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BEHAVIORAL PLANNING FOR
                     CHILDREN WITH PERVASIVE
                     DEVELOPMENTAL DISORDERS?

pallav pareek m.d.
january 11th 2013
Objectives
   Case discussion
   Journal Article:
   Discussion and exchange of
    ideas
-   Is a behavioral plan
    required?
-   Does a neurotypical
    behavioral plan work in PDD?
-   What modifications (if any)
    are required?
-   Resources in St. Louis Metro
    Area?
Autism Fact Sheet
   1 in 88 children and 1 in 54 boys
   Autism is the fastest-growing
    serious developmental disability in
    the U.S.
   Autism costs a family $60,000 a
    year on average
   Autism receives less than 5% of the
    research funding of many less
    prevalent childhood diseases.
   0.55% of total NIH funding.
   40% of children with autism do not
    speak
Major areas of Target for ASD’s


                   Behavior


                    Social


                 Communication
Some Challenging Behaviors in ASD’s

             • Aggression is a high-profile behavior
               that garners more attention
             • Is aggression a reaction to frustration
Aggression     and difficulty with appropriately
               communicating affect state or
               identifying alternative reactions to
               frustrating experiences




             • SIB is similar to (?) stereotypies with
    Self       respect to the rhythmical and
               repetitive nature of the behavior, but
 Injurious     in the case of SIB, tissue damage
               often results

Behaviors
Trivia!!
   What is the average cost of ABA for a family per
    annum?
Some things that worked…
    Body Bag, Shredder App, Lifting
     Weights, Trampoline, Carrying pumpkins etc..
History of ABA
      Watson fed up with “hypothetico-deductivo
       reasoning”→Experimental Analysis of Behavior →B. F
       Skinner
      Initially known as Behavioral Mod
      Lovaas is one of the pioneers: In early years aversives
       (Strikes, shouting, shocks) 10 Now mostly positive reinforcers
      Judge Rotenberg Center (formerly Behavior Research
       Institute) Canton, Massachusetts
      In the initial studies by Dr. Lovaas11: There were claims of up
       to 47% children→ mainstream→ indistinguishable
      Remains the most popular and most evidenced based
       approach for Autism
10: Moser D, Grant A (1965-05-07). "Screams, slaps and love". Life
11:Lovaas, O. I. (1987). Behavioral treatment and normal intellectual and educational functioning in autistic children. Journal of Consulting and Clinical Psychology, 55, 3-9
Components of ABA

    NRC: Recommends:25 hrs/wk of structured training
    DTT is used to reduce stereotypical autistic behaviours
     through extinction and the provision of socially
     acceptable alternatives to self-stimulatory behaviors
    EIBI: usually 30hrs/week 2-6 years
    Typical sessions: 5-6 hours, with natural breaks with
     child tiring. Positive reinforcers: verbal/food/anything

13: Baer, D.M.; Wolf, M.M.; Risley, T.R. (1968). "Some current dimensions of applied behavior analysis". J Appl Behav Anal 1 (1): 91–97.
http://www.nrc-cnrc.gc.ca/eng/index.html
.




   1/11/13




              pallav pareek m.d.
              clinical case conference
              january 11th 2013
"In a field rife with fads, pseudoscience, and popular, yet
unproven, interventions….National Standards Project are a
welcome and much-needed counterbalance to much of the
hyperbole for both professionals and families” Peter F.
Gerhardt


                  National Autism Center: National Standards
                   Project, to produce a set of standards for
                   effective, research-validated education and
                   behavioral intervention

              http://www.nationalautismcenter.org/about/national.php
Introduction
   Growing evidence supports the use of intensive
    behavioral intervention (IBI)
   Two decades of studies have supported the use of
    typical/atypical antipsychotics in treatment of
    aggression in ASD
   No studies comparing antipsychotics to other med
    classes or combined with IBI
Introduction Contd:
   ? Phenotypic overlap BD and ASD suggests mood
    stabilizers may be an option
   ADHD+Sleep prompt use of non-stimulant ADHD
    meds (α agonist), not for aggression
   Aims to see effects of IBI with AP/MS/NS
Hypotheses
1.   IBI shall substantially decrease aggressive behaviors
     in youth with ASD
2.   Time required to achieve behavior plan success
     lower in individuals taking AP/MS/NS relative to
     those not taking medication
3.   Younger, verbal males w low baseline aggression &
     lower stereotypy, irritability, and hyperactivity who
     received DRO plan predicted succeed quicker
Methods
   32 children attending IBI program in Cleveland.
    Mean age 11.16 (4-16) 75% male
   DSM diagnosis with Autistic disorder or PDD NOS
    were eligible if they received IBI for aggression
   Consecutive youths in retrospective review of charts
    between 2000-2007
Methods cont:
   All receiving IBI≥ 30 hrs/week. No additional
    behavioral therapies.
   Aggression: Any beh that harms/attempts to harm
    another/destruction of property. Also interferes with
    academics/scoialization/daily living & restricts access
    to community involvement
   Inclusion: ↑ 4 aggressive beh/day + 1 day with
    multiple aggressive beh were included
Methods cont:
   Aggressive beh recorded at baseline (1 wk before
    IBI) and then wk 1-3 after beh plan implementation
   Success: defined as↓ 1 agg ep/day for 5 consecutive
    days & five session without mod/severe aggression
   Medications: Prescribed as usual by ped
    neurologist/psychiatrist/dev pediatrician. (No specific
    algorithm used) on meds >2 weeks prior
Medications

  AP: risp12, ari5, zip1, clo1, zyp1, mol1
  n=3 on 2 AP’s


 MS: dival6, lithium3, lamo1


 NS: clonidine11, atom1


 3= all classes 6= AP+MS 4= AP+NS
Measures
   ABC (Community) completed by classroom teacher
    30-35/wk : Hyperactivity, stereotypy and
    irritability subscales used
   VABS (Teacher rating form) to evaluate functl level
Results
                                         Number of sessions required to succeed
Changes in frequency of aggressive beh   with agg beh plan
# of sessions required w/wo
medication
# of sessions required for success by
sex/verbal ability
Strengths and Limitations

LIMITATIONS                      STRENGTHS

   Intermingled med classes
   Retrospective
   Comorbidities
   Reason to be on one
    medication class vs. other
   Medication dosages?
   Evaluating combinations
   No Randomization (for IBI
    or meds)
Take Home
   No Extinction burst observed
   Median number of 6 hour sessions needed >30
   No difference between DRO vs. DRA
   MS & NS meds have minimal effect in augmenting
    aggression beh plans.
Thank You!!


Autists are the ultimate square
pegs, and the problem with
pounding a square peg into a
round hole is not that the
hammering is hard work. It's that
you're destroying the peg.” Paul
Collins

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Behavioral Interventions in children with Pervasive Developmental Disorders

  • 1. BEHAVIORAL PLANNING FOR CHILDREN WITH PERVASIVE DEVELOPMENTAL DISORDERS? pallav pareek m.d. january 11th 2013
  • 2. Objectives  Case discussion  Journal Article:  Discussion and exchange of ideas - Is a behavioral plan required? - Does a neurotypical behavioral plan work in PDD? - What modifications (if any) are required? - Resources in St. Louis Metro Area?
  • 3. Autism Fact Sheet  1 in 88 children and 1 in 54 boys  Autism is the fastest-growing serious developmental disability in the U.S.  Autism costs a family $60,000 a year on average  Autism receives less than 5% of the research funding of many less prevalent childhood diseases.  0.55% of total NIH funding.  40% of children with autism do not speak
  • 4. Major areas of Target for ASD’s Behavior Social Communication
  • 5. Some Challenging Behaviors in ASD’s • Aggression is a high-profile behavior that garners more attention • Is aggression a reaction to frustration Aggression and difficulty with appropriately communicating affect state or identifying alternative reactions to frustrating experiences • SIB is similar to (?) stereotypies with Self respect to the rhythmical and repetitive nature of the behavior, but Injurious in the case of SIB, tissue damage often results Behaviors
  • 6. Trivia!!  What is the average cost of ABA for a family per annum?
  • 7. Some things that worked…  Body Bag, Shredder App, Lifting Weights, Trampoline, Carrying pumpkins etc..
  • 8. History of ABA  Watson fed up with “hypothetico-deductivo reasoning”→Experimental Analysis of Behavior →B. F Skinner  Initially known as Behavioral Mod  Lovaas is one of the pioneers: In early years aversives (Strikes, shouting, shocks) 10 Now mostly positive reinforcers  Judge Rotenberg Center (formerly Behavior Research Institute) Canton, Massachusetts  In the initial studies by Dr. Lovaas11: There were claims of up to 47% children→ mainstream→ indistinguishable  Remains the most popular and most evidenced based approach for Autism 10: Moser D, Grant A (1965-05-07). "Screams, slaps and love". Life 11:Lovaas, O. I. (1987). Behavioral treatment and normal intellectual and educational functioning in autistic children. Journal of Consulting and Clinical Psychology, 55, 3-9
  • 9. Components of ABA  NRC: Recommends:25 hrs/wk of structured training  DTT is used to reduce stereotypical autistic behaviours through extinction and the provision of socially acceptable alternatives to self-stimulatory behaviors  EIBI: usually 30hrs/week 2-6 years  Typical sessions: 5-6 hours, with natural breaks with child tiring. Positive reinforcers: verbal/food/anything 13: Baer, D.M.; Wolf, M.M.; Risley, T.R. (1968). "Some current dimensions of applied behavior analysis". J Appl Behav Anal 1 (1): 91–97. http://www.nrc-cnrc.gc.ca/eng/index.html
  • 10. .  1/11/13 pallav pareek m.d. clinical case conference january 11th 2013
  • 11. "In a field rife with fads, pseudoscience, and popular, yet unproven, interventions….National Standards Project are a welcome and much-needed counterbalance to much of the hyperbole for both professionals and families” Peter F. Gerhardt  National Autism Center: National Standards Project, to produce a set of standards for effective, research-validated education and behavioral intervention http://www.nationalautismcenter.org/about/national.php
  • 12. Introduction  Growing evidence supports the use of intensive behavioral intervention (IBI)  Two decades of studies have supported the use of typical/atypical antipsychotics in treatment of aggression in ASD  No studies comparing antipsychotics to other med classes or combined with IBI
  • 13. Introduction Contd:  ? Phenotypic overlap BD and ASD suggests mood stabilizers may be an option  ADHD+Sleep prompt use of non-stimulant ADHD meds (α agonist), not for aggression  Aims to see effects of IBI with AP/MS/NS
  • 14. Hypotheses 1. IBI shall substantially decrease aggressive behaviors in youth with ASD 2. Time required to achieve behavior plan success lower in individuals taking AP/MS/NS relative to those not taking medication 3. Younger, verbal males w low baseline aggression & lower stereotypy, irritability, and hyperactivity who received DRO plan predicted succeed quicker
  • 15. Methods  32 children attending IBI program in Cleveland. Mean age 11.16 (4-16) 75% male  DSM diagnosis with Autistic disorder or PDD NOS were eligible if they received IBI for aggression  Consecutive youths in retrospective review of charts between 2000-2007
  • 16. Methods cont:  All receiving IBI≥ 30 hrs/week. No additional behavioral therapies.  Aggression: Any beh that harms/attempts to harm another/destruction of property. Also interferes with academics/scoialization/daily living & restricts access to community involvement  Inclusion: ↑ 4 aggressive beh/day + 1 day with multiple aggressive beh were included
  • 17. Methods cont:  Aggressive beh recorded at baseline (1 wk before IBI) and then wk 1-3 after beh plan implementation  Success: defined as↓ 1 agg ep/day for 5 consecutive days & five session without mod/severe aggression  Medications: Prescribed as usual by ped neurologist/psychiatrist/dev pediatrician. (No specific algorithm used) on meds >2 weeks prior
  • 18. Medications AP: risp12, ari5, zip1, clo1, zyp1, mol1 n=3 on 2 AP’s MS: dival6, lithium3, lamo1 NS: clonidine11, atom1 3= all classes 6= AP+MS 4= AP+NS
  • 19. Measures  ABC (Community) completed by classroom teacher 30-35/wk : Hyperactivity, stereotypy and irritability subscales used  VABS (Teacher rating form) to evaluate functl level
  • 20. Results Number of sessions required to succeed Changes in frequency of aggressive beh with agg beh plan
  • 21. # of sessions required w/wo medication
  • 22. # of sessions required for success by sex/verbal ability
  • 23. Strengths and Limitations LIMITATIONS STRENGTHS  Intermingled med classes  Retrospective  Comorbidities  Reason to be on one medication class vs. other  Medication dosages?  Evaluating combinations  No Randomization (for IBI or meds)
  • 24. Take Home  No Extinction burst observed  Median number of 6 hour sessions needed >30  No difference between DRO vs. DRA  MS & NS meds have minimal effect in augmenting aggression beh plans.
  • 25. Thank You!! Autists are the ultimate square pegs, and the problem with pounding a square peg into a round hole is not that the hammering is hard work. It's that you're destroying the peg.” Paul Collins