ACETATE PATHWAY, Acetate Mevalonate pathway/ Isoprenoid pathway : Formation of terpenes & steroids. Acetate Melonante Pathway: Formation of Fatty acids and Polyketides,

1. Vth Semesester B. pharmacy
Pharmacognosy and Phytochemistry-II
Unit-I
Basic Metabolic Pathway(Part-3)
(Acetate Pathway)
Presented By :
Miss. Pooja D. Bhandare
(Assistant Professor)
Kandhar College of Pharmacy, Nanded

2. ACETATE PATHWAY
It is also one of the important pathway for the synthesis of different
types of secondary metabolites cells of plant.
Why it is know as acetate pathway?: As starting material utilizes in
this pathway is acetate.
This Acetate is utilize in the form of Acetyl Co-A. As t is the active
form of acetate.

3. Acetate occupy central position in relation to general
metabolism, From this only different metabolic pathway
originated for the biosynthesis of different secondary
metabolites.
Different straight chain compounds and aromatic compounds
get biosynthesized from this acetate by different metabolic
pathway.

4. Acetate pathway have two main route : that means there is
mainly 2 main pathway in which this acetate is utilized a
starting material.
1. Acetate Mevalonate pathway/ Isoprenoid pathway :
Formation of terpenes & steroids.
2. Acetate Melonante Pathway: Formation of Fatty acids
and Polyketides

5. Glycolysis
Pyruvate
Acetyl CoA
Acetate Mevalonate
Pathway
Acetate Melonate
Pathway
Mevalonic acid
Malonyl CoA

6. ACETATE MEVOLNATE PATHWAY/ MEVALONIC ACID
PATHWAY/ISOPRENOIDS PATHWAY/ METHYLERYTHRITOL
PATHWAY
Contribute 1/3rd know secondary metabolite
One of the most important intermediate formed or utilized in this pathway is
Mevalonate that is mevalonic acid.
This mevalonate or mevalonic acid i.e intermediate which synthesize in this
pathway, this mevalonate only further used for the synthesis of terpenoids.
Terpenoids are derived from isoprene units which are joined in head-to-tail or
head-to head .

8.  The mevalonate pathway are used by nature to prepare Dimethylallyl Pyrophosphate(DMAPP)
and Isopentenyl Pyrophosphate(IPP).

11. ACETATE MELONANTE PATHWAY
Polyketide constituent a large class of natural products grouped together
on purely biosynthetic pathways.
Their diverse structures can be explained as being derived from poly-β-
keto chains formed by coupling of acetic acid (C2) units via condensation
reactions.
Included in such compounds are fatty acids, polyacetylenes,
prostaglandins, macrolide antibiotics and many aromatic compounds, e.g.,
anthraquinones and tetracyclines.

12. THANK YOU!