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LECTURE 4b
URINARY SYSTEM
(DR. B.M. KAVOI)
Lecture urinary system histology
• Main components of this system- 1. Kidneys, 2.
Ureter, 3. Urinary bladder and 4. Urethra
1. KIDNEY
•Parenchyma organized
into cortex (F) and
medulla (E)
•Within parenchyma occur
nephrones, collecting
ducts, blood vessels,
lymphatics and nerves
•Parenchyma organized
into lobes and lobules
Lobes and lobules
• Lobes are located btw adjacent renal columns with
peripheral limits within medulla being the interlobar
arteries
• A renal lobule is defined as a portion of the kidney
containing those nephrons that are drained by a
common collecting duct.
• At the cortex, the collecting duct lies at the axis of
lobule, being surrounded by corticolabyrinth or
network comprising of renal corpuscles, PCT and
DCT
• Lobules are centered on "medullary rays“, which
are bundles of straight tubules (collecting ducts
and loops of Henle)
• Within the cortex, peripheral limits of a lobule are
the interlobular blood vessels while in medulla,
limits of lobules are not defined
Nephron
• Tubules in which urine is
formed (functional unit of the
kidney
• Form the most abundant tissue
of renal parenchyma
• Consist of 5 parts;
i. Renal corposule,
ii. Proximal convoluted tubule
iii. Medullary loop (loop of
Henle)
iv. Distal convoluted tubule
v. Collecting duct
i. Renal corpuscle
• Produces glomerular
ultrafiltrate
• Is a spherical structure
comprising of
a) cluster of blood
vessels= glomerulus
b) double walled
envelope= glomerular
or Bowman’s
capsule
• Efferent arterioles enter while the afferent arterioles leave
the glomerulus at vascular pole while ultrafiltrate leave
corpuscle at renal pole
• Capillaries forming glomerulus are fenestrated and their
endothelium rests on a thick basal lamina
• Bowman’s capsule comprise of inner visceral and outer
parietal layers and Bowmans space in btw the layers
• Parietal layer is formed by simple squamous cells while
visceral is formed by podocytes, whose foot processes
(pedicels) contact glomerular blood capillaries
• The connective tissue stroma of the glomerulus is
constituted by mesangial cells, which support the
glomerular capillaries
ii.Proximal convoluted tubule
• Reabsorption of water,
nutrients and solids
(obligatory)
• Lined by simple cuboidal
epithithelium resting on a thin
b. lamina
• Tubule cells have microvilli on
their luminal surfaces (typical
brush border)
• Tubule cells appear striated
due to numerous basal
infoldings & plenty of
mitochondria
iii.Medullary loop
• Functions as a counter-current
multiplier system to determines
osmolarity of urine; blood flow in the
loop is counter to that in medullary
vasa recta.
• Extends from corticomedullary junction
to medulla
• Consists of an descending limb, a thin
segment and a ascending limb
• The thin part is lined by simple
squamous epithelium resting on a thin
BL; the sq cells sq. cells bulge into the
lumen of tubule
iv.Distal convoluted tubule
• Reabsorbs most of substances
contained in ultrafiltrate
especially glucosa and amino
acids (mainly facultative)
• Reabsorption regulated by
ADH and aldosterone
• Continues from the m. loop
and extends to collecting
tubule within cortex
• Lined by low simple cuboidal
epithelium resting on a thin BL
• The cells lack microvilli but are
striated, with basal infoldings
and but less mitochondria
• Its epithelial cells stain less
osmophilic compared to those
of PCT
Juxtaglomerular apparatus
• Formed where the DCT contacts the afferent arteriole of parent r.
corpuscle
• Constituted by 3 cell types;
i. macular densa cells of DCT (t. cells that become columnar & closely
packed)
ii.Juxtaglomerular cells of afferent arteriole (smooth muscle cells of
tunica media that become spherical and contain renin granules)
iii. Extraglomerular mesangial cells (similar to those within glomerulus
and surrounded by thick BL)
• Produce renin which converts angiotensinogen to angiotensin, (a
vasoconstricter which raises bld pressure thus flow of ultrafiltrate)
v. Collecting tubule
• Drain urine from nephron to renal pelvis
• Lie on medullary ray within cortex
• Progressively increase in diameter
towards medullar
• In inner medullar, CD from different renal
lobes unite to form large papillary ducts,
which open into renal pelvis
• Drain urine from nephron to r. pelvis
• Progressively increase in diameter
towards medullar
• In inner medullar, unite with other CDs
to form large papillary ducts, which
open into renal pelvis
• CD are lined by epithelium that has 2
cell types
1. collecting duct cells –
cuboidal in cortical part,
columnar in medullary
2. intercalated /dark cells-
resemble those of DCT but
bulge into lumen of the CD
• Both cell types rest on a thin BM and
lack basal infoldings
• Permeability of CD to water and ions is
regulated by ADH
URETER
• Conducts urine from kidney
to bladder
• Has 3 tissue layers
1. Tunica mucosa; lined by 5-
6 cell layer of transitional
epith that rests on lamina
propria of loose c. tissue
having bld vessels,
lymphatics and with tubular
mucus glands in the
equidae
2. T. muscularis; has inner
and outer longitudinal and
middle layer of smooth
muscles
3. T. serosa/ adventitia
Urinary bladder
• Its wall has 4 tissue layers;-
1. Tunica mucosa; lined by up to
14 cell layers of transitional
epith that rests on lamina
propria of loose c. tissue
2. T. submucosa; highly vascular
and rich in elastic fibers
3. T. muscularis; has inner and
outer longitudinal and middle
layer of smooth muscles
(dextruser muscles)
4. T. serosa/ adventitia
• The longi muscles form
sphincters at ureterovesicular
junction to prevent backflow of
urine and at neck of bladder to
regulate urine emptying
Urethra
• Its wall has 4 tissue layers
1. Tunica mucosa; epith
transitional but changes to
stratified squamous at external
urethral orifice
2. T. submucosa; has cavernous
tissue spaces that are typical of
erectile tissue
3. T. muscularis; has inner and
outer longi and middle layer of
smooth muscles as in bladder
but towards external urethral
orifice, it acquires an external
layer of skeletal muscle called
striated urethralis muscle
4. T. serosa/ adventitia

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Lecture urinary system histology

  • 3. • Main components of this system- 1. Kidneys, 2. Ureter, 3. Urinary bladder and 4. Urethra 1. KIDNEY •Parenchyma organized into cortex (F) and medulla (E) •Within parenchyma occur nephrones, collecting ducts, blood vessels, lymphatics and nerves •Parenchyma organized into lobes and lobules
  • 4. Lobes and lobules • Lobes are located btw adjacent renal columns with peripheral limits within medulla being the interlobar arteries • A renal lobule is defined as a portion of the kidney containing those nephrons that are drained by a common collecting duct.
  • 5. • At the cortex, the collecting duct lies at the axis of lobule, being surrounded by corticolabyrinth or network comprising of renal corpuscles, PCT and DCT • Lobules are centered on "medullary rays“, which are bundles of straight tubules (collecting ducts and loops of Henle) • Within the cortex, peripheral limits of a lobule are the interlobular blood vessels while in medulla, limits of lobules are not defined
  • 6. Nephron • Tubules in which urine is formed (functional unit of the kidney • Form the most abundant tissue of renal parenchyma • Consist of 5 parts; i. Renal corposule, ii. Proximal convoluted tubule iii. Medullary loop (loop of Henle) iv. Distal convoluted tubule v. Collecting duct
  • 7. i. Renal corpuscle • Produces glomerular ultrafiltrate • Is a spherical structure comprising of a) cluster of blood vessels= glomerulus b) double walled envelope= glomerular or Bowman’s capsule
  • 8. • Efferent arterioles enter while the afferent arterioles leave the glomerulus at vascular pole while ultrafiltrate leave corpuscle at renal pole • Capillaries forming glomerulus are fenestrated and their endothelium rests on a thick basal lamina • Bowman’s capsule comprise of inner visceral and outer parietal layers and Bowmans space in btw the layers • Parietal layer is formed by simple squamous cells while visceral is formed by podocytes, whose foot processes (pedicels) contact glomerular blood capillaries • The connective tissue stroma of the glomerulus is constituted by mesangial cells, which support the glomerular capillaries
  • 9. ii.Proximal convoluted tubule • Reabsorption of water, nutrients and solids (obligatory) • Lined by simple cuboidal epithithelium resting on a thin b. lamina • Tubule cells have microvilli on their luminal surfaces (typical brush border) • Tubule cells appear striated due to numerous basal infoldings & plenty of mitochondria
  • 10. iii.Medullary loop • Functions as a counter-current multiplier system to determines osmolarity of urine; blood flow in the loop is counter to that in medullary vasa recta. • Extends from corticomedullary junction to medulla • Consists of an descending limb, a thin segment and a ascending limb • The thin part is lined by simple squamous epithelium resting on a thin BL; the sq cells sq. cells bulge into the lumen of tubule
  • 11. iv.Distal convoluted tubule • Reabsorbs most of substances contained in ultrafiltrate especially glucosa and amino acids (mainly facultative) • Reabsorption regulated by ADH and aldosterone • Continues from the m. loop and extends to collecting tubule within cortex • Lined by low simple cuboidal epithelium resting on a thin BL • The cells lack microvilli but are striated, with basal infoldings and but less mitochondria • Its epithelial cells stain less osmophilic compared to those of PCT
  • 12. Juxtaglomerular apparatus • Formed where the DCT contacts the afferent arteriole of parent r. corpuscle • Constituted by 3 cell types; i. macular densa cells of DCT (t. cells that become columnar & closely packed) ii.Juxtaglomerular cells of afferent arteriole (smooth muscle cells of tunica media that become spherical and contain renin granules) iii. Extraglomerular mesangial cells (similar to those within glomerulus and surrounded by thick BL) • Produce renin which converts angiotensinogen to angiotensin, (a vasoconstricter which raises bld pressure thus flow of ultrafiltrate)
  • 13. v. Collecting tubule • Drain urine from nephron to renal pelvis • Lie on medullary ray within cortex • Progressively increase in diameter towards medullar • In inner medullar, CD from different renal lobes unite to form large papillary ducts, which open into renal pelvis
  • 14. • Drain urine from nephron to r. pelvis • Progressively increase in diameter towards medullar • In inner medullar, unite with other CDs to form large papillary ducts, which open into renal pelvis • CD are lined by epithelium that has 2 cell types 1. collecting duct cells – cuboidal in cortical part, columnar in medullary 2. intercalated /dark cells- resemble those of DCT but bulge into lumen of the CD • Both cell types rest on a thin BM and lack basal infoldings • Permeability of CD to water and ions is regulated by ADH
  • 15. URETER • Conducts urine from kidney to bladder • Has 3 tissue layers 1. Tunica mucosa; lined by 5- 6 cell layer of transitional epith that rests on lamina propria of loose c. tissue having bld vessels, lymphatics and with tubular mucus glands in the equidae 2. T. muscularis; has inner and outer longitudinal and middle layer of smooth muscles 3. T. serosa/ adventitia
  • 16. Urinary bladder • Its wall has 4 tissue layers;- 1. Tunica mucosa; lined by up to 14 cell layers of transitional epith that rests on lamina propria of loose c. tissue 2. T. submucosa; highly vascular and rich in elastic fibers 3. T. muscularis; has inner and outer longitudinal and middle layer of smooth muscles (dextruser muscles) 4. T. serosa/ adventitia • The longi muscles form sphincters at ureterovesicular junction to prevent backflow of urine and at neck of bladder to regulate urine emptying
  • 17. Urethra • Its wall has 4 tissue layers 1. Tunica mucosa; epith transitional but changes to stratified squamous at external urethral orifice 2. T. submucosa; has cavernous tissue spaces that are typical of erectile tissue 3. T. muscularis; has inner and outer longi and middle layer of smooth muscles as in bladder but towards external urethral orifice, it acquires an external layer of skeletal muscle called striated urethralis muscle 4. T. serosa/ adventitia