1. Surgical Management of
Chronic Pancreatitis
Dr Happykumar Kagathara
(M.S., Fellowship in Surgical Gastroenterology and Liver Transplantation)
Department of GI Surgery and Advanced Minimal Access
Surgery
Nidhi Hospital, Ahmedabad
CME – IMA, Morbi: September, 2014
2. • Definition
– One end of spectrum of inflammatory and
fibrosing conditions of the pancreas
– Progressive, permanent loss of exocrine and
endocrine
– Irreversible morphologic changes
– Recurrent acute exacerbation or persistent pain
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3. • Etiology
– Alcohol (70%)
– Idiopathic (Tropical) (20%)
– Hypercalcemia
– Recurrent acute severe pancreatitis
– Hereditary and Genetics____
– Obstructive causes_____
• Incidence
– Indian scenario
• 115-200 / 1,00,000 people
• Idiopathic – Most common
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5. • Symptomatology
– Abdominal pain (90%)
• Episodic
• Exacerbated by eating
• “Burnout” period in late phase
– Weight loss
• Avoidance of meals because of exacerbation of pain
• Malabsorption
– Exocrine insufficieny (4-30%)
• Steatorrhoea
• Malabsorption www.nidhihospital.org
6. – Endocrine insufficiency
• 90% parenchyma replaced by fibrosis
– Extrapancreatic complications
• Biliary obstruction (3-30%), due to fibrosis of head of
pancreas
• Duodenal obstruction (2-12%)
• Splenic vein thrombosis (2%)
– Risk of pancreatic cancer
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8. • Indication for surgery
– Intractable abdominal pain
– Secondary complications of chronic pancreatitis
(biliary stricture, duodenal stenosis, pseudocyst,
and suspected pancreatic neoplasm)
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9. • Objectives of surgical management
– Pain relief
– Control of complications
– Preservation of exocrine and endocrine functions
– Social and occupational rehabilitation
– Improvement of quality of life www.nidhihospital.org
10. • Role of surgery in management of pain
– 75-90% success in pain relief
– Pain relief with surgery vs medical treatment
• 63 vs 43% @10 yr
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11. – Timing of surgery
• Non-surgical management as long as possible to avoid
surgical complications
• Better pain relief with early surgical drainage
• Decision regarding timing of surgery be individualized
on a patient to patient basis.
• With failure of medical management, counsel regarding
the risks and benefits of both modalities.
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13. • Hybrid procedures (LR+LPJ)
– Indications
• Dilated duct disease + Inflammation in head of pancres
– Complete pain relief in 92%
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14. • Frey procedure (1987)
– Duodenum-sparing resection of the pancreatic head + No
division of the neck of the pancreas + Longitudinal P-J
of the dorsal duct
– Long-term pain relief and decrease opiate dependence
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15. • Technical variations in Frey procedure
– Izbicki procedure (1998)
» Known as “Hamburg modification”
» Inflammatory head mass + Small duct disease
» More extensive excavation of head + lateral
decompressive pancreaticojejunostomy of the body and
tail
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16. • Drainage procedures
– Indication
• Isolated dilatation of the pancreatic duct >7mm or
“chain of lakes” appearance without an inflammatory
mass in the head
• Generalized parenchymal involvement (no focal
involvement)
• Recurrent or progressive segmental stenosis of the
pancreatic duct
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17. – Procedures
• Duval’s procedure (1954)
– Drainage of the tail with a Roux-en-Y limb of jejunum
– Not effective for disease in the proximal pancreas
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18. • Puestow’s procedure (Lateral P-J) (1958)
– Longitudinal decompression of the body and tail of the
pancreas into a Roux limb of jejunum
– Initially described in conjunction with splenectomy and
the distal pancreatectomy
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19. • Partington’s lateral P-J (1960)
– P-J without resection of the pancreatic tail
– Maximum pancreatic tissue preservation
– Recurrence of symptoms on long term due to incomplete
decompression of MPD in head
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21. • Resection procedures
– Indications
• Focal disease, confined to head of pancreas (except in
distal pancreatectomy)
• Suspicious malignant lesion
• Obstructive complication developed by fibrosis
• Non dilated duct
– Disadvantages
• Endocrine insufficiency
• Exocrine insufficiency
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22. – Procedures
• Whipples PD
– Resection of the head of the pancreas+distal CBD+distal
stomach+duodenum +proximal jejunum
– Also treat bile duct stricture and duodenal obstruction
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23. • Traverso’s pylorus preserving
pancreaticoduodenectomy
– Preservation of pylorus
– Improved QOL compare to Whipples’
pancreaticoduodenectomy
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24. • Distal pancreatectomy
– Isolated involvement of body and tail
– With or without splenectomy
– Stump closure by sutures or stapler application or by
creating a Roux-en-Y pancreatojejunostomy
– Post-operative outcome is similar in both groups
– Drainage procedure should be reserved for patients with
a dilated duct and/or a stricture in the pancreatic
head
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25. – Major portion of parenchyma remains untreated
– High risk of recurrence
– Requirement of completion pancreatectomy in 13%
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26. • Total pancreatectomy
– For persistence or recurrent pain
– Extended hospitalisation due to poor diabetes control
– Profound metabolic consequences in absence of islet
transplantation
– Outcomes identicles with Whipple’s
pancreaticoduodenectomy
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27. • Beger’s duodenum preserving pancreatic head resection
– Division of the neck overlying the confluence of the
splenic and superior mesenteric veins + Removal of the
head of the pancreas, leaving a small rim of pancreatic
tissue along the duodenum
– Maintain GI and biliary continuity
– Better long term outcomes
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28. • Bern Modification of DPPHR
– Pancreas is not divided at level of portal vein
– Useful in significant inflammation and PHTN
– Less intra-operative bleeding
– Equal outcome compare to Beger’s procedure
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29. • Comparison of results (PD vs Beger’s vs Frey)
– Study of 43 patients by Klempa et al
• DPPHR patients had a shorter hospital stay, greater
weight gain, less post operative diabetes, and exocrine
dysfunction than standard Whipple patients
• Pain control was similar between two groups
Klempa I, Spatny M, Menzel J, et al. Chirurg.1995;66:350 –359
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30. – Study of 40 patients by Buchler et al
• DPPHR patients had better pain relief, glucose
tolerance, and weight gain compared with PPPD
patients
Buchler MW, Friess H, Muller MW, et al. Am J Surg. 1995;169:65– 69; discussion 69 –70
– LR-LPJ and DPPHR compared with the PPPD
• Shorter operation times
• Less intraoperative blood loss
• Less perioperative transfusion requirements
Aspelund G, Topazian MD, Lee JH, et al.J Gastrointest Surg. 2005;9: 400 – 409
Koninger J, Seiler CM, Sauerland S, et al. Surgery. 2008;143:490 – 498.
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31. – Study by Farkas et al examined 40 patients
• Randomized to PPPD or organ-preserving pancreatic
head resection (OPPHR)
• OPPHR was associated with a shorter operating time,
less post operative morbidity, shorter hospital stay, and
better quality of life than PPPD.
• The degree of pain relief was equal
Farkas G, Leindler L, Daroczi M, et al. Langenbecks Arch Surg. 2006;391:338 –342
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34. • Conclusion
– Pain relief and quality of life - main concern in
treatment of chronic pancreatitis
– Surgery is indicated for relief of intractable pain
and complications associated with CP
– Timing of surgery should be individualized on a
patient to patient basis.
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35. – Surgical options
• Resection, Decompression procedures, Hybrid
procedures
– DPPHR and LR+LPJ are superior to resection in
term of
• Post-operative outcome,
• Quality of life
• Pain control,
• Glucose tolerance
• Weight gain
• Shorter OT time
• Less blood loss
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36. – Bern’s DPPHR is technically simpler, as reflected
by a significantly shorter operative time and a
significantly shorter hospital stay
– It has broader acceptance in the future because of
technical and economic advantages.
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