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Gestational Diabetes Yannis Dimitropoulos ST3 in Diabetes and Endocrinology Torbay Hospital Buckfast Abbey Diabetes and Endocrinology Training  Day 07/05/2010
What we will Cover ,[object Object],[object Object],[object Object]
GESTATIONAL DIABETES(GDM) ,[object Object],[object Object]
Why does Gestational Diabetes Mellitus happen? ,[object Object],[object Object],[object Object]
Deterioration of  ÎČ  cell function  and insulin resistance in Type 2 diabetes 0 20 40 60 80 100 Age ß-cell function (%) – 10 –8 –6 –4 –2 0 2 4 6 – 12 30 40 50 60 70
Deterioration of  ÎČ  cell function  and insulin resistance in  Gestational DM   0 20 40 60 80 100 Age ß-cell function (%) – 10 –8 –6 –4 –2 0 2 4 6 – 12 30 40 50 60 70
Why is it important to treat Gestational Diabetes?
Pedersen Hypothesis (1954) ,[object Object],[object Object]
Australian Carbohydrate Intolerance Study in Pregnant Women (ACHOIS) 2005 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
ACHOIS Results Outcome Intervention  Routine Group Infants Number Number  Total number 506 524 Birth weight 3335g 3482g Macrosomia (>4kg) 49  (10%) 110  (21%) Death  (Neonatal/Stillbirth) 0  5  Stillbirth 0 3  Shoulder dystocia 7  16  Bone fracture  0 1  Nerve palsy 0 3  Jaundice  44  48
Hyperglycaemia and Adverse Pregnancy Outcomes (HAPO) 2008 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hyperglycaemia and Adverse Pregnancy Outcomes (HAPO) 2008 ,[object Object],[object Object]
 
International Association of Diabetes and Pregnancy Study Groups (IADPSG) Consensus panel (2008) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
NICE Guidelines 2008
CEMACH: adverse outcomes in pregnant women with type 1 and type 2 diabetes, 2002/3 and 2007
NICE -Risks of Gestational Diabetes in Pregnancy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
NICE -Risk Factors for Screening for GDM ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The Torbay Hospital Antenatal Diabetes Clinic referral process ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Low  vs. High Risk GDM management ,[object Object],[object Object],[object Object]
The Torbay Hospital Diabetes Antenatal Clinic ,[object Object],[object Object],[object Object],[object Object],[object Object]
The Torbay Hospital Diabetes Antenatal Clinic ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The Torbay Hospital Diabetes Antenatal Clinic ,[object Object],[object Object],[object Object],[object Object],[object Object]
REFERENCES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object]

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Integumentary System SMP B. Pharm Sem I.ppt
 

Gestational diabetes

  • 1. Gestational Diabetes Yannis Dimitropoulos ST3 in Diabetes and Endocrinology Torbay Hospital Buckfast Abbey Diabetes and Endocrinology Training Day 07/05/2010
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  • 5. Deterioration of ÎČ cell function and insulin resistance in Type 2 diabetes 0 20 40 60 80 100 Age ß-cell function (%) – 10 –8 –6 –4 –2 0 2 4 6 – 12 30 40 50 60 70
  • 6. Deterioration of ÎČ cell function and insulin resistance in Gestational DM 0 20 40 60 80 100 Age ß-cell function (%) – 10 –8 –6 –4 –2 0 2 4 6 – 12 30 40 50 60 70
  • 7. Why is it important to treat Gestational Diabetes?
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  • 10. ACHOIS Results Outcome Intervention Routine Group Infants Number Number Total number 506 524 Birth weight 3335g 3482g Macrosomia (>4kg) 49 (10%) 110 (21%) Death (Neonatal/Stillbirth) 0 5 Stillbirth 0 3 Shoulder dystocia 7 16 Bone fracture 0 1 Nerve palsy 0 3 Jaundice 44 48
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  • 16. CEMACH: adverse outcomes in pregnant women with type 1 and type 2 diabetes, 2002/3 and 2007
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Hinweis der Redaktion

  1. Type 2 diabetes is typically not diagnosed until Beta cell function has been significantly impaired. After diagnosis, beta cell function deteriorates linearly with time. Extrapolating back a graph of time vs. function from the UKPDS suggests that beta cell dysfunction begins many years before it results in a clinical presentation of type two diabetes.
  2. Type 2 diabetes is typically not diagnosed until Beta cell function has been significantly impaired. After diagnosis, beta cell function deteriorates linearly with time. Extrapolating back a graph of time vs. function from the UKPDS suggests that beta cell dysfunction begins many years before it results in a clinical presentation of type two diabetes.
  3. Women with at least one risk factor for GDM GTT 24-34 weeks – FPG <7.8 and 2-hr 7-8 - 11 1000 randomly assigned to ‘Intensive’ versus ‘Routine’ care ‘ Routine care’ – patients and physicians were not aware of the diagnosis of GDM
  4. 23,316 pregnant women at 15 centres in 9 countries with 75-g oral glucose-tolerance testing at 24 to 32 weeks of gestation. Blinded if fasting glucose <5.8 and 2-hour glucose <11.1 mmol/l
  5. Reviewed the evidence from HAPO, ACHOIS and all other available smaller randomized trials.
  6. NICE implies oral treatments as good as insulin.