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How rapid is a rapid review?
Bianca Kramer
November 28, 2013
How long does it take to conduct
a systematic review?

Cochrane reviews 2010:
23 months (median)

The Cochrane Oversight Committee. Measuring the performance of The Cochrane Library. 2012
Cochrane reviews in numbers
2011
New reviews published

416

Updated reviews published

468

Active reviews that are up-to-date

36,5 %

The Cochrane Oversight Committee. Measuring the performance of The Cochrane Library. 2012
How rapid is a rapid review
How to do a systematic review
in a month (or less) ?

“I see a future for Cochrane as having
2 types of systematic review:
rapid systematic reviews undertaken in

a significantly reduced timeframe,
and a more costly systematic review”

http://blog.tripdatabase.com/2013/04/a-critique-of-cochrane-collaboration.html
How to do a systematic review
in a month (or less) ?
Formulate clinical question (PICO / DDO)

Systematic literature search

Selection (inclusion / exclusion criteria)

Critical appraisal (validity / relevance)

Summarize data
http://innovations.cochrane.org/response
http://innovations.cochrane.org/sites/innovations.cochrane.org/files/CHARR%20Evidence%20Summary-Final%2024May2013.pdf
Cochrane Response
Rapid Review example

- produced in 10 weeks
- 8291 references screened, 69 included
In general:
- 2-3 key databases,
- publication date/geographical location
- full-text availability
- focus on SRs, RCT/cohorts if necessary
Cochrane Response
Rapid Review example

- evidence synthesis: narrative
Percentage of studies that favour intervention:
0%
1-33 %
34-66 %
> 67 %

=
=
=
=

no effect
generally ineffective
mixed effects
generally effective

http://www.cadth.ca/en/resources/rx-for-change/interventions-professionals
Formulate clinical question (PICO / DDO)

Systematic literature search

Selection (inclusion / exclusion criteria)

Critical appraisal (validity / relevance)

Summarize data
How rapid is a rapid review
http://www.cochrane.org/news/tags/authors/webinar-introduction-rapid-reviews-30-jan-2014
Superfilters Website: A Literature Searching Tool
for Clinicians and Review Authors
Nancy L Wilczynski, N Hobson, C Cotoi, R Brian Haynes

“To develop a superfilters website that
provides clinicians and review authors with the

opportunity to search across several electronic
databases simultaneously with empirically derived,
high performance, search filters.”

http://www.isehc.net/wp-content/uploads/2011/12/October-2013.pdf
Superfilters Website: A Literature Searching Tool
for Clinicians and Review Authors
Nancy L Wilczynski, N Hobson, C Cotoi, R Brian Haynes

“To add „capture-mark-recapture‟ (CMR) statistical
modeling to the review authors‟ superfilter site to

help those searching for all available evidence to
determine whether to continue or stop searching,
for example, when conducting systematic reviews”

http://www.isehc.net/wp-content/uploads/2011/12/October-2013.pdf
http://en.wikipedia.org/wiki/File:Collar_tagged_Rock_Hyrax.jpg

http://en.wikipedia.org/wiki/File:Wing_tag_Great_Frigatebird.jpg
Formulate clinical question (PICO / DDO)

Systematic literature search

Selection (inclusion / exclusion criteria)

Critical appraisal (validity / relevance)

Summarize data
TRIP Rapid Reviews:
Systematic Reviews in 5 minutes ?
TRIP Rapid Reviews:
Systematic Reviews in 5 minutes ?

1) Enter domain and intervention
2) Select articles from list of TRIP search results
(controlled trials)
3) ...

http://blog.tripdatabase.com/2013/10/trip-rapid-reviews-systematic-reviews.html
http://commons.wikimedia.org/wiki/File%3AThe_Big_Red_Button_(3085157011).jpg
TRIP Rapid Reviews:
Systematic Reviews in 5 minutes ?

4) Machine reading of abstracts (2 methods)

→ intervention favoured? sample size?
5) Positive/Negative score (+1/-1), corrected for sample size

6) Scores for each article averaged → final score

http://blog.tripdatabase.com/2013/10/trip-rapid-reviews-systematic-reviews.html
Formulate clinical question (PICO / DDO)

Systematic literature search

Selection (inclusion / exclusion criteria)

Critical appraisal (validity / relevance)

Summarize data
How rapid is a rapid review
Reading list:

A critique of the Cochrane Collaboration
http://blog.tripdatabase.com/2013/04/a-critique-of-cochrane-collaboration.html

(Jon Brassey, TRIP Database)

Development of Cochrane Response part 1/2
http://www.slideshare.net/JulianeRied/development-of-cochrane-response-part-1-garritty
http://www.slideshare.net/JulianeRied/development-of-cochrane-response-part-ii

(Chantelle Garrity, OHRI, Canada)

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How rapid is a rapid review

  • 1. How rapid is a rapid review? Bianca Kramer November 28, 2013
  • 2. How long does it take to conduct a systematic review? Cochrane reviews 2010: 23 months (median) The Cochrane Oversight Committee. Measuring the performance of The Cochrane Library. 2012
  • 3. Cochrane reviews in numbers 2011 New reviews published 416 Updated reviews published 468 Active reviews that are up-to-date 36,5 % The Cochrane Oversight Committee. Measuring the performance of The Cochrane Library. 2012
  • 5. How to do a systematic review in a month (or less) ? “I see a future for Cochrane as having 2 types of systematic review: rapid systematic reviews undertaken in a significantly reduced timeframe, and a more costly systematic review” http://blog.tripdatabase.com/2013/04/a-critique-of-cochrane-collaboration.html
  • 6. How to do a systematic review in a month (or less) ? Formulate clinical question (PICO / DDO) Systematic literature search Selection (inclusion / exclusion criteria) Critical appraisal (validity / relevance) Summarize data
  • 9. Cochrane Response Rapid Review example - produced in 10 weeks - 8291 references screened, 69 included In general: - 2-3 key databases, - publication date/geographical location - full-text availability - focus on SRs, RCT/cohorts if necessary
  • 10. Cochrane Response Rapid Review example - evidence synthesis: narrative Percentage of studies that favour intervention: 0% 1-33 % 34-66 % > 67 % = = = = no effect generally ineffective mixed effects generally effective http://www.cadth.ca/en/resources/rx-for-change/interventions-professionals
  • 11. Formulate clinical question (PICO / DDO) Systematic literature search Selection (inclusion / exclusion criteria) Critical appraisal (validity / relevance) Summarize data
  • 14. Superfilters Website: A Literature Searching Tool for Clinicians and Review Authors Nancy L Wilczynski, N Hobson, C Cotoi, R Brian Haynes “To develop a superfilters website that provides clinicians and review authors with the opportunity to search across several electronic databases simultaneously with empirically derived, high performance, search filters.” http://www.isehc.net/wp-content/uploads/2011/12/October-2013.pdf
  • 15. Superfilters Website: A Literature Searching Tool for Clinicians and Review Authors Nancy L Wilczynski, N Hobson, C Cotoi, R Brian Haynes “To add „capture-mark-recapture‟ (CMR) statistical modeling to the review authors‟ superfilter site to help those searching for all available evidence to determine whether to continue or stop searching, for example, when conducting systematic reviews” http://www.isehc.net/wp-content/uploads/2011/12/October-2013.pdf
  • 17. Formulate clinical question (PICO / DDO) Systematic literature search Selection (inclusion / exclusion criteria) Critical appraisal (validity / relevance) Summarize data
  • 18. TRIP Rapid Reviews: Systematic Reviews in 5 minutes ?
  • 19. TRIP Rapid Reviews: Systematic Reviews in 5 minutes ? 1) Enter domain and intervention 2) Select articles from list of TRIP search results (controlled trials) 3) ... http://blog.tripdatabase.com/2013/10/trip-rapid-reviews-systematic-reviews.html
  • 21. TRIP Rapid Reviews: Systematic Reviews in 5 minutes ? 4) Machine reading of abstracts (2 methods) → intervention favoured? sample size? 5) Positive/Negative score (+1/-1), corrected for sample size 6) Scores for each article averaged → final score http://blog.tripdatabase.com/2013/10/trip-rapid-reviews-systematic-reviews.html
  • 22. Formulate clinical question (PICO / DDO) Systematic literature search Selection (inclusion / exclusion criteria) Critical appraisal (validity / relevance) Summarize data
  • 24. Reading list: A critique of the Cochrane Collaboration http://blog.tripdatabase.com/2013/04/a-critique-of-cochrane-collaboration.html (Jon Brassey, TRIP Database) Development of Cochrane Response part 1/2 http://www.slideshare.net/JulianeRied/development-of-cochrane-response-part-1-garritty http://www.slideshare.net/JulianeRied/development-of-cochrane-response-part-ii (Chantelle Garrity, OHRI, Canada)