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Rethinking treatment of PANDAS as a Neuro-Immune Condition

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What is PANDAS, What causes it? What do conventional and alternative approaches look like? The causes can differ per person. Find out what those possible health causes are...

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Rethinking treatment of PANDAS as a Neuro-Immune Condition

  1. 1. RETHINKING TREATMENT OF PANDAS By Dr. Alex Rinehart, DC, MS, CNS https://www.DrAlexRinehart.com
  2. 2. PANDAS - Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections  PANDAS is when neurological symptoms present following acute or persistent Streptococcus infection.  Microorganisms such as Streptococcus sp. have the potential to cause and worsen behavioral/neurological conditions. One variant is PANDAS.  Current medical diagnosis often limited to OCD or other specific behavioral/neurological presentations - Immune/Post-infectious component can be overlooked.
  3. 3. • Autoimmune in nature – a process known as Molecular Mimicry. Molecular Mimicry - antibodies targeting bacteria, toxins, & food proteins mistake parts of healthy tissue as the enemy. Healthy tissue can “mimic” an invader on a microscopic level.  Immune Overactivation can happen with acute & chronic infections (food rxn, heavy metals, etc). Become “trigger-happy” • Functional Health: Infection affects individuals differentially (adrenals, food allergies/sensitivities, immune balance, gut health, coinfections, breastfeeding history, Vitamin D levels etc.) Streptococcal infection + Molecular Mimicry + Immune Overactivation + Health Susceptibilities higher PANDAS probability What is the Underlying Mechanism of PANDAS?
  4. 4. • Function can be measured on a spectrum of what’s “healthy” and “normal” in anyone. • Foundational health issues (stress, gut function, immune triggers, etc.) - many overlapping symptoms improve when these foundational factors are addressed. • The cause(s) of immune overactivation will differ person-to-person – no “silver bullet” approach • Functional medicine is a bridge between alternative & conventional medicine; it is not always a full substitute for conventional care. How Does a Functional Approach Work?
  5. 5. Connecting an Underlying CAUSE  Molecular mimicry is not limited to PANDAS  Sydenham’s chorea (a movement disorder) is also known to present following acute infection with Streptococcus.  Rheumatic fever occurs when GABHS antibodies cross-react with multiple tissues such as the heart, joints, and skin.  Lyme disease may also present with various neurological presentations –due to activity of the spirochete and the numerous co-infections.  In PANDAS, symptoms are diverse, making it hard to diagnose.  A functional healthcare lens is necessary to address the array of causes  A common theme is Immune Overactivation affecting the nervous system
  6. 6. • Conventional treatment for PANDAS may include penicillin treatment, immunoglobulin therapy, plasmapheresis as well as tonsillectomy. • While conventional approaches may be limited, alternative approaches may offer some clues to what’s missing in care. • Gut function, bacteria and yeast influence neurological health. When you improve digestion and gut flora, you have a functional effect on immune & nervous system health. • Symptoms may present in the nervous system; the functional cause may be outside of the nervous system. Conventional Treatment of PANDAS
  7. 7. Alternative Approach to PANDAS  Acute and Chronic Infections (Virus, Bacteria, Yeast)  Allergies/Sensitivities (Food, Chemicals, Environmental toxins, Household products)  Chronic Stress (Cortisol, DHEA, and others)  Leaky gut/dysbiosis (Creates general environment for hypersensitivity reactions)  Exposure to heavy metals and toxins (Can trigger autoimmune presentations)  Poor Detoxification/Liver and Kidney Clearance (methylation, liver function, hormones)
  8. 8. Get nutrition tips from Dr. Alexander Rinehart DR. ALEXANDER RINEHART, DC, CNS Owner, DrAlexRinehart.com • See original article (with references): Rethinking Treatment of PANDAS • Shop Professional Supplements Get More Nutrition Tips!

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