lead to ultimate failure • The force per unit area----- STRESS and Deformation is known as STRAIN
  • 11. STRESS-STRAIN CURVE YOUNG’S MODULUS OF ELASTICITY Young’s modulus of elasticity
  • 12. DEFINITIONS • TENSILE STRENGTH/ ULTIMATE TENSILE STRENGTH – The maximum stress on the curve before breakage • YIELD STRESS- Point at which elastic behaviour changes to plastic Behaviour • BREAKING STRESS Point at which the substance fails/brakes • FATIGUE FAILURE: The failure of a material with repetitive loading at stress levels below the ultimate tensile strength
  • 13. YIELD STRESS ULTIMATE STRESS BREAKING STRESS S T R E S S STRAIN PLASTICELASTIC
  • 14. DEFINITIONS • STRENGTH: The degree of resistance to deformation of a material - Strong if it has a high tensile strength • TOUGHNESS: Amount of energy per unit volume that a material can absorb before failure • DUCTILITY/ BRITTLENESS- The amount by which a material deforms (i.e. the strain that occurs) before it breaks. • HOOKE’S LAW → Stress α Strain produced - The material behaves like a spring
  • 15. BONE BIOMECHANICS Anisotropic: elastic modulus depends on direction of loading  weakest in shear> tension> compression  viscoelastic:  stress-strain characteristics depend on the rate of loading WOLF’S LAW: Bone remodelling occurs along the line of stress  Bone density changes with age, disease, use and disuse
  • 17. CLINICAL APPLICATIONS OF ORTHOPAEDIC IMPLANTS • Osteosynthesis • Joint replacements • Nonconventional modular tumor implants • Spine implants
  • 18. IDEAL IMPLANT MATERIAL • Chemically inert • Non-toxic to the body • Great strength • High fatigue resistance • Low Elastic Modulus • Absolutely corrosion-proof • Good wear resistance • Inexpensive
  • 19. COMMON IMPLANT MATERIALS IN ORTHOPAEDICS Metal Alloys:  stainless steel Titanium alloys Cobalt chrome alloys Nonmetals:  Ceramics & Bioactive glasses  Polymers (Bone cement, polyethylene)
  • 20. STAINLESS STEEL COMPOSITION: Iron (62.97%) Chromium (18%)  Nickel (16%) Molybdenum (3%) Carbon (0.03%) • The form used commonly is 316L (3% molybdenum, 16% nickel & L = Low carbon content)
  • 21. STAINLESS STEEL ADVANTAGES  Relatively ductile  Biocompatible  Relatively cheap  Reasonable corrosion resistance  STRONG • Used in plates, screws, IM nails, external fixators DISADVANTAGES:  Poor wear resistance  High Young’s modulus – 200 G Pascals (10 that of bone)  stress shielding of surrounding bone and bone resorption
  • 22. COBALT CHROME ALLOYS • Contains primarily cobalt (30-60%) • Chromium (20-30%) added to improve corrosion resistance • Minor amounts of carbon, nickel and molybdenum added(ASTM F75 Vitallium)
  • 23. COBALT CHROME ALLOYS Advantages: Excellent resistance to corrosion Excellent long-term biocompatibility Strength (very strong) Disadvantages: Very high Young’s modulus  Risk of stress shielding Expensive
  • 24. USES • Usually for bearing surfaces • THR • Metal-on-metal devices.
  • 25. THR IMPLANT BEARING SURFACES Metal-on-polyethylene Metal-on-metal
  • 26. TITANIUM ALLOYS • Contains: - Titanium (89%) - Aluminium (6%) - Vanadium (4%) - Others (1%) • Most commonly orthopaedic titanium alloy is TITANIUM 64 (Ti-6Al-4v)
  • 27. TITANIUM ALLOYS • ADVANTAGES:  Corrosion resistant  Excellent biocompatibility  Ductile  Fatigue resistant  Low Young’s modulus  MR scan compatibly  osseointegration • Useful in Int fixators , plates, vertebral spacers,IM nails etc.  DISADANTAGES:  poor wear characteristics  Systemic toxicity – vanadium  Relatively expensive
  • 29. YOUNG’S MODULUS AND DENSITY OF COMMON BIOMATERIALS MATERIAL YOUNG’S MODULUS (GPa) DENSITY (g/cm³) Cancellous bone 0.5-1.5 - UHMWPE 1.2 - PMMA bone cement 2.2 - Cortical bone 7-30 2.0 Titanium alloy 110 4.4 Stainless steel 190 8.0 Cobalt chrome 210 8.5
  • 30. COMPARISON OF METAL ALLOYS ALLOY Young’s modulus (GPa) Yield strength (MPa) Ultimate tensile strength (MPa) Stainless Steel 316L 190 500 750 Titanium 64 110 800 900 Cobalt chrome F562 230 1000 1200
  • 31. BIOACTIVE IMPLANTS  Coating of implant with a bioactive ceramic (HA and BGs). electrophoretic deposition plasma spraying, radio frequency or ionic ray sputtering,  laser ablation or hot isostatic pressure All are not cost effective
  • 33. CERAMICS • Compounds of metallic elements e.g Aluminium bound ionically or covalently with nonmetallic elements • Common ceramics include: - Alumina (aluminium oxide) - Silica (silicon oxide) - Zirconia (Zirconium oxide) - Hydroxyapatite (HA)
  • 34. CERAMICS Ceramics are refractory polycrystalline compounds – Usually inorganic – Highly inert – Hard and brittle – High compressive strength – Generally good electric and thermal insulators – Good aesthetic appearance
  • 37. ALUMINA(INERT CERAMICS) APPLICATIONS: • femoral head • bone screws and plates • porous coatings for femoral stems • porous spacers (specifically in revision surgery) • knee prosthesis
  • 38. ZIRCONIA(ZrO2 ) • Obtained from the mineral zircon(Zr) APPLICATION: • femoral head • artificial knee • bone screws and plates • favored over UHMWPE due to superior wear resistance
  • 39. CERAMICS ADVANTAGES Chemically inert & insoluble Best biocompatibility  Very strong  Osteoconductive Low wear resistance DISADVANTAGES  Brittleness  Very difficult to process – high melting point  Very expensive  High young’s modulus  Low tensile strength  Poor crack resistance
  • 42. BIOACTIVE CERAMICS Bio glass–ceramics  calcium phosphates (CaPs) Silicon incorporated cements and ceramics  Not used in high load bearing devices due to low tensile strength and toughness
  • 43. BIODEGRADABLE CERAMICS(CALCIUM PHOSPHATE) Uses • repair material for bone damaged trauma or disease • void filling after resection of bone tumours • repair and fusion of vertebrae • repair of herniated disks • repair of maxillofacial and dental defects • drug-delivery
  • 45. POLYMERS • Consists of many repeating units of a basic sequence (monomer) • Used extensively in orthopaedics • Most commonly used are: - Polymethylmethacrylate (PMMA, Bone cement) - Ultrahigh Molecular Weight Polyethylene (UHMWPE)
  • 47. PMMA The powder contains: PMMA copolymer Barium or Zirconium oxide (radio-opacifier) Benzoyl peroxide (catalyst) Clinically relevant stages of cement reaction: DOUGH TIME – 2to 3 mins WORKING TIME – 5 to 8 mins SETTING TIME – 8 to 10 mins
  • 48. PMMA (BONE CEMENT) • Mainly used to fix prosthesis in place can also be used as void fillers • Available as liquid and powder • The liquid contains: The monomer N,N-dimethyltoluidine (the accelerator)  Hydroquinone (the inhibitor)
  • 49. • Tough • Ductile • Resilient • Resistant to wear DISADVANTAGES • Susceptible to abrasion • Wear usually caused by third body inclusions • Thermoplastic (may be altered by extreme temperatures) • weaker than bone in tension ADVANTAGES USES: -It provides an excellent primary fixation of the prosthesis
  • 51. UHMWPE • A polymer of ethylene with MW of 2-6million • Used for acetabular cups in THR prostheses and tibial components in TKR • Metal on polyethylene has high success rate in bearing surface in THR • Osteolysis produced due to polyethylene wear debris causes aseptic loosening • Increases polymer chain cross- linking which improves wear characteristics
  • 52. BIODEGRADABLE POLYMERS • Polyglycolic acid, Polylactic acid, copolymers • As stiffness of polymer decreases, stiffness of callus increases • Hardware removal not necessary (reduces morbidity and cost)
  • 53. CARBON FIBRES APPLICATIONS: Total hip replacement Internal fixation for various fractures Spine surgeries DISADVANTAGES: Release of carbon debris in to surrounding medium
  • 55. TISSUE ADHESIVES PROPERTIES OF TISSUE ADHESIVES: • Moderately viscous (spread easily) • Ability to degrade at a appropriate rate • Biocompability Commonly used tissue adhesives are - fibrin gel,albumim,cyanoacrylates and mucopolysaccharides
  • 56. GENERAL TISSUE-IMPLANT RESPONSES • All implant materials elicit some response from the host • The response occurs at tissue-implant interface • Response depend on many factors; - Type of tissue/organ; - Mechanical load - Amount of motion - Composition of the implant - Age of patient
  • 57. TISSUE-IMPLANT RESPONSES BIOMATERIAL TOXIC NON TOXIC DEATH OF SURROUNDING TISSUES BIO ACTIVE BIO INERT FIBROUS ENCAPSULATION INTERFACIAL BOND FORMATION BIODEGRADABLE DISSOLUTION OF MATERIAL
  • 58. COMPLICATIONS • Aseptic Loosening: - Caused by osteolysis from body’s reaction to wear debris • Stress Shielding: - Implant prevents bone from being properly loaded • Corrosion: - Reaction of the implant with its environment resulting in its degradation to oxides/hydroxides
  • 59. COMPLICATIONS • Infection • Metal hypersensitivity • Manufacturing errors • VARIOUS FACTORS CONTRIBUTE TO IMPLANT FAILURE
  • 61. RECENT ADVANCES • Aim is to use materials with mechanical properties that match those of the bone • Modifications to existing materials to minimize harmful effects - Ex; nickel-free metal alloys • Possibility of use of anti-cytokine in the prevention of osteolysis around implants • Antibacterial implant
  • 62. RECENT ADVANCES • Porous tantalum is also being successfully used clinically in several orthopaedic applications. – high volumetric porosity, – low elastic modulus – good frictional characteristics • Ideal candidate for weight-bearing applications such as total joint arthroplasty
  • 63. CONCLUSION • Adequate knowledge of implant materials is an essential platform to making best choices for the patient • Promising and satisfying results from use of existing implant materials • Advances in biomedical engineering will go a long way in helping the orthopedic surgeon • The search is on…
  • 64. BIBLIOGRAPHY • CAMPBELLS OPERATIVE ORTHOPAEDICS 12th edition • KULKARNI textbook of othopaedics and trauma 2nd edition • http://www.ncbi.nlm.nih.gov/pmc/articles/P MC2706047/#bib197