1. Genomic Anatomy of the Hippocampus Carol Thompson 1 , Sayan Pathak 1 , Andreas Jeromin 1 , Lydia Ng 1 , Cameron MacPherson 2 , Marty Mortrud,1 Allison Cusick,1 Zackery Riley 1 , Susan Sunkin 1 , Amy Bernard 1 , Ralph Puchalski 1 , Fred Gage 3 , Allan Jones 1 , Vladimir Bajic 2 , Michael Hawrylycz, 1 and Ed Lein 1 1 Allen Institute for Brain Science, Seattle, WA 98103, USA 2 South African National Bioinformatics Institute, University of the Western Cape, Bellville 7535, Cape Town, South Africa 3 Salk Institute for Biological Studies, La Jolla, CA 92037, USA
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4. What is the Hippocampus? Temporal lobe Hippocampus
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10. A Conceptual Model: EC DG CA3 CA1 ParaHp- Sensory components of “where” Perirhinal-Sensory components of object identity = “what” Other sensory inputs
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12. How do we study it? Histology – slice up the brain into fine slices and examine them under the microscope Nissl Stains of the hippocampus
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15. Allen Brain Atlas (ABA) List of In Situ Hybridization data for entire genome!
17. Nonnegative Matrix Factorization x This is a way to break down huge data sets into workable amounts that you can then compare against each other. 98 59 112 73 34 91 64 33 78 7 8 9 6 7 2 5 6 3 8 0 9 3 4 5 2 3 1