Measurement of Radiation and Dosimetric Procedure.pptx
Presentation at ISMB NIH Office of Data Science Strategy Panel
1. Precisely Practicing Medicine from
700 Trillion Points of
University of California Health Data
Atul Butte, MD, PhD
Chief Data Scientist, University of California Health (UC Health)
Priscilla Chan and Mark Zuckerberg Distinguished Professor
Director, Bakar Computational Health Sciences Institute, UCSF
atul.butte@ucsf.edu ▪ @atulbutte
2. Conflicts of Interest
• Scientific founder and
advisory board membership
– Genstruct
– NuMedii
– Personalis
– Carmenta
• Honoraria for talks
– Lilly
– Pfizer
– Siemens
– Bristol Myers Squibb
– AstraZeneca
– Roche
– Genentech
– Warburg Pincus
– CRG
– AbbVie
– Westat
• Past or present consultancy
– Lilly
– Johnson and Johnson
– Roche
– NuMedii
– Genstruct
– Tercica
– Ecoeos
– Helix
– Ansh Labs
– uBiome
– Prevendia
– Samsung
– Assay Depot
– Regeneron
– Verinata
– Pathway Diagnostics
– Geisinger Health
– Covance
– Wilson Sonsini Goodrich & Rosati
– Orrick
– 10X Genomics
– GNS Healthcare
– Gerson Lehman Group
– Coatue Management
• Corporate Relationships
– Northrop Grumman
– Genentech
– Optum
– Aptalis
– Allergan
– Astellas
– Thomson Reuters
– Intel
– SAP
– SV Angel
– Progenity
– Illumina
• Speakers’ bureau
– None
• Companies started by students
– Carmenta
– Serendipity
– Stimulomics
– NunaHealth
– Praedicat
– MyTime
– Flipora
– Tumbl.in
– Polyglot
– Iota Health
– Ongevity Health
9. Build the STRONGEST TEAM in the world in
biomedical computation and health DATA INTELLIGENCE
• Academic affinity home for faculty and staff
• Recruit the best computational, informatics and AI faculty and staff to UCSF
• Develop new educational programs
• Provide a research computing platform and operations
• Build and use our data assets for precision medicine
• Research and development (and spin out technologies)
10. Faculty Recruitments
2015/16
2017/18
2019
2015-17
7
D Torgerson W Brown A Sweet-Cordero U Manber J Adler-Milstein T Goldstein A Raj
Peds DOM, DPM Peds DOM DOM, DHM Hem Onc Radiology
2018-19
7 M Sirota J Hong V Ntranos J Li D Chi B Rosner F Huang
Peds Rad Onc Diabetes Ctr Neurology Dentistry DOM, DHM DOM, Onc
11. University of California
• 10 campuses and 3 national labs
• ~200,000 employees, ~250,000 students/yr
UC Health
• 18 health professional schools (6 med schools)
• Train half the medical students and residents in
California
• ~$2 billion NIH funding
• $13+ billion clinical operating revenue
• 5000 faculty physicians, 12000 nurses
• UCSF and UCLA are in US News top 10
• 5 NCI Comprehensive Cancer Centers, 5 NIH CTSA
• IRB reliance, centralized contracting
12.
13.
14. UC Health Data Analytics Platform
Combining healthcare data from across the
six University of California medical schools and systems
Health Data Warehouse
15. • Combined EHR data from UCSF, UCLA, UC Irvine, UC Davis,
UC San Diego, and UC Riverside
• Total 15 million patients with an MRN, basic diagnosis data
• Central database built using OMOP (not Epic) as a data backend
– Structured data from 2012 to the present day
– 5.1 million patients with “modern” data
– 164M encounters, 124M procedures, 682M med orders, 703M diagnosis
codes, 1.7B lab tests and vital signs,
– OSHPD data, pathology and radiology text elements, death index
– Claims data from our self-funded plans now included
– Continually harmonizing elements
• Quality and performance dashboards
The University of California has an
incredible view of the medical system
22. 146817 tested
5166 positives (3.52% of tested)
1417 admitted to date (27.4% of positives)
117 expired (8.3% of admitted, 2.26% of positives)
23. • Switched from monthly data feeds to
daily data feeds
• Successfully sharing dashboard
elements and computer code across
campuses
• Harmonizing data elements: linking
Epic programmers with clinicians and
BRAID
• Validate quickly, update often
• Nature of the pandemic means
information flow to many responsible
agencies
23
What did we learn: How to work even more strongly together