anti parkinson

1. RESHMA KATWAL
ROLL NO – 12
COMS
ANTI-PARKINSON
AGENTS

2. OBJECTIVES
 INTRODUCTION
 ANTI-PARKINSON AGENTS
 INDICATIONS
 CONTRAINDICATION
 MECHANISM OF ACTION
 DOSAGE
 SIDE EFFECTS
 NURSE’S RESPONSIBILITES

3.  An anti-parkinson is a type of drug which is intended
to treat and relieve the symptoms of parkinson’s
disease.
 Most of these agents act by either increasing
dopamine activity or reducing acetylcholine activity
in the central nervous system.

4. CONTINUE
 In clinical practice, anti-cholinergic drugs,
amantadine, and the anti-histamines have their
primary use of treatment for medication induced
parkinsonism, acute dystonia, and medication
induced tremor.

5. ANTI PARKISONIAN AGENTS
 ANTI-CHOLINERGIC AGENTS
 Trihexyphenidyl
 Benztropine
 Biperiden
 DOPAMINERGIC AGENTS :
 Bromocriptine
 Carbidopa / levodopa

6. INDICATION
 Drug – induced parkinsonism.
 Adjunct in the management of parkinsonism

7. CONTRAINDICATION
1) Close angle glaucoma
2) Urinary and intestinal obstruction
3) Hypersensitivity
4) Tachycardia

8. MECHANISM OF ACTION
 It acts by increasing the release of dopamine from
pre-synaptic vesicles, blocking the re-uptake of
dopamine into pre-synaptic nerve terminals or by
exerting an agonist effect on post-synaptic dopamine
receptors.
 Trihexyphenidyl reaches peak plasma concentrations
in 2- 3 hours after oral administration and has
duration of action up to 12 hours.

9.  1 – 2 mg per day orally initially, maximum dose upto
15 mg per day in divided doses.

10. SIDE EFFECTS
 Dizziness
 Nervousness
 Drowsiness
 Weakness
 Headache
 Confusion
 Constipation
 Urinary retention
 Blurred vision

11. CONTINUE
• Tachycardia
 Orthostatic hypotension
 Dry mouth
 Nausea
 Vomitting
 Decreased sweating

13. NURSE’S RESPONSIBILITIES
 Assess parkinsonian and extra pyramidal symptoms.
 Caution patient to make position changes slowly.
 Instruct patient about frequent rinsing of mouth.
 Inform patient that this medication decreases
perspiration, and over heating may occur during hot
weather.

14. CONTINUE
 Assess seizure activities.
 Drug should be taken with food.
 Teach patient to carry medicine, alert I.D stating
patient’s name, drug taken.
 Teach patient not to stop medication without
medical advice.
 Advise patient to limit intake of alcohol and increase
protein containing food.