Body Fluids Composition and Regulation

[object Object],Body composition % of body weight Body composition 18% Protein, & related substances 15% Fat 7% Mineral 60% Water

Body Fluids ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Fluid Compartments  60% of body weight ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Transcellular fluid CSF Intraocular Pleural Peritoneal Pericardial Synovial Digestive secretions

Example: How to calculate total body water (TBW)? ,[object Object],[object Object],[object Object]

Differences between ECF & ICF ECF Anions : Cl - (108) HCO 3 - (24) Cations : Na + (142 mmol/L ) K + (4.2) Mg 2+ (0.8) Nutrients : O 2 , glucose, fatty acids, & amino acids. Wastes : CO 2 , Urea, uric acid, excess water, & ions. ICF Anions : Cl - (4) HCO 3 - (10) Phosphate ions Cations : Na + (14) K + (140) Mg 2+ (20) Nutrients : High concentrations of proteins.

COMPOSITION OF BODY FLUIDS CATIONS (mmol/l) Plasma Interstitial Intracellular Na 142 139 14 K 4.2 4.0 140 Ca 1.3 1.2 0 Mg 0.8 0.7 20 ANIONS (mmol/l) Cl 108 108 4.0 HCO3 24.0 28.3 10 Protein 1.2 0.2 4.0 HPO4 2.0 2.0 11

Extracellular and Intracellular Fluids ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

IMPORTANCE ,[object Object],[object Object],[object Object],[object Object]

Basic Definitions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Basic Definitions Tonicity Osmolality Physiological term (effective Os P relative to plasma) Solutes that do not cross the cell membrane only counts Chemical term All solutes contributes to Osmolality 2 x Na + + Glucose 285 mOsm/kg Na + x 2 + glucose + BUN 290 mOsm/kg

VOLUME OF BODY FLUIDS IN 70 kg MAN ,[object Object],[object Object],INTRA CELLUAR FLUID 28 L (ROUGHLY 2/3 OF TBW) EXTRA CELLULAR FLUID 14 L (ROUGHLY 1/3 OF TBW) PLASMA 4 L (ROUGHLY ¼ OF ECF)

METHODS OF MEASUREMENTS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],INDIRECT METHOD – INDICATOR (DYE) DILUTION TECHNIQUE FORMULA V=A-E/C

[object Object],[object Object],VOLUME MEASUREMENT OF VARIOUS FLUIDS COMPARTMETNS INTRACELLULAR FLUID TBW – ECF

CRITERIA FOR A SUITABEL DYE. ,[object Object],[object Object],[object Object],[object Object],[object Object]

VOLUME MEASUREMENT OF VARIOUS FLUIDS COMPARTMETNS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],VOLUME MEASUREMENT OF VARIOUS FLUIDS COMPARTMETNS

[object Object],[object Object],[object Object],VOLUME MEASUREMENT OF VARIOUS FLUIDS COMPARTMETNS TOTAL BLOOD VOLUME PLASME VOL X 100 100 -HCT

FACTORS AFFECTING ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Dehydration ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Disorders of Water Balance: Hypotonic Hydration ,[object Object],[object Object],[object Object],[object Object]

Disorders of Water Balance: Edema ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Regulation of ECF Volume ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

ECF volume receptors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Hormonal Regulation of Blood Volume 27-

Regulation of Water Intake Figure 27.5

Body Fluids Composition and Regulation

Empfohlen

Empfohlen

Weitere ähnliche Inhalte

Was ist angesagt?

Was ist angesagt? (20)

Andere mochten auch

Andere mochten auch (20)

Ähnlich wie Body Fluids Composition and Regulation

Ähnlich wie Body Fluids Composition and Regulation (20)

Mehr von Lawrence James

Mehr von Lawrence James (20)

Kürzlich hochgeladen

Kürzlich hochgeladen (20)

Body Fluids Composition and Regulation